National Institute on Aging
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Intramural
Laboratory of Experimental Gerontology
Publications

  1. Alexander GE, Chen K, Aschenbrenner M, Merkley TL, Santerre-Lemmon LE, Shamy JL, Skaggs W, Buonocore MH, Rapp PR and Barnes CA: Age-related regional network of MRI gray matter in rhesus macaque, J. Neurosci., accepted pending revision.

  2. Allard, J.S., Heilbronn, L.K., Smith, C., Hunt, N.D., Ingram, D.K., Ravussin, E., Pennington CALERIE Team, de Cabo, R. In vitro cellular adaptations of biomarkers of longevity in response to treatment with serum collected from humans on calorie restricted diets. PLoS ONE. 2008 Accepted.

  3. Branch-Mays GL, Dawson DR, Gunsolley JC, Reynolds MA, Ebersole JL, Novak KF, Mattison JA, Ingram DK, Novak MJ. The effects of a calorie-reduced diet on periodontal inflammation and disease in a non-human primate model. J Periodontol. 2008;79(7):1184-1191.

  4. Csiszar A, Labinskyy N, Podlutsky A, Kaminski PM, Wolin MS, Zhang C, Mukhopadhyay P, Pacher P, Hu F, de Cabo R, Ballabh P, Ungvari Z. Vasoprotective effects of resveratrol and SIRT1: attenuation of cigarette smoke-induced oxidative stress and proinflammatory phenotypic alterations. Am J Physiol Heart Circ Physiol. 2008;294(6):H2721-H2735.

  5. Downs JL, Mattison JA, Ingram DK, Urbanski HF. Effect of age and caloric restriction on circadian adrenal steroid rhythms in rhesus macaques. Neurobiol Aging. 2008;29(9):1412-1422.

  6. Ebersole JL, Steffen MJ, Reynolds MA, Branch-Mays GL, Dawson DR, Novak KF, Gunsolley JC, Mattison JA, Ingram DK, Novak MJ. Differential gender effects of a reduced-calorie diet on systemic inflammatory and immune parameters in nonhuman primates. J Periodontal Res. 2008 June. [Epub ahead of print].

  7. Firestein R, Blander G, Michan S, Oberdoerffer P, Ogino S, Campbell J, Bhimavarapu A, Luikenhuis S, de Cabo R, Fuchs C, Hahn WC, Guarente LP, Sinclair DA. The SIRT1 deacetylase suppresses intestinal tumorigenesis and colon cancer growth. PLoS ONE. 2008;3(4):e2020.

  8. Gouras P, Ivert L, Landauer N, Mattison JA, Ingram DK, Neuringer M. Drusenoid maculopathy in rhesus monkeys (Macaca mulatta): effects of age and gender. Graefes Arch Clin Exp Ophthalmol. 2008 August. [Epub ahead of print].

  9. Gouras P, Ivert L, Mattison JA, Ingram DK, Neuringer M. Drusenoid maculopathy in rhesus monkeys: autofluorescence, lipofuscin and drusen pathogenesis. Graefes Arch Clin Exp Ophthalmol. 2008 August. [Epub ahead of print].

  10. Komatsu T, Chiba T, Yamaza H, Yamashita K, Shimada A, Hoshiyama Y, Henmi T, Ohtani H, Higami Y, de Cabo R, Ingram DK, Shimokawa I. Manipulation of caloric content but not diet composition, attenuates the deficit in learning and memory of senescence-accelerated mouse strain P8. Exp Gerontol. 2008;43(4):339-346.

  11. Martin B, Pearson M, Brenneman R, Golden E, Keselman A, Iyun T, Carlson OD, Egan JM, Becker KG, Wood W 3rd, Prabhu V, de Cabo R, Maudsley S, Mattson MP. Conserved and differential effects of dietary energy intake on the hippocampal transcriptomes of females and males. PLoS ONE. 2008;3(6):e2398.

  12. Minor RK, Villarreal J, McGraw M, Percival SS, Ingram DK, de Cabo R. Calorie restriction alters physical performance but not cognition in two models of altered neuroendocrine signaling. Behav Brain Res. 2008;189(1):202-211.

  13. Pearson KJ, Baur JA, Lewis KN, Peshkin L, Price NL, Labinskyy N, Swindell WR, Kamara D, Minor RK, Perez E, Jamieson HA, Zhang Y, Dunn SR, Sharma K, Pleshko N, Woollett LA, Csiszar A, Ikeno Y, Le Couteur D, Elliott PJ, Becker KG, Navas P, Ingram DK, Wolf NS, Ungvari Z, Sinclair DA, de Cabo R. Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life span. Cell Metab. 2008 July. [Epub ahead of print].

  14. Pearson KJ, Lewis KN, Price NL, Chang JW, Perez E, Cascajo MV, Tamashiro KL, Poosala S, Csiszar A, Ungvari Z, Kensler TW, Yamamoto M, Egan JM, Longo DL, Ingram DK, Navas P, de Cabo R. Nrf2 mediates cancer protection but not prolongevity induced by caloric restriction. Proc Natl Acad Sci USA. 2008;105(7):2325-2330.

  15. Rapp, PR: Aging and memory: animals. In: Encyclopedia of Neuroscience, L.R. Squire et al., eds. In press.

  16. Rapp PR, and Bachevalier J: Cognitive development and aging. In: Fundamental Neuroscience, 3rd Edition, L.R. Squire et al., eds., Academic Press: San Diego, in press, 2008.

  17. Reynolds MA, Dawson DR, Novak KF, Ebersole JL, Gunsolley JC, Branch-Mays GL, Holt SC, Mattison JA, Ingram DK, Novak MJ. Effects of caloric restriction on inflammatory periodontal disease. Nutrition (in press).

  18. Shalman R, Kanfi Y, Pilosof SN, Pearson KJ, Gozlan YM, Lerrer B, Marine JC, Moazed D, de Cabo R, and Cohen HY. Regulation of SIRT6 protein levels by nutrient availability. FEBS Lett. 2008;582(5):543-548.

  19. Zhang W, Zou S, Song J. Term-tissue specific models for prediction of gene ontology biological processes using transcriptional profiles of aging in drosophila melanogaster. BMC Bioinformatics. 2008;9(1):129.

  20. Devan BD, Pistell PJ, Daffin LW Jr, Nelson CM, Duffy KB, Bowker JL, Bharati IS, Sierra-Mercado D, Spangler EL, Ingram DK. Sildenafil citrate attenuates a complex maze impairment induced by intracerebroventricular infusion of the NOS inhibitor Nomega-nitro-L-arginine methyl ester. Eur J Pharmacol. 2007;563(1-3):134-140. [Abs]

  21. Downs JL, Mattison JA, Ingram DK, Urbanski HF. Effect of age and caloric restriction on circadian adrenal steroid rhythms in rhesus macaques. Neurobiol Aging. 2007 April; [Epub ahead of print]. [Abs]

  22. Duffy KB, Spangler EL, Devan BD, Guo Z, Bowker JL, Janas AM, Hagepanos A, Minor RK, Decabo R, Mouton PR, Shukitt-Hale B, Joseph JA, Ingram DK. A blueberry-enriched diet provides cellular protection against oxidative stress and reduces a kainate-induced learning impairment in rats. Neurobiol Aging. 2007 May; [Epub ahead of print]. [Abs]

  23. He HJ, Pires R, Zhu TN, Zhou AH, Gaigalas AK, Zou S*, Wang L. * (*co-corresponding authors). A fluorescence resonance energy transfer based method for detection of DNA binding activities of nuclear factor kappaB. Biotechniques. 2007;43:93-98.

  24. Hyun DH, Hunt ND, Emerson SS, Hernandez JO, Mattson MP, Cabo RD. Up-regulation of plasma membrane-associated redox activities in neuronal cells lacking functional mitochondria. J Neurochem. 2007;100(5):1364-1374. [Abs]

  25. Ingram DK, Young J, Mattison JA. Calorie restriction in nonhuman primates: assessing effects on brain and behavioral aging. Neuroscience. 2007;145(4):1359-1364. [Abs]

  26. Jamieson HA, Cogger VC, Twigg SM, McLennan SV, Warren A, Cheluvappa R, Hilmer SN, Fraser R, de Cabo R, Le Couteur DG. Alterations in liver sinusoidal endothelium in a baboon model of type 1 diabetes. Diabetologia. 2007;50(9):1969-1976. [Abs]

  27. Jamieson HA, Hilmer SN, Cogger VC, Warren A, Cheluvappa R, Abernethy DR, Everitt AV, Fraser R, de Cabo R, Le Couteur DG. Caloric restriction reduces age-related pseudocapillarization of the hepatic sinusoid. Exp Gerontol. 2007;42(4):374-378. [Abs]

  28. Lane MA, Roth GS, Ingram DK. Caloric restriction mimetics: a novel approach for biogerontology. Methods Mol Biol. 2007;371:143-149.

  29. Mattison JA, Ottinger MA, Powell D, Longo DL, Ingram DK. Endometriosis: clinical monitoring and treatment procedures in rhesus monkeys. J Med Primatol. 2007; In press.

  30. Mattison JA, Roth GS, Lane MA, Ingram DK. Dietary restriction in aging nonhuman primates. Interdiscip Top Gerontol. 2007;35:137-158. [Abs]

  31. Moore CM, Dunn BG, McMahan CA, Lane MA, Roth GS, Ingram, DK, Mattison JA. Effects of caloric restriction in chromosomal stability in rhesus monkeys (Macaca mulatta). AGE: J Am Aging Assoc. 2007;29:15-28.

  32. Navas P, Villalba JM, de Cabo R. The importance of plasma membrane coenzyme Q in aging and stress responses. Mitochondrion. 2007;7 Suppl:S34-40. [Abs]

  33. Norgate M, Southon A, Zou S, Zhan M, Sun Y, Batterham P, Camakaris J. Copper homeostasis gene discovery in Drosophila melanogaster. Biometals. 2007;20(3-4):683-697. [Abs]

  34. O'Neil JN, Mouton PR, Tizabi Y, Ottinger MA, Lei DL, Ingram DK, Manaye KF. Catecholaminergic neuronal loss in locus coeruleus of aged female dtg APP/PS1 mice. J Chem Neuroanat. 2007 May; [Epub ahead of print].

  35. Stote KS, Baer DJ, Spears K, Paul DR, Harris GK, Rumpler WV, Strycula P, Najjar SS, Ferrucci L, Ingram DK, Longo DL, Mattson MP. A controlled trial of reduced meal frequency without caloric restriction in healthy, normal-weight, middle-aged adults. Am J Clin Nutr. 2007;85(4):981-988.

  36. Utsuki T, Uchimura N, Irikura M, Moriuchi H, Holloway HW, Yu QS, Spangler EL, Mamczarz J, Ingram DK, Irie T, Greig NH. Pre-clinical investigation of the topical administration of phenserine: transdermal flux, cholinesterase inhibition and cognitive efficacy. J Pharmacol Exp Ther. 2007;321(1):353-361. [Abs]

  37. Zhan M, Yamaza H, Sun Y, Sinclair J, Li H, Zou S. Temporal and spatial transcriptional profiles of aging in Drosophila melanogaster. Genome Res. 2007;17(8):1236-1243.

  38. Zhu M, Lee GD, Ding L, Hu J, Qiu G, de Cabo R, Bernier M, Ingram DK, Zou S. Adipogenic signaling in rat white adipose tissue: Modulation by aging and calorie restriction. Exp Gerontol. 2007;42(8):733-744.

  39. Zou S, Sinclair J, Wilson MA, Carey JR, Liedo P, Oropeza A, Kalra A, de Cabo R, Ingram DK, Longo DL, Wolkow CA. Comparative approaches to facilitate the discovery of prolongevity interventions: Effects of tocopherols on lifespan of three invertebrate species. Mech Ageing Dev. 2007;128(2):222-226. [Abs]

  40. Baur JA, Pearson KJ, Price NL, Jamieson HA, Lerin C, Kalra A, Prabhu VV, Allard JS, Lopez-Lluch G, Lewis K, Pistell PJ, Poosala S, Becker KG, Boss O, Gwinn D, Wang M, Ramaswamy S, Fishbein KW, Spencer RG, Lakatta EG, Le Couteur D, Shaw RJ, Navas P, Puigserver P, Ingram DK, de Cabo R, Sinclair DA. Resveratrol improves health and survival of mice on a high-calorie diet. Nature. 2006;444(7117):337-342. [Abs]

  41. Bernier M, Kwon YK, Pandey SK, Zhu TN, Zhao RJ, Maciuk A, He HJ, de Cabo R, Kole S. Binding of manumycin A inhibits Ik B kinase b activity. J Biol Chem. 2006;281(5):2551-2561. [Abs]

  42. de Cabo R, Burgess JR, Navas P. Adaptations to oxidative stress induced by vitamin E deficiency in rat liver. J Bioenerg Biomembr. 2006;38(5-6):309-317. [Abs]

  43. Devan BD, Bowker JL, Duffy KB, Bharati IS, Jimenez M, Sierra-Mercado D Jr, Nelson CM, Spangler EL, Ingram DK. Phosphodiesterase inhibition by sildenafil citrate attenuates a maze learning impairment in rats induced by nitric oxide synthase inhibition. Psychopharmacology (Berl). 2006;183(4):439-445. [Abs]

  44. Hunt ND, Hyun DH, Allard JS, Minor RK, Mattson MP, Ingram DK, de Cabo R. Bioenergetics of aging and calorie restriction. Ageing Res Rev. 2006;5(2):125-143. [Abs]

  45. Hyun DH, Emerson SS, Jo DG, Mattson MP, de Cabo R. Calorie restriction up-regulates the plasma membrane redox system in brain cells and suppresses oxidative stress during aging. Proc Natl Acad Sci USA. 2006;103(52):19908-19912. [Abs]

  46. Hyun DH, Hernandez JO, Mattson MP, de Cabo R. The plasma membrane redox system in aging. Ageing Res Rev. 2006;5(2):209-220. [Abs]

  47. Ingram DK, Roth GS, Lane MA, Ottinger MA, Zou S, de Cabo R, Mattison JA. The potential for dietary restriction to increase longevity in humans: extrapolation from monkey studies. Biogerontology. 2006;7:143-148. [Abs]

  48. Ingram DK, Zhu M, Mamczarz J, Zou S, Lane MA, Roth GS, de Cabo R. Calorie restriction mimetics: an emerging research field. Aging Cell. 2006;5(2):97-108. [Abs]

  49. Lee GD, Longo DL, Wang Y, Rifkind JM, Abdul-Raman L, Mamczarz JA, Duffy KB, Spangler EL, Taub DD, Mattson MP, Ingram DK. Transient improvement in cognitive function and synaptic plasticity in rats following cancer chemotherapy. Clin Cancer Res. 2006;12(1):198-205. [Abs]

  50. Lee GD, Wilson MA, Zhu M, Wolkow CA, de Cabo R, Ingram DK, Zou S. Dietary deprivation extends lifespan in Caenorhabditis elegans. Aging Cell. 2006;5(6):515-524. [Abs]

  51. Liu D, Chan SL, de Souza-Pinto NC, Slevin JR, Wersto RP, Zhan M, Mustafa K, de Cabo R, Mattson MP. Mitochondrial UCP4 mediates an adaptive shift in energy metabolism and increases the resistance of neurons to metabolic and oxidative stress. Neuromolecular Med. 2006;8(3):389-414. [Abs]

  52. Lopez-Lluch G, Hunt N, Jones B, Zhu M, Jamieson H, Hilmer S, Cascajo MV, Allard J, Ingram DK, Navas P, de Cabo R. Calorie restriction induces mitochondrial biogenesis and bioenergetic efficiency. Proc Natl Acad Sci USA. 2006;103(6):1768-1773. [Abs]

  53. Messaoudi I, Warner J, Fischer M, Park B, Hill B, Mattison J, Lane MA, Roth GS, Ingram DK, Picker LJ, Douek DC, Mori M, Nikolich-Zugich J. Delay of T cell senescence by caloric restriction in aged long-lived nonhuman primates. Proc Natl Acad Sci USA. 2006;103(51):19448-11953. [Abs]

  54. Perry TA, Holloway HW, Weerasuriya A, Mouton, PR, Duffy K, Mattison JA, Greig NH. Evidence of GLP-1 mediated neuroprotection in an animal model of pyridoxine-induced peripheral sensory neuropathy. 2006;203(2):293-301. [Abs]

  55. Qin W, Chachich M, Lane M, Roth G, Bryant M, de Cabo R, Ottinger MA, Mattison J, Ingram D, Gandy S, Pasinetti GM. Calorie restriction attenuates Alzheimer's disease type brain amyloidosis in Squirrel monkeys (Saimiri sciureus). J Alzheimers Dis. 2006;10(4):417-422. [Abs]

  56. Umegaki H, Yamaguchi Y, Ishiwata K, Ingram DK, Roth GS, Iguchi A. Functional recovery of the striatal cholinergic system in aged rats by adenoviral vector-mediated gene transfer of dopamine D(2) receptor. Mech Ageing Dev. 2006;127(10):813-815. [Abs]

  57. Wang Y, Mackes J, Chan S, Haughey NJ, Guo Z, Ouyang X, Furukawa K, Ingram DK, Mattson MP. Impaired long-term depression in P2X3 deficient mice is not associated with a spatial learning deficit. J Neurochem. 2006;99(5):1425-1434. [Abs]

  58. Wilson MA, Shukitt-Hale B, Kalt W, Ingram DK, Joseph JA, Wolkow CA. Blueberry polyphenols increase lifespan and thermotolerance in Caenorhabditis elegans. Aging Cell. 2006;5(1):59-68. [Abs]

  59. Anisimov VN, Ukraintseva SV, Anikin IV, Popovich IG, Zabezhinski MA, Bertsein LM, Arutjunyan AV, Ingram DK, Lane MA, Roth GS. Effects of phentermine and phenformin on biomarkers of aging in rats. Gerontology. 2005;51(1):19-28. [Abs]

  60. Greig NH, Utsuki T, Ingram DK, Wang Y, Pepeu G, Scali C, Yu QS, Mamczarz J, Holloway HW, Giordano T, Chen D, Furukawa K, Sambamurti K, Brossi A, Lahiri DK. Selective butyrylcholinesterase inhibition elevates brain acetylcholine, augments learning and lowers Alzheimer beta-amyloid peptide in rodent. Proc Natl Acad Sci USA. 2005;102(47):17213-17218. [Abs]

  61. Janas AM, Cunningham SC, Duffy KB, Devan BD, Greig NH, Holloway HW, Yu QS, Markowska AL, Ingram DK, Spangler EL. The cholinesterase inhibitor, phenserine, improves Morris water maze performance of scopolamine-treated rats. Life Sci. 2005;76(10):1073-1081. [Abs]

  62. Lee GD, Aruna JH, Barrett PM, Lei DL, Ingram DK, Mouton PR. Stereological analysis of microvascular parameters in a double transgenic model of Alzheimer's disease. Brain Res Bull. 2005;65(4):317-322. [Abs]

  63. Mamczarz J, Bowker JL, Duffy K, Zhu M, Hagepanos A, Ingram DK. Enhancement of amphetamine-induced locomotor response in rats on different regimens of diet restriction and 2-deoxy-d-glucose treatment. Neuroscience. 2005;131(2):451-464. [Abs]

  64. Mattison JA, Black A, Huck J, Moscrip T, Handy A, Tilmont E, Roth GS, Lane MA, Ingram DK. Age-related decline in caloric intake and motivation for food in rhesus monkeys. Neurobiol Aging. 2005;26(7):1117-1127. [Abs]

  65. Ottinger MA, Mobarak M, Abdelnabi M, Roth G, Proudman J, Ingram DK. Effects of calorie restriction on reproductive and adrenal systems in Japanese quail: are responses similar to mammals, particularly primates? Mech Ageing Dev. 2005;126(9):967-975. [Abs]

  66. Ravi LB, Poosala S, Ahn D, Chrest FJ, Spangler EL, Jayakumar R, Nagababu E, Mohanty JG, Talan M, Ingram DK, Rifkind JM. Red cell interactions with amyloid-b1-40 fibrils in a murine model. Neurobiol Dis. 2005;19(1-2):28-37. [Abs]

  67. Roth GS, Lane MA, Ingram DK. Caloric restriction mimetics: the next phase. Ann NY Acad Sci. 2005;1057:365-371. [Abs]

  68. Wu JM, Zelinski MB, Ingram DK, Ottinger MA. Ovarian aging and menopause: current theories, hypotheses, and research models. Exp Biol Med (Maywood). 2005;230(11):818-828. [Abs]

  69. Zhu M, de Cabo R, Anson RM, Ingram DK, Lane MA. Caloric restriction modulates insulin receptor signaling in liver and skeletal muscle of rat. Nutrition. 2005;21(3):378-388. [Abs]

  70. Bondolfi L, Ermini F, Long JM, Ingram DK, Jucker M. Impact of age and caloric restriction on neurogenesis in the dentate gyrus of C57BL/6 mice. Neurobiol Aging. 2004;25(3):333-340. [Abs]

  71. de Cabo R, Cabello R, Rios M, Lopez-Lluch G, Ingram DK, Lane MA, Navas P. Calorie restriction attenuates age-related alterations in the plasma membrane antioxidant system in rat liver. Exp Gerontol. 2004;39(3):297-304. [Abs]

  72. Devan BD, Sierra-Mercado D Jr, Jimenez M, Bowker JL, Duffy KB, Spangler EL, Ingram DK. Phosphodiesterase inhibition by sildenafil citrate attenuates the learning impairment induced by blockade of cholinergic muscarinic receptors in rats. Pharmacol Biochem Behav. 2004;79(4):691-699. [Abs]

  73. Ingram DK, Anson RM, de Cabo R, Mamczarz J, Zhu M, Mattison J, Lane MA, Roth GS. Development of calorie restriction mimetics as a prolongevity strategy. Ann NY Acad Sci. 2004;1019:412-423. [Abs]

  74. Lane MA, de Cabo R, Mattison J, Anson RM, Roth GS, Ingram DK. The Roy Walford legacy: diet restriction from molecules to mice to monkeys to man and onto mimetics. Exp Gerontol. 2004;39(6):897-902. [Abs]

  75. Lane MA, Mattison JA, Roth GS, Brant LJ, Ingram DK. Effects of long-term diet restriction on aging and longevity in primates remain uncertain. J Gerontol A Biol Sci Med Sci. 2004;59(5):405-407. [Abs]

  76. Maswood N, Young J, Tilmont E, Zhang Z, Gash DM, Gerhardt GA, Grondin R, Roth GS, Mattison J, Lane MA, Carson RE, Cohen RM, Mouton PR, Quigley C, Mattson MP, Ingram DK. Caloric restriction increases neurotrophic factor levels and attenuates neurochemical and behavioral deficits in a primate model of Parkinson's disease. Proc Natl Acad Sci USA. 2004;101(52):18171-18176. [Abs]

  77. Matochik JA, Chefer SI, Lane MA, Roth GS, Mattison JA, London ED, Ingram DK. Age-related decline in striatal volume in rhesus monkeys: assessment of long-term calorie restriction. Neurobiol Aging. 2004;25(2):193-200. [Abs]

  78. McDonald RJ, Hong NS, Devan BD. The challenges of understanding mammalian cognition and memory-based behaviours: an interactive learning and memory systems approach. Neurosci Biobehav Rev. 2004;28(7):719-745. [Abs]

  79. Roth GS, Mattison JA, Ottinger MA, Chachich ME, Lane MA, Ingram DK. Aging in rhesus monkeys: relevance to human health interventions. Science. 2004;305(5689):1423-1426. [Abs]

  80. Smucny DA, Allison DB, Ingram DK, Roth GS, Kemnitz JW, Kohama SG, Lane MA, Black A. Changes in blood chemistry and hematology variables during aging in captive rhesus macaques (Macaca mulatta)-(J Med Primatol 30:161-173, 2001). J Med Primatol. 2004;33(1):48-54. [Abs]

  81. Torre P 3rd, Mattison JA, Fowler CG, Lane MA, Roth GS, Ingram DK. Assessment of auditory function in rhesus monkeys (Macaca mulatta): effects of age and calorie restriction. Neurobiol Aging. 2004;25(7):945-954. [Abs]

  82. Wang Y, Chan SL, Miele L, Yao PJ, Mackes J, Ingram DK, Mattson MP, Furukawa K. Involvement of Notch signaling in hippocampal synaptic plasticity. Proc Natl Acad Sci USA. 2004;101(25):9458-9462. [Abs]

  83. Urbanski HF, Downs JL, Garyfallou VT, Mattison JA, Lane MA, Roth GS, Ingram DK. Effect of caloric restriction on the 24-hour plasma DHEAS and cortisol profiles of young and old male rhesus macaques. Ann NY Acad Sci. 2004;1019:443-447. [Abs]

  84. Vega VL, De Cabo R, De Maio A. Age and caloric restriction diets are confounding factors that modify the response to lipopolysaccharide by peritoneal macrophages in C57BL/6 mice. Shock. 2004;22(3):248-253. [Abs]

  85. Zhu M, de Cabo R, Lane MA, Ingram DK. Caloric restriction modulates early events in insulin signaling in liver and skeletal muscle of rat. Ann NY Acad Sci. 2004;1019:448-452. [Abs]

  86. Zhu M, Miura J, Lu LX, Bernier M, DeCabo R, Lane MA, Roth GS, Ingram DK. Circulating adiponectin levels increase in rats on caloric restriction: the potential for insulin sensitization. Exp Gerontol. 2004;39(7):1049-1059. [Abs]

  87. Anson RM, Guo Z, de Cabo R, Iyun T, Rios M, Hagepanos A, Ingram DK, Lane MA, Mattson MP. Intermittent fasting dissociates beneficial effects of dietary restriction on glucose metabolism and neuronal resistance to injury from calorie intake. Proc Natl Acad Sci USA. 2003;100(10): 6216-6220. [Abs]

  88. Atwood CS, Barzilai N, Bowen RL, Brown-Borg HM, Jarrard DF, Fu VX, Heilbronn LK, Ingram DK, Ravussin E, Schwartz RS, Weindruch R. Pennington scientific symposium on mechanisms and retardation of aging. Exp Gerontol. 2003;38(10):1217-1226. [Abs]

  89. Lahiri DK, Chen D, Ge YW, Farlow M, Kotwal G, Kanthasamy A, Ingram DK, Greig NH. Does nitric oxide synthase contribute to the pathogenesis of Alzheimer's disease? Effects of b-amyloid deposition on NOS in transgenic mouse brain with AD pathology. Ann NY Acad Sci. 2003;1010:639-642. [Abs]

  90. Lei DL, Long JM, Hengemihle J, O'Neill J, Manaye KF, Ingram DK, Mouton PR. Effects of estrogen and raloxifene on neuroglia number and morphology in the hippocampus of aged female mice. Neuroscience. 2003;121(3):659-666. [Abs]

  91. Mattison JA, Lane MA, Roth GS, Ingram DK. Calorie restriction in Rhesus monkeys. Exp Gerontol. 2003;38(1-2):35-46. [Abs]

  92. Sell DR, Lane MA, Obrenovich ME, Mattison JA, Handy A, Ingram DK, Cutler RG, Roth GS, Monnier VM. The effect of caloric restriction on glycation and glycoxidation in skin collagen of nonhuman primates. J Gerontol A Biol Sci Med Sci. 2003;58(6):508-516. [Abs]

  93. Umegaki H, Ishiwata K, Ogawa O, Ingram DK, Roth GS, Oda K, Kurotani S, Kawamura K, Wang WF, Ikari H, Senda M, Iguchi A. Longitudinal follow-up study of adenoviral vector-mediated gene transfer of dopamine D2 receptors in the striatum in young, middle-aged, and aged rats: a positron emission tomography study. Neuroscience. 2003;121(2):479-486. [Abs]

  94. Bartke A, Wright JC, Mattison JA, Ingram DK, Miller RA, Roth GS. Dietary restriction and life-span. Science. 2002;296(5576):2141-2142. [Abs]

  95. Black A, Lane MA. Nonhuman primate models of skeletal and reproductive aging. Gerontology. 2002;48(2):72-80. [Abs]

  96. Lahiri DK, Utsuki T, Chen D, Farlow MR, Shoaib M, Ingram DK, Greig NH. Nicotine reduces the secretion of Alzheimer's b-amyloid precursor protein containing b-amyloid peptide in the rat without altering synaptic proteins. Ann NY Acad Sci. 2002;965:364-372. [Abs]

  97. Lane MA, Ingram DK, Roth GS. The serious search for an anti-aging pill. Sci Am. 2002;287(2):36-41. [Abs]

  98. Lane MA, Mattison J, Ingram DK, Roth GS. Caloric restriction and aging in primates: Relevance to humans and possible CR mimetics. Microsc Res Tech. 2002;59(4):335-338. [Abs]

  99. Lee J, Chan SL, Lu C, Lane MA, Mattson MP. Phenformin suppresses calcium responses to glutamate and protects hippocampal neurons against excitotoxicity. Exp Neurol. 2002;175(1):161-167. [Abs]

  100. Luo Y, Long JM, Lu C, Chan SL, Spangler EL, Mascarucci P, Raz A, Longo DL, Mattson MP, Ingram DK, Weng NP. A link between maze learning and hippocampal expression of neuroleukin and its receptor gp78. J Neurochem. 2002;80(2):354-361. [Abs]

  101. Mascarucci P, Taub D, Saccani S, Paloma MA, Dawson H, Roth GS, Lane MA, Ingram DK. Cytokine responses in young and old Rhesus monkeys: effect of caloric restriction. J Interferon Cytokine Res. 2002;22(5):565-571. [Abs]

  102. Mouton PR, Long JM, Lei DL, Howard V, Jucker M, Calhoun ME, Ingram DK. Age and gender effects on microglia and astrocyte numbers in brains of mice. Brain Res. 2002;956(1):30-35. [Abs]

  103. Roth GS, Handy AM, Mattison JA, Tilmont EM, Ingram DK, Lane MA. Effects of dietary caloric restriction and aging on thyroid hormones of Rhesus monkeys. Horm Metab Res. 2002;34(7):378-382. [Abs]

  104. Roth GS, Lane MA, Ingram DK, Mattison JA, Elahi D, Tobin JD, Muller D, Metter EJ. Biomarkers of caloric restriction may predict longevity in humans. Science. 2002;297(5582):811. [Abs]

  105. Spangler EL, Patel N, Speer D, Hyman M, Hengemihle J, Markowska A, Ingram DK. Passive avoidance and complex maze learning in the senescence accelerated mouse (SAM): age and strain comparisons of SAM P8 and R1. J Gerontol A Biol Sci Med Sci. 2002;57(2):B61-B68. [Abs]

  106. Umegaki H, Ishiwata K, Ogawa O, Ingram DK, Roth GS, Yoshimura J, Oda K, Matsui-Hirai H, Ikari H, Iguchi A, Senda M. In vivo assessment of adenoviral vector-mediated gene expression of dopamine D2 receptors in the rat striatum by positron emission tomography. Synapse. 2002;43(3):195-200. [Abs]

  107. Utsuki T, Shoaib M, Holloway HW, Ingram DK, Wallace WC, Haroutunian V, Sambamurti K, Lahiri DK, Greig NH. Nicotine lowers the secretion of the Alzheimer's amyloid b-protein precursor that contains amyloid b-peptide in rat. J Alzheimers Dis. 2002;4(5):405-415. [Abs]

  108. Bartke A, Wright JC, Mattison JA, Ingram DK, Miller RA, Roth GS. Extending the lifespan of long-lived mice. Nature. 2001;414(6862):412. [Abs]

  109. Black A, Allison DB, Shapses SA, Tilmont EM, Handy AM, Ingram DK, Roth GS, Lane MA. Calorie restriction and skeletal mass in Rhesus monkeys (Macaca mulatta): evidence for an effect mediated through changes in body size. J Gerontol A Biol Sci Med Sci. 2001;56(3):B98-B107. [Abs]

  110. Black A, Tilmont EM, Baer DJ, Rumpler WV, Ingram DK, Roth GS, Lane MA. Accuracy and precision of dual-energy X-ray absorptiometry for body composition measurements in Rhesus monkeys. J Med Primatol. 2001;30(2):94-99. [Abs]

  111. Black A, Tilmont EM, Handy AM, Scott WW, Shapses SA, Ingram DK, Roth GS, Lane MA. A nonhuman primate model of age-related bone loss: a longitudinal study in male and premenopausal female Rhesus monkeys. Bone. 2001;28(3):295-302. [Abs]

  112. Greig NH, Utsuki T, Yu Q, Zhu X, Holloway HW, Perry T, Lee B, Ingram DK, Lahiri DK. A new therapeutic target in Alzheimer's disease treatment: attention to butyrylcholinesterase. Curr Med Res Opin. 2001;17(3):159-165. [Abs]

  113. Hadley EC, Dutta C, Finkelstein J, Harris TB, Lane MA, Roth GS, Sherman SS, Starke-Reed PE. Human implications of caloric restriction's effects on aging in laboratory animals: an overview of opportunities for research. J Gerontol A Biol Sci Med Sci. 2001;56 Spec No 1:5-6. [Abs]

  114. Ingram DK. Vaccine development for Alzheimer's disease: a shot of good news. Trends Neurosci. 2001;24(6):305-307. [Abs]

  115. Ingram DK, Chefer S, Matochik J, Moscrip TD, Weed J, Roth GS, London ED, Lane MA. Aging and caloric restriction in nonhuman primates: behavioral and in vivo brain imaging studies. Ann NY Acad Sci. 2001;928:316-326. [Abs]

  116. Ingram DK, Nakamura E, Smucny D, Roth GS, Lane MA. Strategy for identifying biomarkers of aging in long-lived species. Exp Gerontol. 2001;36(7):1025-1034. [Abs]

  117. Lane MA, Black A, Handy AM, Shapses SA, Tilmont EM, Kiefer TL, Ingram DK, Roth GS. Energy restriction does not alter bone mineral metabolism or reproductive cycling and hormones in female Rhesus monkeys. J Nutr. 2001;131(3):820-827. [Abs]

  118. Lane MA, Black A, Handy A, Tilmont EM, Ingram DK, Roth GS. Caloric restriction in primates. Ann NY Acad Sci. 2001;928:287-295. [Abs]

  119. Luo Y, Long JM, Spangler EL, Longo DL, Ingram DK, Weng NP. Identification of maze learning-associated genes in rat hippocampus by cDNA microarray. J Mol Neurosci. 2001;17(3):397-404. [Abs]

  120. Mascarucci P, Taub D, Saccani S, Paloma MA, Dawson H, Roth GS, Ingram DK, Lane MA. Age-related changes in cytokine production by leukocytes in Rhesus monkeys. Aging (Milano). 2001;13(2):85-94. [Abs]

  121. Roberts SB, Pi-Sunyer X, Kuller L, Lane MA, Ellison P, Prior JC, Shapses S. Physiologic effects of lowering caloric intake in nonhuman primates and nonobese humans. J Gerontol A Biol Sci Med Sci. 2001;56 Spec No 1:66-75. [Abs]

  122. Roth GS, Ingram DK, Lane MA. Caloric restriction in primates and relevance to humans. Ann NY Acad Sci. 2001;928:305-315. [Abs]

  123. Roth GS, Lesnikov V, Lesnikov M, Ingram DK, Lane MA. Dietary caloric restriction prevents the age-related decline in plasma melatonin levels of Rhesus monkeys. J Clin Endocrinol Metab. 2001;86(7):3292-3295. [Abs]

  124. Smucny DA, Allison DB, Ingram DK, Roth GS, Kemnitz JW, Kohama SG, Lane MA. Changes in blood chemistry and hematology variables during aging in captive Rhesus macaques (Macaca mulatta). J Med Primatol. 2001;30(3):161-173. [Abs]

  125. Thanos PK, Volkow ND, Freimuth P, Umegaki H, Ikari H, Roth G, Ingram DK, Hitzemann R. Overexpression of dopamine D2 receptors reduces alcohol self-administration. J Neurochem. 2001;78(5):1094-1103. [Abs]

  126. Umegaki H, Munoz J, Meyer RC, Spangler EL, Yoshimura J, Ikari H, Iguchi A, Ingram DK. Involvement of dopamine D2 receptors in complex maze learning and acetylcholine release in ventral hippocampus of rats. Neuroscience. 2001;103(1):27-33. [Abs]

  127. Vaitkevicius PV, Lane M, Spurgeon H, Ingram DK, Roth GS, Egan JJ, Vasan S, Wagle DR, Ulrich P, Brines M, Wuerth JP, Cerami A, Lakatta EG. A cross-link breaker has sustained effects on arterial and ventricular properties in older Rhesus monkeys. Proc Natl Acad Sci USA. 2001;98(3):1171-1175. [Abs]

  128. Weindruch R, Keenan KP, Carney JM, Fernandes G, Feuers RJ, Floyd RA, Halter JB, Ramsey JJ, Richardson A, Roth GS, Spindler SR. Caloric restriction mimetics: metabolic interventions. J Gerontol A Biol Sci Med Sci. 2001;56 Spec No 1:20-33. [Abs]

  129. Ajmani RS, Metter EJ, Jaykumar R, Ingram DK, Spangler EL, Abugo OO, Rifkind JM. Hemodynamic changes during aging associated with cerebral blood flow and impaired cognitive function. Neurobiol Aging. 2000;21(2):257-269. [Abs]

  130. Greig NH, De Micheli E, Holloway HW, Yu QS, Utsuki T, Perry TA, Brossi A, Ingram DK, Deutsch J, Lahiri DK, Soncrant TT. The experimental Alzheimer drug phenserine: preclinical pharmacokinetics and pharmacodynamics. Acta Neurol Scand Suppl. 2000;176:74-84. [Abs]

  131. Henry CJ, Ritz P, Roth GS, Lane M, Solomons NW. Report of the IDECG Working Group on the biology of aging. The International Dietary Energy Consultative Group. Eur J Clin Nutr. 2000;54 Suppl 3:S157-S159. [Abs]

  132. Hutter D, Yo Y, Chen W, Liu P, Holbrook NJ, Roth GS, Liu Y. Age-related decline in Ras/ERK mitogen-activated protein kinase cascade is linked to a reduced association between Shc and EGF receptor. J Gerontol A Biol Sci Med Sci. 2000;55(3): B125-B134. [Abs]

  133. Ingram DK. Age-related decline in physical activity: generalization to nonhumans. Med Sci Sports Exerc. 2000;32(9):1623-1629. [Abs]

  134. Ingram DK, Roth GS, Umegaki H, Ikari H. Development of an adenoviral vector for intracerebral delivery of the dopamine D2 receptor. Mech Ageing Dev. 2000;116:77-93. [Abs]

  135. Jucker M, Bondolfi L, Calhoun ME, Long JM, Ingram DK. Structural brain aging in inbred mice: potential for genetic linkage. Exp Gerontol. 2000;35:1383-1388. [Abs]

  136. Kalehua AN, Taub DD, Baskar PV, Hengemihle J, Munoz J, Trambadia M, Speer DL, De Simoni MG, Ingram DK. Aged mice exhibit greater mortality concomitant to increased brain and plasma TNF-a levels following intracerebroventricular injection of lipopolysaccharide. Gerontology. 2000;46(3):115-128. [Abs]

  137. Lane MA. Nonhuman primate models in biogerontology. Exp Gerontol. 2000;35:533-541. [Abs]

  138. Lane MA, Tilmont EM, De Angelis H, Handy A, Ingram DK, Kemnitz JW, Roth GS. Short-term calorie restriction improves disease-related markers in older male Rhesus monkeys (Macaca mulatta). Mech Ageing Dev. 2000;112:185-196. [Abs]

  139. Lee J, Duan W, Long JM, Ingram DK, Mattson MP. Dietary restriction increases survival of newly-generated neural cells and induces BDNF expression in the dentate gyrus of rats. J Mol Neurosci. 2000;15:99-108. [Abs]

  140. Luo Y, Roth GS. Dopamine stimulates astrocytic C6-D2L cells via tyrosine kinase and p38 MAPK activation. Ann NY Acad Sci. 2000;899:392-398. [Abs]

  141. Luo Y, Roth GS. The roles of dopamine oxidative stress and dopamine receptor signaling in aging and age-related neurodegeneration. Antioxid Redox Signal. 2000;2(3): 449-460. [Abs]

  142. Matochik JA, Chefer SI, Lane MA, Woolf RI, Morris ED, Ingram DK, Roth GS, London ED. Age-related decline in striatal volume in monkeys as measured by magnetic resonance imaging. Neurobiol Aging. 2000;21(4):591-598. [Abs]

  143. Moscrip TD, Ingram DK, Lane MA, Roth GS, Weed JL. Locomotor activity in female Rhesus monkeys: assessment of age and calorie restriction effects. J Gerontol A Biol Sci Med Sci. 2000;55(8):B373-B380. [Abs]

  144. Ogawa O, Umegaki H, Ishiwata K, Asai Y, Ikari H, Oda K, Toyama H, Ingram DK, Roth GS, Iguchi A, Senda M. In vivo imaging of adenovirus-mediated over-expression of dopamine D2 receptors in rat striatum by positron emission tomography. Neuroreport. 2000;11(4):743-748. [Abs]

  145. Roth GS, Ingram DK, Black A, Lane MA. Effects of reduced energy intake on the biology of aging: the primate model. Eur J Clin Nutr. 2000;54 Suppl 3:S15-S20. [Abs]

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