| The Laboratory of Experimental Gerontology conducts basic research in experimental models focused on interventions that retard aging processes. Currently the LEG is comprised of the NIA Primate Aging Study and two units, the Aging, Metabolism, and Nutrition Unit (AMNU) headed by Dr. Rafael de Cabo and the Functional Genomics Unit (FGU) headed by Dr. Sige Zou. One of the major projects of the LEG is a longitudinal study being conducted in nonhuman primates to examine the potential beneficial effects of calorie restriction on mortality, morbidity, and aging processes. A second major project for the laboratory is the development of a standardized research program coordinated through the NIA extramural program to evaluate various aging interventions (pharmaceuticals, hormones, dietary supplements, genes) in mouse models to assess effects on lifespan, pathology, and functional capacity at older ages. Another important activity of the BNS is to develop behavioral assays of aging in rodents and nonhuman primates with focus on motor and memory performance and to conduct research to identify mechanisms of age-related decline in motor and memory performance. As a primary objective of research in LEG, investigations are directed toward preclinical development of pharmacological, genetic, and nutritional interventions that improve function at older ages. |
