Developmental Genomics and Aging
Section |
Minoru S.H. Ko,
M.D., Ph.D., Chief
Senior Investigator
|
| Overview: The long-term goal is to understand the fundamental mechanisms for the
maintenance of self-renewal, immortality, and pluripotency of early mouse
embryos and stem cells. Studies will utilize the potential of a systematic
genomic approach - embryogenomics - to analyze
global gene expression regulations. We believe that such global studies will
provide greater understanding of mechanisms that will aid in the adaptation
of stem cells to replacement therapy - regenerative medicine - for aging and
dysfunctional cells and organs. |
Projects
- Systematic Analysis
of Gene Regulatory Networks: studying gene regulatory networks
in embryonic stem (ES) cells by systematically manipulating
transcription factors and environmental conditions (NIA mouse ES cell bank). The project is also based on the resources developed by the NIA mouse cDNA project (completed).
- Preimplantation Mouse
Development: studying gene expression regulation in early
embryos (from fertilization to implantation), which are the source of ES
cells and the locus of nuclear reprogramming
- Embryonic and
Tissue Stem Cells:studying molecular similarities and
differences between these stem cells
|
Resources
- Downloads: Scientific data related to our publications, microarray data sets,
sequence data sets and annotations
- Materials: NIA 15K and
7.4K mouse cDNA clone sets, DNA microarrays,
mouse ES cells
- Methods: Laboratory protocols, including the ES cell manipulation and in situ hybridization
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| Software tools and databases >ALL
|
| Members |
| Positions |
Publications >ALL
- Zalzman,Falco et al.
Zscan4 regulates telomere elongation and genomic stability in ES cells. Nature. 2010 Mar 24 [Epub ahead of print]. [Abs]
- Nishiyama, Xin et al.
Uncovering early response of gene regulatory networks in ES cells by
systematic induction of transcription factors. Cell Stem Cell. 2009 Oct 2;5(4):420-33. [Abs]
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