Factor analysis of responses from 1002 men and women were used to define two subscales of the Cook and Medley Hostility Scale. Both the Cynicism and the Paranoid Alienation subscale described attitudes of mistrust and alienation, and both were correlated with MMPI factors measuring aspects of psychopathology. It was suggested that measures of the broader domain of Agreeableness-Antagonism be examined as possible predictors of CHD. To examine the contention that well-being scales are contaminated by socially desirable responding, three well-being measures were correlated with peer ratings of neuroticism before and after controlling for Edwards' social desirability in a sample of 62 adult men and women. Because social desirability was correlated with rated neuroticism, correcting for social desirability bias decreased, rather than increased, the validity of well-being measures as judged against an external criterion. Findings support the position that self- reports of well-being can generally be taken as veridical assessments.