National Institute on Aging, Intramural Research Program

Sun, X.P., Seeberger, J., Alberico, T., Wang, C., Wheeler, C.T., Schauss, A.G. and Zou, S. Açai palm fruit (Euterpe oleracea Mart.) pulp improves survival of flies on a high fat diet. Experimental Gerontology 45(3):243-51, 2010. (PMC2826513)
Zou, S. * (*Corresponding authors), Carey, J.R., Liedo P., Ingram, D.K., Yu, B. and Ghaedian, R. Prolongevity effects of an oregano and cranberry extract are diet-dependent in the Mexican fruit fly (Anastrepha ludens). Journal of Gerontology Serial A: Biological Sciences. 65(1):41-50, 2010. (PMC2796885).
Zhang, D.M., Jiang, D.P., Yanney, M., Zou, S. and Sygula, A. Ratiometric raman spectroscopy for quantification of protein oxidative damage. Analytical Biochemistry. 391(2):121-6, 2009. (PMC2773654).
Zou, S.* (*Corresponding authors), Carey, J.R., Liedo P., Ingram, D.K., Müller, H.G., Wang, J.L., Yao, F., Yu, B. and Zhou, A. The prolongevity effect of resveratrol depends on dietary composition and calorie intake in a tephritid fruit fly. Experimental Gerontology 44: 472-6, 2009.
Zhang, W., Zou, S.*, Song, J.* (*co-corresponding authors). Term-tissue specific models for prediction of gene ontology biological processes using transcriptional profiles of aging in Drosophila melanogaster. BMC Bioinformatics. 9:129, 2008. (PMC2322984).
Zhan, M., Yamaza, H., Sun, Y., Sinclair, J., Li, H., Zou, S. Temporal and spatial transcriptional profiles of aging in Drosophila melanogaster. Genome Research 17 (8):1236-1243, 2007. (Highlighted in Research Highlights, Genetics: Time waits for no fly. Nature 448, 390-391) (PMC1933522).
Zhu, M., Lee, G.D., Ding, L. Hu, J.P., Qiu, G., de Cabo, R., Bernier, M., Ingram, D.K. and Zou, S.: Adipogenic Signaling in rat white adipose tissue: modulation by aging and calorie restriction. Experimental Gerontology 42: 733-744, 2007. (PMC1978194).
He, H.J., Pires, R., Zhu, T.N., Zhou, A.H., Gaigalas, A.K., Zou, S.* and Wang, L. * (*co-corresponding authors). A Fluorescence resonance energy transfer based method for detection of DNA binding activities of nuclear factor kappaB. Biotechniques 43: 93-98, 2007.
Norgate, M,, Southon, A., Zou, S., Zhan, M., Sun, Y., Batterham, P., Camakaris, J. Copper homeostasis gene discovery in Drosophila melanogaster. Biometals 20(3-4):683-697, 2007.
Zou, S.*, Sinclair, J.* (*Co-first author), Wilson, M.A., Carey, J.R., Liedo, P., Oropeza, A., Kalra, A., de Cabo, R., Ingram, D.K., Longo, D.L., Wolkow, C.A. Comparative approaches to facilitate the discovery of prolongevity interventions: Effects of tocopherols on lifespan of three invertebrate species. Mechanisms of Ageing and Development 128:222-6, 2007. (PMC1820625).
Lee, G.D., Wilson, M.A. Zhu, M., Wolkow, C.A. de Cabo, R., Ingram, D.K. and Zou, S.: Dietary deprivation extends lifespan in Caenorhabditis elegans. Aging Cell 5: 515-24, 2006. (PMC2546582).
Ingram, D.K., Roth, G.S., Lane, M.A., Ottinger, M.A., Zou, S., de Cabo, R. and Mattison, J.: The potential for dietary restriction to increase longevity in humans: extrapolation from monkey studies. Biogerontology 7 (3): 143-148, 2006.
Ingram, D.K., Zhu, M., Mamczarz, J., Zou, S., Mark A Lane, M.A., Roth, G.S. and de Cabo, R.: Calorie restriction mimetics: an emerging research field. Aging Cell 5(2): 97-108, 2006.
McCarroll, S. A., Murphy, C. T., Zou, S., Pletcher, S. D., Chin, C. S., Jan, Y. N., Kenyon, C., Bargmann, C. I. and Hao, L.: Comparing genomic expression patterns across species identifies shares transcriptional profile in aging. Nature Genetics 36: 197-204, 2004.
Zou, S., Meadows, S., Sharp, L., Jan, L.Y. and Jan, Y.N.: Genome-wide study of aging and oxidative stress response in Drosophila melanogaster. Proceedings of the National Academy of Sciences, U.S.A. 97: 13726-31, 2000.
Zhu, Y.*; Zou, S.* (*Co-first author), Wright, D.A. and Voytas, D.F.: Tagging chromatin with retrotransposons: target specificity of the Saccharomyces Ty5 retrotransposon changes with the chromosomal localization of Sir3p and Sir4p. Genes & Development 13: 2738-49, 1999.
Zou, S. and Voytas, D.F.: Silent chromatin determines integration preference of Saccharomyces retrotransposon Ty5. Proceedings of the National Academy of Sciences, U.S.A. 94: 7412-6, 1997.
Zou, S., Kim, J.M. and Voytas, D.F.: The Saccharomyces retrotransposon Ty5 influences the organization of chromosome ends. Nucleic Acids Research 24: 4825-31, 1996.
Zou, S., Ke, N., Kim, J.M. and Voytas, D.F.: The Saccharomyces retrotransposon Ty5 integrates preferentially into regions of silent chromatin at the telomeres and mating loci. Genes & Development 10: 634-45, 1996. (Cover Article).
Zou, S., Wright, D.A. and Voytas, D.F.: The Saccharomyces Ty5 retrotransposon family is associated with origin of DNA replication at the telomeres and the silent mating locus HMR. Proceedings of the National Academy of Sciences, U.S.A. 92: 920-4, 1995.

CURRICULUM VITAE
Name
Sige Zou
Present Address
Laboratory of Experimental Gerontology National Institute on Aging 251 Bayview Blvd, Suite #100 Baltimore, MD 21224-6825 Phone: 410-558-8461 Fax: 410-558-8450 E-mail: zous@mail.nih.gov
Education
1997-2003		Postdoctoral training at University of California at San Francisco. Mentor: Yuh-Nung Jan
1996		Ph.D., Iowa State University, Ames, Iowa. Programs of Molecular, Cellular and Developmental Biology Mentor: Dr. Daniel F. Voytas
1990		B.S., Fudan University, Shanghai, P.R. China Department of Genetics and Genetic Engineering Major: Genetics and Genetic Engineering
Brief Chronology of Employment
2009-Present		Adjunct Assistant Professor at Clemson University.
2004-Present		Tenure-track Investigator, Head of Functional Genomics Unit, National Institute on Aging, Baltimore, Maryland.
2004		Assistant Specialist, University of California at San Francisco, California.
2003-2004		Senior Scientist, Bio-Rad Laboratories, Hercules, California.
1997-2003		Postdoctoral Fellow, University of California at San Francisco.
1994		Teaching Assistant for Genetics 520L, Iowa State University, Ames, Iowa.
1990-1992		Technician, Fruit Development Corporation of Dongguan Dongguan, Guangdong Province, P.R. China.
Societies
The American Aging Association.
Honors and Other Special Scientific Recognition
2000-2003		Howard Hughes Medical Institute fellowship.
1997-2000		Damon Runyon-Walter Winchell Cancer Research Award.
1996		Research Excellence Award, Iowa State University.
1995		MCDB Competitive Research Fellowship, Iowa State University.
Research grants
2004-present		The Intramural Research Program at the National Institute on Aging.
2010-2011		The NIH Office of Dietary Supplements Research Grant for the proposal titled “Evaluation of the Anti-Aging Effects of an Açai Pulp Extract.”
2008-2009		The Wisconsin Cranberry Board, Inc. Award for the proposal titled “The Effects of Cranberry on Delaying Pathogenesis of a Mouse Model of Alzheimer’s Disease”.
2006-2007		The NIA Intramural Competitive Grant for the Inter-Laboratory Collaboration for the proposal titled “Molecular Mechanisms of Lifespan Extension by Dietary Deprivation in C. elegans.” (Co-PI).
2006-2007		The NIA Intramural Competitive Grant for the Inter-Laboratory Collaboration for the proposal titled “Anti-Aging Effects of Cranberry Supplementation in Rats.” (Co-PI).
2006-2007		The Ellison Medical Foundation Award for the proposal titled “Developing a Large-Scale Fly Resource to Screen Aging Interventions” (as the Collaborator Investigator).
2005-2006		The Cranberry Institute Award for the proposal titled “Anti-aging Effects of Cranberry: A Cross-species Study”.
2005-2006		The NIA Intramural Competitive Grant for the Inter-Laboratory Collaboration for the proposal titled “Defining germline functions of the longevity-control FOXO genes in C. elegans, Drosophila and mice.” (Co-PI).
Invited Talks
2009		Cranberry Health Research Conference, Savannah, GA.
2009		The Asia-Pacific Congress of Entomology 6th Annual Conference, Beijing, P. R. China (as aCo-Chair of the Genomics Session).
2009		Institute of Zoology, Chinese Academy of Sciences, Beijing, P. R. China.
2009		Department of Neurology, Nafang Hospital, Guangzhou, P. R. China.
2009		Department of Biochemistry, Chang Gung University, Taiwan.
2009		Department of Pathology, Nagasaki University, Nagashaki, Japan.
2009		The Annual Meeting of the Japan Society for Biomedical Gerontology, Yokohama, Japan.
2008		Center for Integrated Biosystems, Utah State University, Logan, UT.
2007		The Gerontological Society of America 60th Annual Scientific Meeting, San Francisco, CA.
2007		The American Aging Association 36th Annual Meeting, San Antonio, TX.
2006		Cranberry Health Research Conference, Charleston, SC.
2006		Department of Biology, University of Texas, San Antonio, TX.
2006		Molecular and Cell Biology Program, University of Maryland, College Park, MD.
2004		Neuroscience Interest Group, National Institutes of Health, Bethesda, MD.
2004		Department of Animal Sciences, University of Maryland, College Park, MD.
Other Academic Activities
2010-Present		Member of the Editorial Board for the Journal of Gerontology: Biological Sciences.
2009-Present		Member of the Laboratory Specialist Promotion Committee at the NIA.
2009-Present		Member of Associate Editors for the Frontiers in Aging Neuroscience.
2009		Member of the National Scientific Advisory Council for the American Federation for Aging Research.
2008-Present		Member of the Editorial Board for the AGE.
2007-Present		Member of the Editorial Board for the Open Longevity Science.
2008		Reviewer in a NIH study section for Postdoctoral Fellowship.
2008		Ad hoc Reviewer for the Research into Ageing Foundation.
2008		Ad hoc Reviewer for Human Frontier Science Program Fellowship.
2008		Ad hoc Reviewer for Israel Science Foundation.
2006		Ad hoc Reviewer for NIH extramural grants.
2005-2006		Panelist for the Student Program in the 34th and 35th Annual AGE meeting.
2005		Co-Guest Editor for: AGE, 27 (3).
2004-Present		Ad hoc reviewer for various journals including Aging Research Reviews, Gerontology, Mechanisms of Aging and Development, Neurobiology of Aging, Aging Cell, The Journal of American Aging Association, The American Journal of Physiology, Genome Research, Experimental Gerontology, Journal of Applied Physiology, Journal of Gerontology, Molecular and Cellular Endocrinology, Rejuvenation Research.
Patents held
Retrotransposon and methods. United States Patent No. 5,976,795
Mentorship
2006-2010		Thomas Alberico, Postbaccalaureate Fellow. Position after leaving NIA: Medical student at Marshall University, Huntington, West Virginia.
2006-2008		Joy Chang, Postbaccalaureate Fellow. Position after leaving NIA: Medical student at University of Maryland, Baltimore. Maryland.
2007-2008		Jeanne Seeberger, Postbaccalaureate Fellow. Position after leaving NIA: Physician Assistant Program at Philadelphia College of Osteopathic Medicine, Philadelphia, Pennsylvania.
2004-2006		Jason Sinclair, Postbaccalaureate Fellow. Position after leaving NIA: Ph.D. student at the University of Maryland, College Park, Maryland.
2007-2009		Toshimitsu Komatsu, Postdoctoral Fellow. Current Position: Senior Technician, Nagasaki University, Nagasaki, Japan.
2004-2007		Haruyoshi Yamaza, Postdoctoral Fellow. Current position: Assistant Professor, Kyushu University, Fukuoka, Japan.
Publications (Peer-reviewed)
Sun, X.P., Seeberger, J., Alberico, T., Wang, C., Wheeler, C.T., Schauss, A.G. and Zou, S. Açai palm fruit (Euterpe oleracea Mart.) pulp improves survival of flies on a high fat diet. Experimental Gerontology 45(3):243-51, 2010. (PMC2826513) Zou, S. * (Corresponding authors), Carey, J.R., Liedo P., Ingram, D.K., Yu, B. and Ghaedian, R. Prolongevity effects of an oregano and cranberry extract are diet-dependent in the Mexican fruit fly (Anastrepha ludens). Journal of Gerontology Serial A: Biological Sciences.* 65(1):41-50, 2010. (PMC2796885). Zhang, D.M., Jiang, D.P., Yanney, M., Zou, S. and Sygula, A. Ratiometric raman spectroscopy for quantification of protein oxidative damage. Analytical Biochemistry. 391(2):121-6, 2009. (PMC2773654). Zou, S.* (Corresponding authors), Carey, J.R., Liedo P., Ingram, D.K., Müller, H.G., Wang, J.L., Yao, F., Yu, B. and Zhou, A. The prolongevity effect of resveratrol depends on dietary composition and calorie intake in a tephritid fruit fly. Experimental Gerontology* 44: 472-6, 2009. Zhang, W., Zou, S., Song, J. (co-corresponding authors). Term-tissue specific models for prediction of gene ontology biological processes using transcriptional profiles of aging in Drosophila melanogaster. BMC Bioinformatics. 9:129, 2008. (PMC2322984). Zhan, M., Yamaza, H., Sun, Y., Sinclair, J., Li, H., Zou, S.* Temporal and spatial transcriptional profiles of aging in Drosophila melanogaster. Genome Research 17 (8):1236-1243, 2007. (Highlighted in Research Highlights, Genetics: Time waits for no fly. Nature 448, 390-391) (PMC1933522). Zhu, M., Lee, G.D., Ding, L. Hu, J.P., Qiu, G., de Cabo, R., Bernier, M., Ingram, D.K. and Zou, S.: Adipogenic Signaling in rat white adipose tissue: modulation by aging and calorie restriction. Experimental Gerontology 42: 733-744, 2007. (PMC1978194). He, H.J., Pires, R., Zhu, T.N., Zhou, A.H., Gaigalas, A.K., Zou, S.* and Wang, L. * (co-corresponding authors). A Fluorescence resonance energy transfer based method for detection of DNA binding activities of nuclear factor kappaB. Biotechniques* 43: 93-98, 2007. Norgate, M,, Southon, A., Zou, S., Zhan, M., Sun, Y., Batterham, P., Camakaris, J. Copper homeostasis gene discovery in Drosophila melanogaster. Biometals 20(3-4):683-697, 2007. Zou, S., Sinclair, J. (Co-first author), Wilson, M.A., Carey, J.R., Liedo, P., Oropeza, A., Kalra, A., de Cabo, R., Ingram, D.K., Longo, D.L., Wolkow, C.A. Comparative approaches to facilitate the discovery of prolongevity interventions: Effects of tocopherols on lifespan of three invertebrate species. Mechanisms of Ageing and Development* 128:222-6, 2007. (PMC1820625). Lee, G.D., Wilson, M.A. Zhu, M., Wolkow, C.A. de Cabo, R., Ingram, D.K. and Zou, S.: Dietary deprivation extends lifespan in Caenorhabditis elegans. Aging Cell 5: 515-24, 2006. (PMC2546582). Ingram, D.K., Roth, G.S., Lane, M.A., Ottinger, M.A., Zou, S., de Cabo, R. and Mattison, J.: The potential for dietary restriction to increase longevity in humans: extrapolation from monkey studies. Biogerontology 7 (3): 143-148, 2006. Ingram, D.K., Zhu, M., Mamczarz, J., Zou, S., Mark A Lane, M.A., Roth, G.S. and de Cabo, R.: Calorie restriction mimetics: an emerging research field. Aging Cell 5(2): 97-108, 2006. McCarroll, S. A., Murphy, C. T., Zou, S., Pletcher, S. D., Chin, C. S., Jan, Y. N., Kenyon, C., Bargmann, C. I. and Hao, L.: Comparing genomic expression patterns across species identifies shares transcriptional profile in aging. Nature Genetics 36: 197-204, 2004. Zou, S., Meadows, S., Sharp, L., Jan, L.Y. and Jan, Y.N.: Genome-wide study of aging and oxidative stress response in Drosophila melanogaster. Proceedings of the National Academy of Sciences, U.S.A. 97: 13726-31, 2000. Zhu, Y.; Zou, S.** (Co-first author), Wright, D.A. and Voytas, D.F.: Tagging chromatin with retrotransposons: target specificity of the Saccharomyces* Ty5 retrotransposon changes with the chromosomal localization of Sir3p and Sir4p. Genes & Development 13: 2738-49, 1999. Zou, S. and Voytas, D.F.: Silent chromatin determines integration preference of Saccharomyces retrotransposon Ty5. Proceedings of the National Academy of Sciences, U.S.A. 94: 7412-6, 1997. Zou, S., Kim, J.M. and Voytas, D.F.: The Saccharomyces retrotransposon Ty5 influences the organization of chromosome ends. Nucleic Acids Research 24: 4825-31, 1996. Zou, S., Ke, N., Kim, J.M. and Voytas, D.F.: The Saccharomyces retrotransposon Ty5 integrates preferentially into regions of silent chromatin at the telomeres and mating loci. Genes & Development 10: 634-45, 1996. (Cover Article). Zou, S., Wright, D.A. and Voytas, D.F.: The Saccharomyces Ty5 retrotransposon family is associated with origin of DNA replication at the telomeres and the silent mating locus HMR. Proceedings of the National Academy of Sciences, U.S.A. 92: 920-4, 1995.
Invited Reviews and Book Chapters
21. Poirier, L., de Cabo, R. and Zou, S. Dietary restriction and aging in Drosophila melanogasterBook Chapter in Calorie Restriction, Aging and Longevity. Edited by Arthur V. Everitt. 2010. 22. Zou, S., and Wolkow, C.A.: Invertebrate models for studying human aging. AGE 27: iii-iv, 2005. 23. Dong, Y. and Zou, S. Sirtuins and aging. (in “Epigenetics of Aging” edited by Dr. Trygve Tollefsbol.). 2009 (peer-reviewed book chapter). 24. Allard, J.S., Perez, E, Zou, S. and de Cabo, R.: Dietary activators of Sirt1. Molecular and Cellular Endocrinology 299:58-63, 2009. (PMC2727669). 25. Wolkow, C.A., Zou, S., Mattson, M.P.: Aging of the nervous system. Book Chapter in Comparative Biology of Aging. Edited by Norm Wolf. 2009 (in press). 26. Zou, S., He, H.J., Zong, Y., Shi, L. and Wang, L. DNA microarrrays: Applications, future trends, and need for standardization, Book Chapter, Part C8 in Standardization and Quality Assurance in Fluorescence Measurements II, Springer Inc., New York, NY. (2008). 27. Carey, J.R., Zou, S. Theories of life span and aging. Book Chapter 5 in The Physiological Basis of Aging and Geriatrics, 4th edition, CRC Press, Boca Raton, FL. (2007).
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