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National Institute on Aging
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Intramural

Catherine A. Wolkow, Ph.D. Catherine A. Wolkow, Ph.D., Investigator
Head, Invertebrate Molecular Genetics Unit
Laboratory of Neurosciences

E-mail: wolkowca@mail.nih.gov

Education:

1997 - Ph.D., Genetics and Molecular Biology, Johns Hopkins University School of Medicine, Baltimore, MD

1990- B.A., Chemistry, Pomona College, Claremont, CA

Postdoctoral Training:

1997-2001 - Dept. of Molecular Biology Massachusetts General Hospital and Dept. of Genetics, Harvard University, Boston, MA

Awards:

1998-2001 - Research Fellow, Leukemia and Lymphoma Society of America

Professional Society Memberships:

The Genetics Society of America
American Association for the Advancement of Science

Publications:

  1. Chow DK, Glenn CF, Johnston JL, Goldberg IG, Wolkow CA. (2006) Sarcopenia in the Caenorhabditis elegans pharynx correlates with muscle contraction rate over lifespan. Exp. Gerontol. [epub ahead of print]. [Abs]

  2. Wilson MA, Shukitt-Hale B, Kalt W, Ingram DK, Joseph JA, Wolkow CA. (2006) Blueberry polyphenols increase lifespan and thermotolerance in Caenorhabditis elegans. Aging Cell 5(1): 59-68. [Abs]

  3. Gami MS, Wolkow CA. (2006) Studies of Caenorhabditis elegans DAF-2/insulin signaling reveal targets for pharmacological manipulation of lifespan. Aging Cell 5(1): 31-37. [Abs]

  4. Glenn CF, Chow DK, David L, Cooke CA, Gami MS, Iser WB, Hanselman KB, Goldberg IG, Wolkow CA. (2004) Behavioral deficits during early stages of aging in Caenorhabditis elegans result from locomotory deficits possibly linked to muscle frailty. J. Gerontol. A Biol. Sci. Med. Sci. 59(12): 1251-1260. [Abs]

  5. Wolkow CA, Munoz MJ, Riddle DL, Ruvkun G. (2002) "Insulin receptor substrate and p55 orthologous adaptor proteins function in the Caenorhabditis elegans daf-2/insulin-like signaling pathway. J. Biol. Chem. 277: 49591-49597. [Abs] - [Full Text]

  6. Wolkow CA. (2002) "Life span: Getting the signal from the nervous system." Trends in Neuroscience. 25: 212-216. [Abs]

  7. Wolkow CA, Kimura KD, Lee M-S, Ruvkun G. (2000) "Regulation of C. elegans lifespan by insulin-like signaling in the nervous system." Science. 290: 147-150. [Abs]

  8. Wolkow CA, Ruvkun G. "Adaptor proteins potentiate signaling by the C. elegans daf-2/insulin-like pathway." In preparation.

  9. Wolkow CA, DeBoy RT, Craig NL. (1996) "Conjugating plasmids are preferred targets for Tn7." Genes Dev. 10: 2145-2157. [Abs]

  10. Roher A.E., Lowenson JD, Clarke S, Wolkow C, Wang R, Cotter RJ, Reardon IM, Zurcher-Neely HA, Heinrikson RL, Ball MJ, Greenberg BD. (1993) "Structural alterations in the peptide backbone of beta-amyloid core protein may account for its deposition and stability in AlzheimerÝs disease." J. Biol. Chem. 268: 3072-83.

  11. Keefe LJ, Lattman EE, Wolkow C, Woods A, Chevrier M, Cotter RJ. (1992) "Resolution of a protein sequence ambiguity by X-ray crystallographic and mass spectrometric methods." J. Appl. Cryst. 25: 205-210.

  12. Kastan MB, Radin AI, Kuerbitz SJ, Onyekwere O, Wolkow CA, Civin CI, Stone KD, Woo T, Ravindranath Y, Craig RW. (1991) "Levels of p53 protein increase with maturation in human hematopoietic cells." Cancer Res. 51, 4279-4286. [Abs]

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