| Laboratory of Molecular Biology and Immunology |
| Ranjan Sen, Ph.D., Chief Senior Investigator |
| Overview |
| The goal of the Laboratory of Molecular Biology and Immunology (LMBI) is to elucidate the molecular mechanisms of processes that contribute to age-associated changes in physiology, including diseases whose prevalence increases with age. Our research can be viewed in terms of three interconnected themes: 1) Molecular mechanisms of basic cellular processes, 2) Immune cell function, and 3) translating basic mechanisms to clinical research. |
| Major areas of emphasis include: 1) elucidation of signal transduction processes and genes involved in regulating cellular responses to environmental signals such as growth factors, cytokines, and stress stimuli; 2) molecular mechanisms of antibody diversity, 3) mechanisms controlling lymphocyte development, and 4) contribution of dysregulated gene expression to the development of cancer. As described below for the individual programs, a wide variety of in vitro and in vivo models are employed to approach these issues. These processes have direct relevance to our understanding of critical events associated with various age-related deficits and/or development of age-related diseases including cancer. The ultimate goal of the programs is to uncover basic knowledge that can be applied to prevent or delay the onset of age-related disabilities and disease processes, and provide new strategies for treatment. |
| Research Programs |
| The Laboratory of Molecular Biology and Immunology periodically has openings for outstanding post-doctoral fellows. Direct inquiries to: |
| National Institute on Aging Intramural Research Program Laboratory of Molecular Biology and Immunology Biomedical Research Center 251 Bayview Boulevard, Suite 100 Baltimore, MD 21224 Phone: 410-558-8027 Fax: 410-558-8386 |
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