National Institute on Aging National Institutes of Health

NIA Home Research Programs Intramural

Sige Zou, Ph.D., Investigator Functional Genomics Unit Laboratory of Experimental Gerontology E-mail: zous@mail.nih.gov

Education

1992-1996 Ph.D., Iowa State University, Ames, Iowa Programs of Molecular, Cellular and Developmental Biology Mentor: Dr. Daniel F. Voytas Dissertation: Integration preference of the retrovirus-like transposable element Ty5 of Saccharomyces.

1986-1990 B.S., Fudan University, Shanghai, P.R. China Department of Genetics and Genetic Engineering Major: Genetics and Genetic Engineering

Brief Chronology of Employment

2004-Present Investigator, National Institute on Aging, Baltimore, Maryland Research: Aging and Aging Intervention in Drosophila melanogaster

2003-2004 Senior Scientist, Bio-Rad Laboratories, Hercules, California Projects: R & D on instruments and reagents for microarray applications

1997-2003 Postdoctoral Fellow, University of California at San Francisco Supervisor: Dr. Yuh-Nung Jan Research: Aging in Drosophila melanogaster

1994 Teaching Assistant for Genetics 520L, Iowa State University, Ames, Iowa

1990-1992 Technician, Fruit Development Corporation of Dongguan Dongguan, Guangdong Province, P.R. China

Honors and Other Special Scientific Recognition

1997-2000 Damon Runyon-Walter Winchell Cancer Research Award

1996 Research Excellence Award, Iowa State University

1995 MCDB Competitive Research Fellowship, Iowa State University

1987-1988 Fudan Fellowship, Fudan University

Patents held

Retrotransposon and methods. United States Patent No. 5,976,795 Inventors: Voytas, D.F. and Zou, S.

Present Address

Laboratory of Experimental Gerontology National Institute on Aging 5600 Nathan Shock Drive Baltimore, MD 21224-6825 Phone: 410-558-8461 Fax: 410-558-8450 E-mail: zous@mail.nih.gov

Bibliography

Ingram, D.K., Roth, G.S., Lane, M.A., Ottinger, M.A., Zou, S., de Cabo, R., Mattison, J.A. (2006): The potential for dietary restriction to increase longevity in humans: extrapolation from monkey studies. Biogerontology [Epub ahead of print]. Ingram, D.K., Zhu, M., Mamczarz, J., Zou, S., Lane, M.A., Roth, G.S., de Cabo, R. (2006): Calorie restriction mimetics: an emerging research field. Aging Cell 5(2): 97-108. McCarroll, S. A., Murphy, C. T., Zou, S, Pletcher, S. D., Chin, C. S., Jan, Y. N., Kenyon, C., Bargmann, C. I., Hao, L. (2004): Comparing genomic expression patterns across species identifies shares transcriptional profile in aging. Nature Genetics 36: 197-204. Zou, S. Meadows, S., Sharp, L., Jan, L.Y. and Jan, Y.N. (2000): Genome-wide study of aging and oxidative stress response in Drosophila melanogaster. Proceedings of the National Academy of Sciences, USA 97: 13726-13731. Zhu, Y.*; Zou, S.* (*Co-first author); Wright, D.A, Voytas, D.F. (1999): Tagging chromatin with retrotransposons: target specificity of the Saccharomyces Ty5 retrotransposon changes with the chromosomal localization of Sir3p and Sir4p. Genes & Development 13: 2738-2749. Zou, S. and Voytas, D.F. (1997): Silent chromatin determines integration preference of Saccharomyces retrotransposon Ty5. Proceedings of the National Academy of Sciences, USA 94: 7412-7416. Zou, S., Kim, J.M., and Voytas, D.F. (1996): The Saccharomyces retrotransposon Ty5 influences the organization of chromosome ends. Nucleic Acids Research 24: 4825-4831. Zou, S., Ke, N., Kim, J.M., and Voytas, D.F. (1996): The Saccharomyces retrotransposon Ty5 integrates preferentially into regions of silent chromatin at the telomeres and mating loci. Genes & Development 10: 634-645. (Cover Article). Zou, S., Wright, D.A. and Voytas, D.F. (1995): The Saccharomyces Ty5 retrotransposon family is associated with origin of DNA replication at the telomeres and the silent mating locus HMR. Proceedings of the National Academy of Sciences, USA 92: 920-924.

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