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Laboratory of Neurosciences Investigators
2005 Publications

  1. Ahmet I, Wan R, Mattson MP, Lakatta EG, Talan M. Cardioprotection by intermittent fasting in rats. Circulation. 2005;112(20):3115-3121. [Abs]

  2. Arumugam TV, Granger DN, Mattson MP. Stroke and T-cells. Neuromolecular Med. 2005;7(3):229-242. [Abs]

  3. Ballard CG, Greig NH, Guillozet-Bongaarts AL, Enz A, Darvesh S. Cholinesterases: roles in the brain during health and disease. Curr Alzheimer Res. 2005;2(3):307-318. [Abs]

  4. Camandola S, Cutler RG, Gary DS, Milhavet O, Mattson MP. Suppression of calcium release from inositol 1,4,5-trisphosphate-sensitive stores mediates the anti-apoptotic function of nuclear factor-kB. J Biol Chem. 2005;280(23):22287-22296. [Abs]

  5. Campiani G, Fattorusso C, Butini S, Gaeta A, Agnusdei M, Gemma S, Persico M, Catalanotti B, Savini L, Nacci V, Novellino E, Holloway HW, Greig NH, Belinskaya T, Fedorko JM, Saxena A. Development of molecular probes for the identification of extra interaction sites in the mid-gorge and peripheral sites of butyrylcholinesterase (BuChE). Rational design of novel, selective, and highly potent BuChE inhibitors. J Med Chem. 2005;48(6):1919-1929. [Abs]

  6. Carmona GN, Schindler CW, Greig NH, Holloway HW, Jufer RA, Cone EJ, Gorelick DA. Intravenous butyrylcholinesterase administration and plasma and brain levels of cocaine and metabolites in rats. Eur J Pharmacol. 2005;517(3):186-190.

  7. Cerasoli DM, Griffiths EM, Doctor BP, Saxena A, Fedorko JM, Greig NH, Yu QS, Huang Y, Wilgus H, Karatzas CN, Koplovitz I, Lenz DE. In vitro and in vivo characterization of recombinant human butyrylcholinesterase (Protexia) as a potential nerve agent bioscavenger. Chem Biol Interact. 2005;157-158:363-365.

  8. Culmsee C, Mattson MP. p53 in neuronal apoptosis. Biochem Biophys Res Commun. 2005;331(3):761-777.

  9. Doyle ME, McConville P, Theodorakis MJ, Goetschkes MM, Bernier M, Spencer RG, Holloway HW, Greig NH, Egan JM. In vivo biological activity of exendin (1-30). Endocrine. 2005;27(1):1-9. [Abs]

  10. Engelstein R, Grigoriadis N, Greig NH, Ovadia H, Gabizon R. Inhibition of P53-related apoptosis had no effect on PrP(Sc) accumulation and prion disease incubation time. Neurobiol Dis. 2005;18(2):282-285. [Abs]

  11. Greig NH, Lahiri DK, Giacobini E. Editorial: advances in Alzheimer therapy: something old, something new, something borrowed, something blue. Curr Alzheimer Res. 2005;2(3):275-279.

  12. Greig NH, Ruckle J, Comer P, Brownell L, Holloway HW, Flanagan DR Jr, Canfield CJ, Burford RG. Anticholinesterase and pharmacokinetic profile of phenserine in healthy elderly human subjects. Curr Alzheimer Res. 2005;2(4):483-492. [Abs]

  13. Greig NH, Sambamurti K, Yu QS, Brossi A, Bruinsma GB, Lahiri DK. An overview of phenserine tartrate, a novel acetylcholinesterase inhibitor for the treatment of Alzheimer's disease. Curr Alzheimer Res. 2005;2(3):281-290. [Abs]

  14. Greig NH, Utsuki T, Ingram DK, Wang Y, Pepeu G, Scali C, Yu QS, Mamczarz J, Holloway HW, Giordano T, Chen D, Furukawa K, Sambamurti K, Brossi A, Lahiri DK. Selective butyrylcholinesterase inhibition elevates brain acetylcholine, augments learning and lowers Alzheimer b-amyloid peptide in rodent. Proc Natl Acad Sci USA. 2005;102(47):17213-17218. [Abs]

  15. Guiotto A, Calderan A, Ruzza P, Osler A, Rubini C, Jo DG, Mattson MP, Borin G. Synthesis and evaluation of neuroprotective a,b-unsaturated aldehyde scavenger histidyl-containing analogues of carnosine. J Med Chem. 2005;48(19):6156-6161. [Abs]

  16. Hasegawa T, Ukai W, Jo DG, Xu X, Mattson MP, Nakagawa M, Araki W, Saito T, Yamada T. Homocysteic acid induces intraneuronal accumulation of neurotoxic Ab42: implications for the pathogenesis of Alzheimer's disease. J Neurosci Res. 2005;80(6):869-876. [Abs]

  17. Iser WB, Kim D, Bachman E, Wolkow C. Examination of the requirement for ucp-4, a putative homolog of mammalian uncoupling proteins, for stress tolerance and longevity in C. elegans. Mech Ageing Dev. 2005;126(10):1090-1096.

  18. Janas AM, Cunningham SC, Duffy KB, Devan BD, Greig NH, Holloway HW, Yu QS, Markowska AL, Ingram DK, Spangler EL. The cholinesterase inhibitor, phenserine, improves Morris water maze performance of scopolamine-treated rats. Life Sci. 2005;76(10):1073-1081. [Abs]

  19. Kruman II, Mouton PR, Emokpae R Jr, Cutler RG, Mattson MP. Folate deficiency inhibits proliferation of adult hippocampal progenitors. Neuroreport. 2005;16(10):1055-1059. [Abs]

  20. Lahiri DK, Chen DM, Lahiri P, Bondy S, Greig NH. Amyloid, cholinesterase, melatonin, and metals and their roles in aging and neurodegenerative diseases. Ann NY Acad Sci. 2005;1056:430-449. [Abs]

  21. Li W, Galey D, Mattson MP, Nath A. Molecular and cellular mechanisms of neuronal cell death in HIV dementia. Neurotox Res. 2005;8(1-2):119-134. [Abs]

  22. Liu D, Wu L, Breyer R, Mattson MP, Andreasson K. Neuroprotection by the PGE2 EP2 receptor in permanent focal cerebral ischemia. Ann Neurol. 2005;57(5):758-761. [Abs]

  23. Luo W, Yu QS, Holloway HW, Parrish D, Greig NH, Brossi A. Syntheses of tetrahydrofurobenzofurans and dihydromethanobenzodioxepines from 5-hydroxy-3-methyl-3H-benzofuran-2-one. Rearrangement and ring expansion under reductive conditions on treatment with hydrides. J Org Chem. 2005;70(16):6171-6176. [Abs]

  24. Luo W, Yu QS, Zhan M, Parrish D, Deschamps JR, Kulkarni SS, Holloway HW, Alley GM, Lahiri DK, Brossi A, Greig NH. Novel anticholinesterases based on the molecular skeletons of furobenzofuran and methanobenzodioxepine. J Med Chem. 2005;48(4):986-994. [Abs]

  25. Martin B, de Maturana RL, Brenneman R, Walent T, Mattson MP, Maudsley S. Class II G protein-coupled receptors and their ligands in neuronal function and protection. Neuromolecular Med. 2005;7(1-2):3-36.

  26. Mattson MP. Energy intake, meal frequency, and health: a neurobiological perspective. Annu Rev Nutr. 2005;25:237-260. [Abs]

  27. Mattson MP. Human fetal brain cell culture. Methods Mol Med. 2005;107:163-171.

  28. Mattson MP. NF-kB in the survival and plasticity of neurons. Neurochem Res. 2005;30(6-7):883-893.

  29. Mattson MP. The need for controlled studies of the effects of meal frequency on health. Lancet. 2005;365(9475):1978-1980.

  30. Mattson MP, Cutler RG, Jo DG. Alzheimer peptides perturb lipid-regulating enzymes. Nat Cell Biol. 2005;7(11):1045-1047.

  31. Mattson MP, Gleichmann M. The neuronal death protein par-4 mediates dopaminergic synaptic plasticity. Mol Interv. 2005;5(5):278-281. [Abs]

  32. Mattson MP, Haughey NJ, Nath A. Cell death in HIV dementia. Cell Death Differ. 2005;12(Suppl 1):22287-22296.

  33. Mattson MP, Wan R. Beneficial effects of intermittent fasting and caloric restriction on the cardiovascular and cerebrovascular systems. J Nutr Biochem. 2005;16(3):129-137.

  34. McCampbell A, Truong D, Broom DC, Allchorne A, Gable K, Cutler RG, Mattson MP, Woolf CJ, Frosch MP, Harmon JM, Dunn TM, Brown RH Jr. Mutant SPTLC1 dominantly inhibits serine palmitoyltransferase activity in vivo and confers an age-dependent neuropathy. Hum Mol Genet. 2005;14(22):3507-3521. [Abs]

  35. Perry T, Greig NH. Enhancing central nervous system endogenous GLP-1 receptor pathways for intervention in Alzheimer's disease. Curr Alzheimer Res. 2005;2(3):377-385. [Abs]

  36. Petkova AT, Leapman RD, Guo Z, Yau WM, Mattson MP, Tycko R. Self-propagating, molecular-level polymorphism in Alzheimer's b-amyloid fibrils. Science. 2005;307(5707):262-265. [Abs]

  37. Sun X, Beglopoulos V, Mattson MP, Shen J. Hippocampal spatial memory impairments caused by the familial Alzheimer's disease-linked presenilin 1 M146V mutation. Neurodegener Dis. 2005;2(1):6-15.

2004 Publications

  1. Bhattacharya B, Miura T, Brandenberger R, Mejido J, Luo Y, Yang AX, Joshi BH, Ginis I, Thies RS, Amit M, Lyons I, Condie BG, Itskovitz-Eldor J, Rao MS, Puri RK. Gene expression in human embryonic stem cell lines: unique molecular signature. Blood. 2004;103(8):2956-2964. [Abs]

  2. Brandenberger R, Khrebtukova I, Thies RS, Miura T, Jingli C, Puri R, Vasicek T, Lebkowski J, Rao M. MPSS profiling of human embryonic stem cells. BMC Dev Biol. 2004;4(1):10. [Abs]

  3. Brandenberger R, Wei H, Zhang S, Lei S, Murage J, Fisk GJ, Li Y, Xu C, Fang R, Guegler K, Rao MS, Mandalam R, Lebkowski J, Stanton LW. Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. Nat Biotechnol. 2004;22(6):707-716. [Abs]

  4. Brazel CY, Rao MS. Aging and neuronal replacement. Ageing Res Rev. 2004;3(4):465-483. [Abs]

  5. Cai J, Cheng A, Luo Y, Lu C, Mattson MP, Rao MS, Furukawa K. Membrane properties of rat embryonic multipotent neural stem cells. J Neurochem. 2004;88(1):212-226. [Abs]

  6. Cai J, Weiss ML, Rao MS. In search of "stemness". Exp Hematol. 2004;32(7):585-598. [Abs]

  7. Carpenter MK, Rosler ES, Fisk GJ, Brandenberger R, Ares X, Miura T, Lucero M, Rao MS. Properties of four human embryonic stem cell lines maintained in a feeder-free culture system. Dev Dyn. 2004;229(2):243-258. [Abs]

  8. Chalimoniuk M, King-Pospisil K, Pedersen WA, Malecki A, Wylegala E, Mattson MP, Hennig B, Toborek M. Arachidonic acid increases choline acetyltransferase activity in spinal cord neurons through a protein kinase C-mediated mechanism. J Neurochem. 2004;90(3):629-636. [Abs]

  9. Chan SL, Fu W, Zhang P, Cheng A, Lee J, Kokame K, Mattson MP. Herp stabilizes neuronal Ca2+ homeostasis and mitochondrial function during endoplasmic reticulum stress. J Biol Chem. 2004;279(27):28733-28743. [Abs]

  10. Cheng A, Tang H, Cai J, Zhu M, Zhang X, Rao M, Mattson MP. Gap junctional communication is required to maintain mouse cortical neural progenitor cells in a proliferative state. Dev Biol. 2004;272(1):203-216. [Abs]

  11. Cutler RG, Haughey NJ, Tammara A, McArthur JC, Nath A, Reid R, Vargas DL, Pardo CA, Mattson MP. Dysregulation of sphingolipid and sterol metabolism by ApoE4 in HIV dementia. Neurology. 2004;63(4):626-630. [Abs]

  12. Cutler RG, Kelly J, Storie K, Pedersen WA, Tammara A, Hatanpaa K, Troncoso JC, Mattson MP. Involvement of oxidative stress-induced abnormalities in ceramide and cholesterol metabolism in brain aging and Alzheimer's disease. Proc Natl Acad Sci USA. 2004;101(7):2070-2075. [Abs]

  13. Duan W, Guo Z, Jiang H, Ladenheim B, Xu X, Cadet JL, Mattson MP. Paroxetine retards disease onset and progression in Huntingtin mutant mice. Ann Neurol. 2004;55(4):590-594. [Abs]

  14. Getchell TV, Peng X, Green CP, Stromberg AJ, Chen KC, Mattson MP, Getchell ML. In silico analysis of gene expression profiles in the olfactory mucosae of aging senescence-accelerated mice. J Neurosci Res. 2004;77(3):430-452. [Abs]

  15. Ginis I, Luo Y, Miura T, Thies S, Brandenberger R, Gerecht-Nir S, Amit M, Hoke A, Carpenter MK, Itskovitz-Eldor J, Rao MS. Differences between human and mouse embryonic stem cells. Dev Biol. 2004;269(2):360-380. [Abs]

  16. Glenn CF, Chow DK, David L, Cooke CA, Gami MS, Iser WB, Hanselman KB, Goldberg IG, Wolkow CA. Behavioral deficits during early stages of aging in Caenorhabditis elegans result from locomotory deficits possibly linked to muscle frailty. J Gerontol A Biol Sci Med Sci. 2004;59(12):1251-1260. [Abs]

  17. Greig NH, Giordano T, Zhu X, Yu QS, Perry TA, Holloway HW, Brossi A, Rogers JT, Sambamurti K, Lahiri DK. Thalidomide-based TNF-a inhibitors for neurodegenerative diseases. Acta Neurobiol Exp (Wars). 2004;64(1):1-9. [Abs]

  18. Greig NH, Mattson MP, Perry T, Chan SL, Giordano T, Sambamurti K, Rogers JT, Ovadia H, Lahiri DK. New therapeutic strategies and drug candidates for neurodegenerative diseases: p53 and TNF-a inhibitors, and GLP-1 receptor agonists. Ann NY Acad Sci. 2004;1035:290-315. [Abs]

  19. Guo Z, Iyun T, Fu W, Zhang P, Mattson MP. Bone marrow transplantation reveals roles for brain macrophage/microglia TNF signaling and nitric oxide production in excitotoxic neuronal death. Neuromolecular Med. 2004;5(3):219-234. [Abs]

  20. Han SS, Liu Y, Tyler-Polsz C, Rao MS, Fischer I. Transplantation of glial-restricted precursor cells into the adult spinal cord: survival, glial-specific differentiation, and preferential migration in white matter. Glia. 2004;45(1):1-16. [Abs]

  21. Haughey NJ, Cutler RG, Tamara A, McArthur JC, Vargas DL, Pardo CA, Turchan J, Nath A, Mattson MP. Perturbation of sphingolipid metabolism and ceramide production in HIV-dementia. Ann Neurol. 2004;55(2):257-267. [Abs]

  22. Kruman II, Schwartz E, Kruman Y, Cutler RG, Zhu X, Greig NH, Mattson MP. Suppression of uracil-DNA glycosylase induces neuronal apoptosis. J Biol Chem. 2004;279(42):43952-439560. [Abs]

  23. Kruman II, Wersto RP, Cardozo-Pelaez F, Smilenov L, Chan SL, Chrest FJ, Emokpae R Jr, Gorospe M, Mattson MP. Cell cycle activation linked to neuronal cell death initiated by DNA damage. Neuron. 2004;41(4):549-561. [Abs]

  24. Lahiri DK, Chen D, Lahiri P, Rogers JT, Greig NH, Bondy S. Melatonin, metals, and gene expression: implications in aging and neurodegenerative disorders. Ann NY Acad Sci. 2004;1035:216-230. [Abs]

  25. Lahiri DK, Greig NH. Lethal weapon: amyloid b-peptide, role in the oxidative stress and neurodegeneration of Alzheimer's disease. Neurobiol Aging. 2004;25(5):581-587. [Abs]

  26. Lahiri DK, Rogers JT, Greig NH, Sambamurti K. Rationale for the development of cholinesterase inhibitors as anti-Alzheimer agents. Curr Pharm Des. 2004;10(25):3111-3119. [Abs]

  27. Lane RM, Kivipelto M, Greig NH. Acetylcholinesterase and its inhibition in Alzheimer Disease. Clin Neuropharmacol. 2004;27(3):141-149. [Abs]

  28. Leker RR, Aharonowiz M, Greig NH, Ovadia H. The role of p53-induced apoptosis in cerebral ischemia: effects of the p53 inhibitor pifithrin a. Exp Neurol. 2004;187(2):478-486. [Abs]

  29. Levenson CW, Cutler RG, Ladenheim B, Cadet JL, Hare J, Mattson MP. Role of dietary iron restriction in a mouse model of Parkinson's disease. Exp Neurol. 2004;190(2):506-514. [Abs]

  30. Liu Y, Rao MS. Glial progenitors in the CNS and possible lineage relationships among them. Biol Cell. 2004;96(4):279-290. [Abs]

  31. Liu Y, Rao MS. Olig genes are expressed in a heterogeneous population of precursor cells in the developing spinal cord. Glia. 2004;45(1):67-74. [Abs]

  32. Maragakis NJ, Dietrich J, Wong V, Xue H, Mayer-Proschel M, Rao MS, Rothstein JD. Glutamate transporter expression and function in human glial progenitors. Glia. 2004;45(2):133-143. [Abs]

  33. Maswood N, Young J, Tilmont E, Zhang Z, Gash DM, Gerhardt GA, Grondin R, Roth GS, Mattison J, Lane MA, Carson RE, Cohen RM, Mouton PR, Quigley C, Mattson MP, Ingram DK. Caloric restriction increases neurotrophic factor levels and attenuates neurochemical and behavioral deficits in a primate model of Parkinson's disease. Proc Natl Acad Sci USA. 2004;101(52):18171-18176. [Abs]

  34. Matsuzaki M, Hasegawa T, Takeda A, Kikuchi A, Furukawa K, Kato Y, Itoyama Y. Histochemical features of stress-induced aggregates in a-synuclein overexpressing cells. Brain Res. 2004;1004(1-2):83-90. [Abs]

  35. Mattson MP. Human fetal brain cell culture. Methods Mol Med. 2004;107:163-172. [Abs]

  36. Mattson MP. Infectious agents and age-related neurodegenerative disorders. Ageing Res Revs. 2004;3:105-120. [Abs]

  37. Mattson MP. Metal-catalyzed disruption of membrane protein and lipid signaling in the pathogenesis of neurodegenerative disorders. Ann NY Acad Sci. 2004;1012:37-50. [Abs]

  38. Mattson MP. Pathways towards and away from Alzheimer's disease. Nature. 2004;430(7000):631-639. [Abs]

  39. Mattson MP, Duan W, Wan R, Guo Z. Prophylactic activation of neuroprotective stress response pathways by dietary and behavioral manipulations. NeuroRx. 2004;1(1):111-116.

  40. Mattson MP, Maudsley S, Martin B. A neural signaling triumvirate that influences ageing and age-related disease: insulin/IGF-1, BDNF and serotonin. Ageing Res Rev. 2004;3(4):445-464. [Abs]

  41. Mattson MP, Maudsley S, Martin B. BDNF and 5-HT: a dynamic duo in age-related neuronal plasticity and neurodegenerative disorders. Trends Neurosci. 2004;27(10):589-594. [Abs]

  42. Mattson MP, Taub DD. Ancient viral protein enrages astrocytes in multiple sclerosis. Nat Neurosci. 2004;7(10):1021-1023. [Abs]

  43. Miura T, Mattson MP, Rao MS. Cellular lifespan and senescence signaling in embryonic stem cells. Aging Cell. 2004;3(6):333-343. [Abs]

  44. Perry TA, Greig NH. A new Alzheimer's disease interventive strategy: GLP-1. Curr Drug Targets. 2004;5(6):565-571. [Abs]

  45. Perry TA, Weerasuriya A, Mouton PR, Holloway HW, Greig NH. Pyridoxine-induced toxicity in rats: a stereological quantification of the sensory neuropathy. Exp Neurol. 2004;190(1):133-144. [Abs]

  46. Rao M. Conserved and divergent paths that regulate self-renewal in mouse and human embryonic stem cells. Dev Biol. 2004;275(2):269-286. [Abs]

  47. Rao M. Stem and precursor cells in the nervous system. J Neurotrauma. 2004;21(4):415-427. [Abs]

  48. Rao M. Stem sense: a proposal for the classification of stem cells. Stem Cells Dev. 2004;13(5):452-455. [Abs]

  49. Rosler ES, Fisk GJ, Ares X, Irving J, Miura T, Rao MS, Carpenter MK. Long-term culture of human embryonic stem cells in feeder-free conditions. Dev Dyn. 2004;229(2):259-274. [Abs]

  50. Sambamurti K, Granholm AC, Kindy MS, Bhat NR, Greig NH, Lahiri DK, Mintzer JE. Cholesterol and Alzheimer's disease: clinical and experimental models suggest interactions of different genetic, dietary and environmental risk factors. Curr Drug Targets. 2004;5(6):517-528. [Abs]

  51. Stein TD, Anders NJ, DeCarli C, Chan SL, Mattson MP, Johnson JA. Neutralization of transthyretin reverses the neuroprotective effects of secreted amyloid precursor protein (APP) in APPSW mice resulting in tau phosphorylation and loss of hippocampal neurons: support for the amyloid hypothesis. J Neurosci. 2004;24(35):7707-7717. [Abs]

  52. Toescu EC, Verkhratsky A, Mattson MP. Synaptic function and behavior during normal ageing. Ageing Res Rev. 2004;3(4):v. [Abs]

  53. Tuohy TM, Wallingford N, Liu Y, Chan FH, Rizvi T, Xing R, Bebo B, Rao MS, Sherman LS. CD44 overexpression by oligodendrocytes: a novel mouse model of inflammation-independent demyelination and dysmyelination. Glia. 2004;47(4):335-345. [Abs]

  54. Venti A, Giordano T, Eder P, Bush AI, Lahiri DK, Greig NH, Rogers JT. The integrated role of Desferrioxamine and Phenserine targeted to an iron-responsive element in the APP-mRNA 5'-untranslated region. Ann NY Acad Sci. 2004;1035:34-48. [Abs]

  55. Verkhratsky A, Mattson MP, Toescu EC. Aging in the mind. Trends Neurosci. 2004;27(10):577-578. [Abs]

  56. Wan R, Camandola S, Mattson MP. Dietary supplementation with 2-deoxy-D-glucose improves cardiovascular and neuroendocrine stress adaptation in rats. Am J Physiol Heart Circ Physiol. 2004;287(3):H1186-H1193. [Abs]

  57. Wang Y, Chan SL, Miele L, Yao PJ, Mackes J, Ingram DK, Mattson MP, Furukawa K. Involvement of Notch signaling in hippocampal synaptic plasticity. Proc Natl Acad Sci USA. 2004;101(25):9458-9462. [Abs]

  58. Wang Y, Haughey NJ, Mattson MP, Furukawa K. Dual effects of ATP on rat hippocampal synaptic plasticity. Neuroreport. 2004;15(4):633-636. [Abs]

  59. Zeng X, Cai J, Chen J, Luo Y, You ZB, Fotter E, Wang Y, Harvey B, Miura T, Backman C, Chen GJ, Rao MS, Freed WJ. Dopaminergic differentiation of human embryonic stem cells. Stem Cells. 2004;22(6):925-940. [Abs]

  60. Zeng X, Miura T, Luo Y, Bhattacharya B, Condie B, Chen J, Ginis I, Lyons I, Mejido J, Puri RK, Rao MS, Freed WJ. Properties of pluripotent human embryonic stem cells BG01 and BG02. Stem Cells. 2004;22(3):292-312. [Abs]

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Updated: Thursday October 11, 2007