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National Institute on Aging
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Developmental Genomics and Aging Section

Minoru S.H. Ko, M.D., Ph.D., Chief
Senior Investigator

Overview:  The long-term goal is to understand the fundamental mechanisms for the maintenance of self-renewal, immortality, and pluripotency of early mouse embryos and stem cells. Studies will utilize the potential of a systematic genomic approach - embryogenomics - to analyze global gene expression regulations. We believe that such global studies will provide greater understanding of mechanisms that will aid in the adaptation of stem cells to replacement therapy - regenerative medicine - for aging and dysfunctional cells and organs.


  • Systematic Analysis of Gene Regulatory Networks: studying gene regulatory networks in embryonic stem (ES) cells by systematically manipulating transcription factors and environmental conditions (NIA mouse ES cell bank). The project is also based on the resources developed by the NIA mouse cDNA project (completed).
  • Preimplantation Mouse Development: studying gene expression regulation in early embryos (from fertilization to implantation), which are the source of ES cells and the locus of nuclear reprogramming
  • Embryonic and Tissue Stem Cells:studying molecular similarities and differences between these stem cells


  • Downloads: Scientific data related to our publications, microarray data sets, sequence data sets and annotations
  • Materials:      NIA 15K and 7.4K mouse cDNA clone sets, DNA microarrays, mouse ES cells
  • Methods:       Laboratory protocols, including the ES cell manipulation and in situ hybridization
Software tools and databases     >ALL

Publications     >ALL

  • Zalzman,Falco et al. Zscan4 regulates telomere elongation and genomic stability in ES cells. Nature. 2010 Mar 24 [Epub ahead of print]. [Abs]
  • Nishiyama, Xin et al. Uncovering early response of gene regulatory networks in ES cells by systematic induction of transcription factors. Cell Stem Cell. 2009 Oct 2;5(4):420-33. [Abs]
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Updated: Friday July 19, 2013