| Studies of animal models of neurodegenerative disorders have provided evidence that diet can greatly impact neuronal vulnerability. For example, maintenance of adult rats or mice on a dietary restriction regimen can increase resistance of neurons in the hippocampus to excitotoxic injury, as shown in this seizure model of neuronal loss and memory impairment. The beneficial effect of dietary restriction can be mimicked by dietary supplementation with 2-deoxy-D-glucose, a non-metabolisable glucose analog. |
