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Research Programs
Intramural

Rafael de Cabo, Ph.D. Rafael de Cabo, Ph.D., Senior Investigator
Mechanisms and Interventions of Aging Section
Laboratory of Experimental Gerontology

E-mail: deCaboRa@mail.nih.gov
Education

Sept 1988 – Sept 1993            BS- and MS-equivalent in Cellular and Molecular Biology (“Licenciado en Ciencias Biológicas”) Cordoba University, Córdoba, Spain
Aug 1994 –Mar 2000              Ph.D., Nutrition, Purdue University, West Lafayette, IN

Scientific Training
Sept 1988 – Sept 1993            Proctor and Research Assistant, Department of Cell Biology and Histology, Córdoba University, SPAIN
Oct 1993 – Aug 1994              Visiting Research Scholar, Department of Medicinal Chemistry and   Pharmacognosy, Purdue University, West Lafayette, IN
Aug 1994 – Mar 2000             Graduate Student, Department of Foods and Nutrition, Purdue University, West Lafayette, IN

Apr 2000 – Sept 2004             Postdoctoral Fellow, Intramural Research Training Award, Laboratory of Neurosciences, NIA, NIH, Baltimore, MD

Positions
Oct 2004 – March 2009          Tenure Track Investigator, Laboratory of Experimental Gerontology, NIA, NIH, Baltimore, MD

March 2009 – Present             Senior Investigator, Laboratory of Experimental Gerontology, NIA, NIH, Baltimore, MD

Honors and Awards
2010                                       Fellow of the Gerontological Society of America
2006                                       Elected Member of the Board of Directors, American Aging Association (4 year term)
2006                                       Nathan Shock New Investigator Award of the Gerontological Society of America
2005                                       CERA (The Centre for Education and Research on Ageing) Visiting professor, University of Sydney and Concord Hospital, Sydney, Australia, 2006
2004-present                          Awards for Research Excellence and travel awards to conferences to laboratory members each year by different organizations (American Aging Association, FASEB and Fellows Award for Research Excellence (NIH))
2004                                      Young Scientist Award presented at the 26th conference of the Shock Society
2003                                      Paul E. Glenn Runner-Up Award for Meritorious Research from The American Aging Association
2001                                      Paul E. Glenn Award for Meritorious Research from The American Aging Association

Grant panels

Sept 2005                             Genesis Oncology Trust, New Zealand
Jan 2007 – Present                Spanish Ministry of Science and Education. Fisiologia y Farmacologia en la Agencia Nacional de Evaluación y Prospectiva (“ANEP”)
Jan 2008 – Present                American Federation for Aging Research and Ellison Medical Foundation
July 2008                              National Science Foundation, USA
July 2008                              Biotechnology and Biological Sciences Research Council, UK
Grants and Research Support

National Institute on Aging, NIH Intramural Research Program, 2004-Present

Regulación de la biosíntesis del coenzima Q en eucariontes, Universidad Pablo de Olavide (BMC2002-01602). PI: Plácido Navas Lloret, 2003-2005 (No direct funding associated with the grant to AMNU)

Role of quinone reductase activity in the control of proliferation and senescence in animal cells, Universidad de Córdoba. PI: José Manuel Villalba, 2006-2010 (No direct funding associated with the grant to AMNU)

Exercise and Calorie Restriction Mimetics on Biomarkers of Health and Longevity, NIA Intramural funding for Interlaboratory Collaboration, PI, 2006-2007

Resveratrol’s Effect on Diet-Induced Obesity in Rhesus Macaques, NIA Intramural funding for Interlaboratory Collaboration, co-PI, 2006-2008

Modulation of Aging Processes by the Plasma Membrane Redox System (PMRS), NIA Intramural funding for Interlaboratory Collaboration, PI, 2006-2008

Influence of HuR and HuR-Regulated SIRT1 on Melanoma, NIA Intramural funding for Interlaboratory Collaboration, co-PI, 2005-2006

Consequences of Modulating SIRT1 Activity and Expression Levels in a Melanoma Cancer Model, NIA Intramural funding for Interlaboratory Collaboration, co-PI, 2006-2007

Sirtuins and the molecular epidemiology of frailty in older men, University of Sydney and Centre for Education and Research on Ageing (NHMRC). PI: Robert Cumming, 2007-2011 (No direct funding associated with the grant to AMNU)

Dietary restriction, aging and the proteosome, NIH RO1. University of Kentucky. PI: Jeffrey Keller, 2005-2009 (No direct funding associated with the grant to AMNU)

Caloric restriction, ageing and the liver sinusoidal endothelium, University of Sydney and Centre for Education and Research on Ageing (NHMRC 464833). PI: David LeCouteur, 2006-2010 (No direct funding associated with the grant to AMNU)

The effect of maternal diet supplementation with blueberries on outcomes from hypoxic-ischemic injury in rat pups. High Bush Blueberry Council. NIA and Johns Hopkins University. PI: Rafael de Cabo, Anne Burke and Cynthia Holcroft, 2005-2006

Effects of trans-resveratrol on diet induced obesity in non-human primates, Office of Dietary Supplements, NIH. PI: Kevin Pearson, Rafael de Cabo, Julie Mattison, 2009-201

Editorial Boards
Nov 2007 - Present . Aging Cell
Oct 2008 – Present. AGE
Jan 2010 – Present. Editor in Chief, Journal of Gerontology Biological Sciences
Jan 2010 – Present. BBA-Molecular Mechanisms of Disease
Journal Reviewer
Ageing Research Reviews, Aging Cell, Bioscience Reports, BMC Neuroscience, Brain Research, Cell, Experimental Aging Research, Experimental Biology and Medicine, Experimental Gerontology, Free Radicals in Biology and Medicine, Gerontology, Journal of Anti-Aging Medicine, Journal of Biological Chemistry, Journal of Cell Science, Journal of Gerontology, Journal of Cellular and Molecular Medicine, Journal of Neurochemistry, Journal of Neuroscience Methods, Journal of the American Aging Association, Mechanisms of Ageing and Development, Nature, Nature Comunications, Neurobiology of Aging, New England Journal of Medicine, PLoS Biology, PLoS Medicine, PLoS One, Proceedings of the National Academy of Science, Science, Nutrition
Meeting Organization
First International Meeting on Aging June 2008, University of Sao Paulo at Araras, Brazil
Vice-Chair of the 2009 Gordon Conference on the Biology of Aging
Co-Chair of the 2010 Gordon Conference on the Biology of Aging
Co-Chair of the 2010 International Workshop on Future Perspectives on Aging Research, Seville, Spain
Teaching Experience
Aug 1994 – April 2000 Teaching Assistant, Department of Foods and Nutrition Purdue University, West Lafayette, IN
Aug 2000 – May 2004 Invited Lecturer, Physiology of Aging Graduate Course College of Notre Dame of Maryland, Baltimore, MD
Jan 2001 – Oct 2003 Invited Lecturer to Graduate Course, “Análisis Experimental en Biología”
Oct 2003 – Present Lecturer, Department of Environmental Sciences, Area of Cell Biology, Graduate course “Subcellular fractionation and characterization methods”. Universidad Pablo de Olavide, Sevilla, Spain
Oct 2008 – Present Lecturer, Department of Cell Biology and Biochemistry, Area of Cell Biology, Graduate course “Nutrition and Aging”. Universidad de Cordoba, Cordoba, Spain
Mentorship
Michelle Rios, Student IRTA (2000-02) NMPU, Laboratory of Neurosciences.
          CURRENT POSITION: Microbiologist. Infection Control Devices Branch. FDA
Maria Jimenez, Student (2001-02) NMPU, Laboratory of Neurosciences.
          CURRENT POSITION: Postdoctoral Fellow, Universidad de Sevilla
Demetrio Sierra, Student IRTA (2004-05) AMNU, Laboratory of Experimental Gerontology
          CURRENT POSITION: Graduate School, U Puerto Rico
Bruce Jones, Student IRTA (2004-05) AMNU, Laboratory of Experimental Gerontology
          CURRENT POSITION: Graduate School, Cambridge, UK
Kara Duffy, Student/technical IRTA (2001-05) AMNU, Laboratory of Experimental Gerontology
          CURRENT POSITION: Graduate School, U. of Maryland
Sarah Hilmer, M.D. Ph.D. Visiting Fellow (2004-05) AMNU, Laboratory of Experimental Gerontology
          CURRENT POSITION:Assistant Profesor, U. Sydney, Australia
Hamish Jamieson, M.D. Visiting Fellow (2006) AMNU, Laboratory of Experimental Gerontology
          CURRENT POSITION: Geriatrics Med. Resident, U. Sydney
Marta Montori Grau, Student (2006) AMNU, Laboratory of Experimental Gerontology
          CURRENT POSITION: Graduate Student, U. Barcelona
Stuart Músala, Student IRTA (2005) AMNU, Laboratory of Experimental Gerontology
          CURRENT POSITION: Medical School, Drexler U
Nathan Price, Student IRTA (2005-06) AMNU, Laboratory of Experimental Gerontology
          CURRENT POSITION: Graduate School, Harvard U.
Avash Kalra, Student IRTA (2005-06) AMNU, Laboratory of Experimental Gerontology
          CURRENT POSITION: Boonshoft School of Medicine, Wright State University, Dayton, OH
Scott Emerson, Student IRTA (2005) AMNU, Laboratory of Experimental Gerontology
          CURRENT POSITION: Medical School. Baylor University.
Joe Hernandez , Student IRTA (2005) AMNU, Laboratory of Experimental Gerontology
          CURRENT POSITION: Medical School, University of California San Francisco
Nicole Hunt, Postdoctoral IRTA (2005-2007) AMNU, Laboratory of Experimental Gerontology
          CURRENT POSITION: Applying for faculty positions in Alabama/Louisiana
Dong-Hoon Hyun, Postdoctoral IRTA (2004-2007) AMNU, Laboratory of Experimental Gerontology and Laboratory of Neurosciences
          CURRENT POSITION: Assistant Professor, Ewha Womans University, Seul, Korea
Carolina Smith, Contractor (2006-2007) AMNU, Laboratory of Experimental Gerontology
          CURRENT POSITION: Program assistant at NIDA
Arelys Ramos, Student IRTA (2006-2007) AMNU, Laboratory of Experimental Gerontology
          CURRENT POSITION: Medical School, University of Puerto Rico
Davida Kamara, Student IRTA (2006-2007) AMNU, Laboratory of Experimental Gerontology
          CURRENT POSITION: Research Assistant at Dupont
Cristina Fernandez, Visiting Student (2007) AMNU, Laboratory of Experimental Gerontology
          CURRENT POSITION: Graduate Student, University of Cordoba
Maria Cascajo Almenara, Visiting Student (2007) AMNU, Laboratory of Experimental Gerontology
          CURRENT POSITION: Graduate Student, Universidad Pablo de Olavide
Lijuan Liu, Contractor (2004-2007) AMNU, Laboratory of Experimental Gerontology
          CURRENT POSITION: Biologist, Johns Hopkins University
Joe Baur, Visiting fellow (2005-08) AMNU, Laboratory of Experimental Gerontology
          CURRENT POSITION: Assistant Professor at University of Pennsylvania
Silvia Mata, Visiting Student (2008) AMNU, Laboratory of Experimental Gerontology
          CURRENT POSITION: Graduate Student, University of Barcelona
Evi Marie Mercken, Visiting Student (2008) AMNU, Laboratory of Experimental Gerontology
          CURRENT POSITION: Postdoctoral Fellow, University of Maastritch and AMNU
Kevin Pearson, Postdoctoral Fellow (2005-09) AMNU, Laboratory of Experimental Gerontology
          CURRENT POSITION: Assistant Professor, University of Kentucky
Joanne Allard, Postdoctoral Fellow (2004-2010) AMNU, Laboratory of Experimental Gerontology
           CURRENT POSITION: Assistant Professor, Howard University (Starting spring 2010)
Professional and Academic Activities
President, Department of Foods and Nutrition Graduate Students Committee (1996 – 2000)
Senator, Purdue University Student Government (1997 – 1998)
Chair of the Student Chapter Committee of the American Aging Association
Organizer of the Calorie Restriction Interest Group at NIA
Representative for the Biological Sciences Section to the GSA Membership Committee
Co-Chair for the Program Committee of the Gerontological Society of America
NIH Citizenship and Related Activities
Organizer of the Eos and Tithonus (aging research interest group)
NIA Tenure Track Representative at NIH
Search Committee for Tenure Track Investigator for LNS
Search Committee for Staff Scientist for LPC
Search Committee for Tenure Track Investigator for LEG
Search Committee for Staff Scientist for LNG
CRADA
SIRTRIS pharmaceuticals. Effects on health and longevity of C57BL/6J mice of novel sirtuin activators 2007-2014.
Societies
American Society for Cell Biology
American Aging Association
Gerontological Society of America
American Association for the Advancement of Science
Invited Lectures
  1. de Cabo, R. Gonzalez-Reyes, J.A. and Navas, P. Ascorbate free radical facilitates G0 ® G1 transition in onion roots quiescent cells. Biochemical Mechanism Involved in Growth Regulation (BMGR), International Symposium. 1991, Milan, Italy.

  2. Navas. P., de Cabo, R., Navarro, F., Rodriguez-Aguilera, J.C., Gonzalez-Reyes, J.A. and Buron, I. Ascorbate facilitates the transit from quiescent to division in eukaryotic cells. Texas Society for Electron Microscopy. 1991, Clear Lake, TX.

  3. de Cabo, R. An in vitro model of enhanced stress responsiveness by caloric restriction: A novel method for evaluation of possible mechanisms and candidate caloric restriction mimetics. American Aging Association. June 2001. Madison, WI.

  4. de Cabo, R. An in vitro model to study caloric restriction. Universidad Pablo de Olavide, Sevilla. October 2001, Sevilla, Spain.

  5. de Cabo, R. Age and calorie restriction effects on C57BL/6 liver plasma membrane antioxidant redox system. Universidad Pablo de Olavide, Sevilla. February 2002, Sevilla, Spain.

  6. de Cabo, R. 2002 Plasma Membrane Redox System During Aging and Caloric Restriction. American Aging Association. 2002, San Diego, CA.

  7. de Cabo, R.  Plasma membrane redox system: possible role on the underlying mechanisms of calorie restriction. Current Perspectives on the Mechanisms of Caloric Restriction. 2002, Bandera TX.

  8. de Cabo, R.  Aging and calorie restriction: effects on intraperitoneal macrophages. 2002, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD.

  9. de Cabo, R.  The plasma membrane redox system during aging and calorie restriction. Workshop on Molecular Biology and Function of Plasma Membrane Redox, UCLA, USA, March 2004, Los Angeles, CA.

  10. de Cabo, R. Development and characterization of a novel in vitro model to study caloric restriction. Universidad Nacional de Colombia. September 2003, Bogotá, Colombia.

  11. de Cabo, R. Is the messenger for the cytoprotective effects of calorie restriction in the blood? Gerontology Society of America, San Diego, CA. November 2004, San Diego, CA.

  12. de Cabo, R.  Eat less, live longer. Department of Pediatrics, University of Maryland, School of Medicine. March 2004, Baltimore, MD.

  13. de Cabo, R.  New insights on mechanisms of calorie restriction: An in vitro model and the plasma membrane redox system. Department of Animal and Avian Sciences. University of Maryland. October 2004, College Park, MD.
  14. de Cabo, R.  Eat less, live longer: Caloric restriction and aging. Depts. of Biol. Sciences and Chemistry. Goucher College. November 2004, Baltimore, MD.

  15. de Cabo, R.  Calorie restriction and aging alter rat liver plasma membrane antioxidant system. Marion Bessin Liver Research Center. Albert Einstein College of Medicine. November 2004, New York, NY.

  16. de Cabo, R.  Biology of Aging Lecture. Dept. of Biological Sciences. Johns Hopkins University. April 2005, Baltimore, MD.

  17. de Cabo, R. Calorie restriction and aging alter rat liver plasma membrane antioxidant system. University of Kentucky Sanders Brown Center on Aging. May 2005, Lexington, KY.

  18. de Cabo, R.  New insights on mechanisms of calorie restriction: An in vitro model and the plasma membrane redox system.  University of Washington. May 2005, Seattle, WA.

  19. de Cabo, R.  Biology of Aging Lecture. ANZAC center. November 2005, Sidney, Australia.

  20. de Cabo, R.  New insights on mechanisms of calorie restriction: An in vitro model and the plasma membrane redox system. Concord Hospital. November 2005, Concord, Sydney, Australia.

  21. de Cabo, R.  Biology of aging and calorie restriction lecture. Oxford Hospital. November 2005, Oxford, Sidney, Australia.

  22. de Cabo, R.  More and better mitochondria: A key anti-aging mechanism of caloric restriction. Department of Biotechnology. University of Natural Resources and Applied Life Sciences. November, 2005 Vienna, Austria.

  23. de Cabo, R.  Mechanisms of calorie restriction: an in vitro model and the plasma membrane redox system. Institute for Biomedical Aging Research of the Austrian Academy of Sciences. November 2005, Innsbruck, Austria.

  24. de Cabo, R.  Biology of aging and calorie restriction lecture. The Johns Hopkins University Department of Psychological and Brain Sciences. May 2006, Baltimore, MD.

  25. de Cabo, R.  Effects of Resveratrol in mice on a high calorie diet. The Johns Hopkins University Department of Biology. June 2006, Baltimore, MD.

  26. de Cabo, R.  Effects of Resveratrol in mice on a high calorie diet. Novartis. January 2007, Boston, MA.

  27. de Cabo, R.  Lifespan extension by Resveratrol. January 2007, Verbier, Switzerland.

  28. de Cabo, R.  In Vino Veritas, Manipulando el Envejecimiento y la Longevidad. Universidad de Cordoba. March 2007, Córdoba, Spain.

  29. de Cabo, R.  Lifespan extension by Resveratrol. AGE meeting. June 2007, San Antonio, TX.

  30. de Cabo, R.  Aging and calorie restriction: effects on intraperitoneal macrophages. FASEB Summer conference. July 2007, Tucson, AZ.

  31. de Cabo, R.  Lifespan extension by Resveratrol. Gordon Conference on the Biology of Aging. September 2007, Les Diablerets, Switzerland.

  32. de Cabo, R.  Lifespan Extension by Resveratrol, a Toast to Longevity? University of Maryland School of Medicine. February 2008, Baltimore, MD.

  33. de Cabo, R.  Lifespan Extension by Resveratrol, a Toast to Longevity? Oregon National Primate Research Center. Oregon Health Science University. April 2008, Portland, OR.

  34. de Cabo, R.  Calorie Restriction in Aging Research: Where Have We Been and Where Are We Going? October 2008, Bandera, San Antonio, TX.

  35. de Cabo, R. Lifespan extension by Resveratrol. November 2008, Phoenix, AZ.

  36. de Cabo. R. Interventions for Healthy Aging. Gerontological Society of America. November 2008, Washington DC.

  37. de Cabo. R. Lifespan Extension by Resveratrol, a Toast to Longevity? University of Maastricht, Netherlands. February 2009, Netherlands.

  38. de Cabo. R. Interventions for Healthy Aging and Longevity: Is There a Fountain of Youth? University of Washington at Saint Louis. March 2009, Saint Louis, MO.

  39. de Cabo. R. Interventions for Healthy Aging and Longevity: Is There a Fountain of Youth? Pennington Research Center. April, 2009, Baton Rouge, LA.

  40. de Cabo. R. Nrf2 mediates cancer protection but not pro-longevity induced by caloric restriction. November 2009, Madrid, Spain.

  41. de Cabo. R. Nrf2 mediates cancer protection but not pro-longevity induced by caloric restriction. November 2009, Washington DC.

  42. de Cabo. R. Pharmacological Interventions for Healthy Aging and Longevity: Is There a Fountain of Youth? November 2009, Florence, Italy.

  43. de Cabo. R. Pharmacological Interventions for the Improvement of Health and Longevity. International Workshop on Future Perspectives on Aging Research, Seville, Spain

  44. de Cabo. R. Interventions for Healthy Aging; Resveratrol and other SIRT1 activating compounds. Forum on the Basic Biology of Aging. March 2010. Cordoba, Spain.

  45. de Cabo. R. Resveratrol and Longevity; Controversies. Meeting on Controversies on Aging and Longevity. June 2010, Barcelona, Spain.

  46. de Cabo. R. Resveratrol induces health and lifespan extension in C57Bl6 mice. Seminar Series CSIC. June 2010, Barcelona, Spain.

  47. de Cabo. R. Calorie Restriction: Is It All About Appetite? Internatioanl Conference on Neuroendocrinology of aging, August 2010. Bregenz, Austria.

  48. de Cabo. R. Resveratrol, from mice to monkeys. August 2010. Basel, Switzerland.

  49. de Cabo. R. Metabolic Interventions for Healthy Aging. Activating SIRT1. Cold Spring Harbor Meeting on Molecular Genetics of Aging. September 2010. Cold Spring Harbor Laboratories, New York.

  50. de Cabo. R. SRT1720 induces Healthy Aging and Longevity in Mice on a High fat diet. October 2010, Palermo, Italy.

  51. de Cabo R. Pharnacological Interventions for Healthy Aging and Longevity: Resveratrol and SRT1720. Gerontological Society of America, November 2010. New Orleans

  52. de Cabo. R. Calorie Restriction induces Nrf2 and mediates cancer protection but not pro-longevity induced by caloric restriction. Ninth Annual International Conference on Frontiers in Cancer Prevention Research. November 2010, Philadelphia

  53. de Cabo. R. Calorie Restriction and Aging; an update. 52nd American Society of Hematology meeting. December 2010, Orlando, Florida.
Plenary and Named Lectures
    1. de Cabo, R.  Calorie restriction and aging alter rat liver plasma membrane antioxidant system. CERA. November 2005, Sidney, Australia.

    2. de Cabo, R. New insights into mechanisms of Calorie restriction. Gerontological Society of America. Nathan Shock New Investigator Award Lecture. 2006, Dallas, TX.

    3. de Cabo, R. Calorie restriction and exercise. FEMEDE. October 2007, Sevilla, Spain.

    4. de Cabo. R. Interventions for Healthy Aging and Longevity: Is There a Fountain of Youth? NIH Director Seminar Series. January 2009. NIH, Washington D.C.

    5. de Cabo. R. Lifespan Extension by Resveratrol, a Toast to Longevity? SENBA (Spanish Society for Basic and Applied Nutrition). March 2009. Cordoba, Spain.

    6. de Cabo. R. Healthspan Extension by Resveratrol from Mice to Monkeys. World Health Forum at the Italian Embassy. October 2010. Washington D.C.

    7. de Cabo, R. New insights into mechanisms of Calorie restriction. Second Bi-national conference on aging. Santiago de Chile, December 2010. Chile.
Reviews and Book Chapters
    1. Lane, M. A., de Cabo, R., Mattison, J., Anson, R. M., Roth, G. S.  and Ingram, D. K. The Roy Walford legacy: Diet restriction from molecules to mice to monkeys to man and onto mimetics. Exp Gerontol. 2004, 39(6):897-902.

    2. Ingram, D.K., Anson, R.M., de Cabo, R., Mattison, J., Mamczarz, J., Zhu, M., Lane, M. A. and Roth, G. S. Development of calorie restriction mimetics as a prolongevity strategy.  Ann N Y Acad Sci. 2004, 1019:412-423.

    3. Anson, R.M., Jones, B. and de Cabo, R. The diet restriction paradigm: A brief review of the effects of every- other- day feeding. AGE. 2005, 27(1): 17-25.

    4. Navas, P., and de Cabo R. Plasma membrane and aging. Guest editorial. AGE. 2005, 27 (2): 127.

    5. Ingram, D.K., Zhu, M., Mamczarz, J., Zou, S., Lane, M.A., Roth, G.S. and de Cabo, R. Calorie restriction mimetics: an emerging research field. Aging Cell. 2006, 5(2):97-108. [PubMed ID: 16626389].

    6. Hyun, D.H., Hernandez, J.O., Mattson, M.P. and de Cabo, R. The plasma membrane redox system in aging. Aging Research Rev. 2006, 5: 209-220. [PubMed ID: 16697277].

    7. Hunt, N., Hyun, D.H., Allard, J., Minor, R., Ingram, D.K. and de Cabo, R. Bioenergetics of aging and caloric restriction. Aging Research Rev. 2006, 5:125-143. [PubMed ID: 16644290].

    8. Ingram, D. K., Roth, G.S., Lane, M. A., Ottinger, M.A., Zuo, S., de Cabo, R., and Mattison, J. The potential for diet restriction to increase longevity in humans: extrapolation from monkey studies. Biogerontology, 2006, 7(3):143-8. [PubMed ID: 16732404].

    9. Minor, R.K., Smith, C.I., de Cabo, R., Ingram, D.K. Food for life: Maximizing lifespan through the diet Agro Food Industry Hi-Tech. 2007, 18 (1): 36-39.

    10. Le Couteur, D.G., Warren, A., Cogger, V.C., Smedsrød, B., Sorensen, K.K., de Cabo, R., Fraser, R. and McCuskey, R.S. Old age and the hepatic sinusoid. Anat Rec (Hoboken). 2008, 291(6):672-83. [PubMed ID: 18484614].

    11. Navas, P., Villalba, J.M., and de Cabo, R. The importance of plasma membrane coenzyme Q in aging and stress responses. Mitochondrion. 2007 Suppl 1:S34-40. [PubMed ID: 17482527].

    12. Lluch, G.L., Irusta, P.M., Navas, P, de Cabo, R. Mitochondrial biogenesis and healthy aging.  Exp Gerontol. 2008, 43(9):813-9. [PubMed ID: 18662766].

    13. Gorospe, M., and de Cabo, R. AsSIRTing the DNA damage response. Trends Cell Biol. 2008, 18(2):77-83. [PubMed ID: 18215521].

    14. Ungvari, Z., Fernandez-Parrado, C., Csiszar, A., and de Cabo, R. Mechanisms underlying caloric restriction and life span regulation: implications for vascular aging. Circ Res. 2008, 102:519-28. [PubMed ID: 18340017].

    15. Allard, J.S., Perez, E., Zou, S. and de Cabo, R. Dietary activators of Sirt1. Mol Cell Endocrinol. 2009, 299:58-63. [PubMed ID: 19010386].

    16. Minor, R.K., Chang, J.W., and de Cabo, R. Hungry for life: How the arcuate nucleus and neuropeptide Y may play a critical role in mediating the benefits of calorie restriction. Mol Cell Endocrinol. 2009, 299:79-88. [PubMed ID: 19041366].

    17. Minor, R.K., Anson, R.M., de Cabo, R. Calorie restriction and cancer: An update. In: Everitt AV, ed. Calorie Restriction, Aging and Longevity. Springer; 2009 in press.

    18. Spangler, E.L., Long, J., Kelley-Bell, B., Miller, M., Minor, R.K, de Cabo, R. Will calorie restriction stave off age-related brain dysfunction, specifically to learning and memory? A review and critique of the rodent literature. In: Everitt AV, ed. Calorie Restriction, Aging and Longevity. Springer; 2009 in press.

    19. Wei, M., Madia, F., de Cabo, R. and Longo V.D. Aging and Dietary restriction: the Yeast paradigm. In: Everitt AV, ed. Calorie Restriction, Aging and Longevity. Springer; 2009 in press.

    20. Poirier, L., de Cabo, R. and Zou, S.  Dietary Restriction and Aging in Drosophila Melanogaster. In: Everitt AV, ed. Calorie Restriction, Aging and Longevity. Springer; 2009 in press.

    21. Le Couteur, D.G. Sinclair, D.A. Cogger, V., McMahon, A., Warren, A., Everitt, A., Lebel, M and de Cabo, R. The Aging Liver and the Effects of Long Term Caloric Restriction. In: Everitt AV, ed. Calorie Restriction, Aging and Longevity. Springer; 2009 in press.

    22. Csiszar, A., Ungvari, Z., and de Cabo, R. Calorie Restriction and Cardiovascular Disease. In: Everitt AV, ed. Calorie Restriction, Aging and Longevity. Springer; 2009 in press.

    23. Francisco J. Alcaín, F.J., Minor, R.K., Villalba, J.M., and de Cabo, R. Small Molecule Modulators Of Sirtuin Activity. In: Fahy, G.M., ed. The Future of Aging. Springer; 2009 in press.

    24. Ungvari Z, Kaley G, de Cabo R, Sonntag WE, Csiszar A. Mechanisms of vascular aging: new perspectives. J Gerontol A Biol Sci Med Sci. 2010;65(10):1028-41. Epub 2010. Review. PubMed PMID: 20576649; PubMed Central PMCID:PMC2950814.

    25. Martin-Montalvo A, Villalba JM, Navas P, de Cabo R. NRF2, cancer and calorie restriction. Oncogene. 2010 Nov 8. [Epub ahead of print] PubMed PMID: 21057541.

    26. Minor RK, Allard JS, Younts CM, Ward TM, de Cabo R. Dietary interventions to extend life span and health span based on calorie restriction. J Gerontol A Biol Sci Med Sci. 2010;65(7):695-703. Epub 2010 Apr 6. Review. PubMed PMID:20371545; PubMed Central PMCID: PMC2884086.

    27. Ungvari Z, Sonntag WE, de Cabo R, Baur JA, Csiszar A. Mitochondrial Protection by Resveratrol. Exerc Sport Sci Rev. 2011 Apr 19. [Epub ahead of print] PubMed PMID: 21383627.
    28. Mercken EM, de Cabo R. A toast to your health, one drink at a time. Am J Clin Nutr. 2010 Jul;92(1):1-2. Epub 2010 May 26. PubMed PMID: 20504971; PubMed Central PMCID: PMC2884318.
Publications
  1. de Cabo, R. González-Reyes, J.A. and Navas, P. The onset of cell proliferation is stimulated by ascorbate free radical in onion root primordia. Biol. Cell 1993, 77: 232-233.

  2. Morré, D.J., Navas, P., Rodríguez-Aguilera, J.C., Morré, D.M., Villalba, J.M., de Cabo, R. and Lawrence, J. Cyclic AMP plus ATP-dependent modulation of the NADH oxidase activity of porcine liver plasma membranes. Biochim. Biophys. Acta 1994, 1224: 566-574.

  3. Morré, D.J., de Cabo, R., Jacobs, E. and Morré, D.M. Auxin stimulate protein disulfide isomerase from soybean plasma membranes.  Plant Physiol. 1995, 109: 573-578.

  4. Morré, D.J., de Cabo, R., Farley, C., Oberlies, N.H. and McLaughlin, J.L. Mode of action of bullatacin, a potent antitumor acetogenin: Inhibition of NADH oxidase of HeLa and HL-60, but not liver, plasma membranes. Life Sci. 1995, 56(5): 343-348.

  5. Jacobs, E., Morré, D.J., de Cabo, R., Sweeting, M. and Morré, D.M. Response of a protein disulfide isomerase-like activity of transitional endoplasmic reticulum to all-trans retinol. Life Sci.1996, 59(4): 273-284.

  6. de Cabo, R. González-Reyes, J.A. and Navas, P. Root sprouting is synchronized in onions by ascorbate free radical.  J. Plant Growth Regulation, 1996v, 15(2):53-56.

  7. Morré, D.J., Sun, E., Geilen, C., Wu, L-Y., de Cabo, R., Krasagakis, K., Orfanos, C. and Morré, D.M. Capsaicin inhibits plasma membrane NADH oxidase and growth of human and mouse melanoma lines. Eur. J. Cancer, 1996, 32A:1995-2003.

  8. Morré, D.J., Jacobs, E., Sweeting, M., de Cabo, R., and Morré, D.M. A protein disulfide-thiol interchange activity of HeLa plasma membranes inhibited by the antitumor sulfonylurea N-(4-methylphenylsulfonyl)-N’-(chlorophenyl)urea (LY181984). Biochem. Biophys, Acta. 1997, 1325:117-125.

  9. Navarro, F., Navas, P., Burgess, J.R., Bello, R.I. de Cabo, R., Arroyo, A. and Villalba, J. M. Vitamin E and selenium deficiency induces expression of the ubiquinone-dependent antioxidant system at the plasma membrane. FASEB J. 1998, 12:1665-1673.

  10. Navarro, F. Arroyo, A., Martín, S.F., Bello, R.I. de Cabo, R., Burgess, J.R., Navas, P and Villalba, J. M. Protective role of ubiquinone against oxidative stress caused by vitamin E and selenium deficiency. Biofactors, 1999, 9(2-4) 171-177.

  11. Mattes, R.D., Westby, E., de Cabo, R. and Falkner, B. Dietary compliance among salt-sensitive and salt-insensitive normotensive adults. Am. J. Med. Sci, 1999, 315(5): 287-294.

  12. Arroyo, A., Kagan V.E., Tyurin, V.A., Burgess, J.R., de Cabo, R., Navas, P. and Villalba, J.M. NADH and NADPH-dependent reduction of coenzyme Q at the plasma membrane. Antioxid Redox Signal. 2000, 2(2):251-262.

  13. 13. Navas, P., Fernández-Ayala, D.M., Martin, S.F., López-Lluch, G., de Cabo, R., Rodríguez-Aguilera, J.C. and Villalba, J.M. Ceramide-dependent caspase 3-activation is prevented by coenzyme Q from plasma membrane in serum-deprived cells. Free Radic Res. 2002, 36 (4):369-374.

  14. Anson, R.M., Guo, Z., de Cabo, R., Lyun, T., Rios, M., Hagepanos, A., Ingram, D.K., Lane, M. A. and Mattson, M.P. Periodic fasting dissociates beneficial effects of dietary restriction from calorie intake. Proc. Nat. Acad. Sci. 2003, 100:6216-6120.
  15. de Cabo, R., Fürer-Galban, S., Anson, R.M., Gilman, C., Gorospe, M., and Lane, M.A. An in vitro model of caloric restriction. Exp Gerontology. 2003, 38:631-639.
    ****Article featured in Science magazine on-line SAGE-KE and Science, July 9th 2003 (B. S. Kristal, U. Paolucci, Caloric Restriction in trans. Sci SAGE KE 2003).

  16. de Cabo, R., López, G., Cabello, R., Lane, M. and Navas P. Effects of age and Calorie Restriction on the Rat Liver Antioxidant Plasma Membrane Redox System. Exp Gerontol. 2004, 39(3): 297-304.

  17. Cohen, H. Y., Miller, C., Bitterman, K. J., Wall, N. R., Hekking, B., Kessler, B., Gorospe, M.,  de Cabo, R. and Sinclair, D. A. Calorie restriction promotes cell survival by inducing SIRT1. Science. 2004, 305 (5682):390-392.

  18. Zhu, M., Miura, J., Lu, L., Bernier, M., de Cabo, R., Lane, M. A., Roth, G. S. and Ingram, D. K. Circulating adiponectin levels increase in rats on caloric restriction: The potential for insulin sensitization. Exp Gerontology. 2004, 39(7):1049-1059.

  19.  Zhu, M., de Cabo, R., Lane, M. A. and Ingram, D.K. Caloric restriction modulates early events in insulin signaling in liver and skeletal muscle of rat. Ann N Y Acad Sci. 2004, 1019:448-452.
  20. Vega, V., de Cabo, R. and DeMaio, A.  Age and caloric restriction diets are confounding factors that modify the response to LPS by peritoneal macrophages from C57bl/6 mice. Shock. 2004, 22(3):248-253.

  21. Zhu, M., de Cabo, R., Anson, R.M., Ingram, D.K. and Lane, M. A. Caloric restriction modulates early events in insulin signaling in liver and skeletal muscle of rat.  Nutrition. 2005, 21(3): 378-388.

  22. López-Lluch, G., Rios, M., Lane, M.A., Navas, P. and de Cabo, R.  Mouse liver plasma membrane redox system activity is altered by aging and modulated by calorie restriction. AGE 2005, 27(2): 153–160.

  23. López-Lluch, G., Hunt, N., Jones, B., Zhu, M., Jamieson, H., Hilmer, S., Cascajo, M. V.,   Allard, J., Ingram, D.K. and de Cabo, R.  Calorie restriction induces mitochondrial biogenesis and bioenergetic efficiency. Proc. Natl. Acad. Sci. U S A. 2006, 103(6):1768-1773. [PubMed ID: 18662766].
    ****Article featured in Sci. Aging Knowl. Environ., Vol. 2006, Issue 5, p. nw5. [DOI: 10.1126/sageke.2006.5.nw5] Papers of Note.

  24. Bernier, M., Kwon, Y.K., Pandey, S.K., Zhu, T.N., Zhao, R.J., Maciuk, A., He, H.J., de Cabo, R., and Kole, S. Binding of manumycin A inhibits IKB Kinase beta activity. J Biol Chem. 2006, 281(5):2551-2561. [PubMed ID: 16319058].

  25. Liu, D., Chan, S.L., de Souza-Pinto, N.C., Slevin, J., Wersto, R.P., Zhan, M., Mustafa, K., de Cabo, R and Mattson, M.P. Mitochondrial UCP4 mediates an adaptive shift in energy metabolism and increases the resistance of neurons to metabolic and oxidative stress. Neuromol. Med. 2006, 8(3): 389-414s. [PubMed ID: 16775390].

  26. de Cabo, R., Burgess, J.R. and Navas, P. Adapatations to oxidative stress induced by vitamin E deficiency in rat liver. J Bioenerg Biomembr. 2006, 38(5-6):309-17. [PubMed ID: 17033938]

  27. Hyun, D.H., Emerson, S.S., Hunt, N., Mattson, M.P. and de Cabo, R. Up-regulation of plasma membrane-associated redox activities in neuronal cells lacking functional mitochondria. J. Neurochem. 2007, 100(5):1364-74. [PubMed ID: 1725067].

  28. Qin, W., Chachich, M., Lane, M.A., Roth, G., de Cabo, R., Ottinger, M.A., Mattison, J., Ingram, D.K., Gandy, M and Pasinetti, G.M. Calorie restriction attenuates Alzheimer’s disease type brain amyloidosis in Squirrel monkeys (Saimiri sciureus). J Alzheimers Dis 2006, 10(4):417-22. [PubMed ID: 17183154].

  29. Lee, G.D., Wilson, M.A., Zhu, M., Wolkow, C.A., de Cabo, R., Ingram, D.K. and Zou, S. Dietary deprivation extends lifespan in Caenorhabditis elegans. Aging Cell. 2006,5(6):515-24. [PubMed ID: 17096674].

  30. Jamieson, H., Hilmer, S., Cogger, V.C.,   Warren, A., Cheluvappa, R., Abernethy, D. R., Fraser, R., de Cabo R. and Le Couteur , D. G. Caloric restriction dramatically reduces age-related pseudocapillarization of the hepatic sinusoid. Exp. Geron. 2007. 42 (4), 374-378. [PubMed ID: 17204388].

  31. Baur, J.A., Pearson, K. J., Price, N., Jamieson, H. A., Lerin, C.,  Kalra, A., Prabhu, V.V., Allard, J.S., Lopez-Lluch, G., Lewis, K.,  Pistell, P., Poosala, S., Becker, K.G., Boss, O., Gwinn, D., Wang, M., Ramaswamy, S., Fishbein, K.W., Spencer., R.G., Lakatta, E.G., Le Couteur, D., Shaw, R.G., Navas, P., Puigserver, P., Ingram, D.K., de Cabo, R*.,  and Sinclair, D.A*. Resveratrol improves health and increases survival of mice on a high-calorie diet. Nature. 2006, 444(7117):337-42 (*co-senior and co-corresponding authors) [PubMed ID: 17086191].

    *****Selected for the 2006 issue of the Annual Bibliography of Significant Advances in Dietary Supplements Research. http://ods.od.nih.gov/Research/Annual_Bibliographies.aspx
    *****Highlighted at Science’s STKE as a noteworthy contribution to the scientific literature in the “This Week in Signal Transduction” section of the site. http://stke.org

  32. Hyun, D.H., Emerson, S.S., Jo, D. J., Mattson, M.P. and de Cabo, R. Calorie restriction up-regulates the plasma membrane redox system in brain cells and suppresses oxidative stress during aging. Proc. Natl. Acad. Sci. U S A. 2006, 103(52):19908-12. [PubMed ID: 17167053].

  33. Zou, S., Sinclair, J., Wilson, M.A., Carey, J., Liedo, P., Oropeza, A., Kalra, A., de Cabo, R., Ingram, D.K., Longo, D.L. and Wolkow, C.A. Comparative approaches to facilitate the discovery of prolongevity interventions: Effects of tocopherols on lifespan of three invertebrae species. Mech. Ageing Dev. 2007, 128(2):222-6. [PubMed ID: 17804522].

  34. Le Couteur, D.G., Warren, A., Cogger, V.C., Smedsrød, B., Sorensen, K.K., de Cabo, R., Fraser, R. and McCuskey, R.S. Age-related changes in the liver sinusoidal endothelium are a mechanism for dyslipidemia. Ann N Y Acad Sci. 2007, 1114:79-87. [PubMed ID: 18484614].

  35. Duffy, K.B., Spangler, E.L., Devan, B.D., Guo, Z., Bowker, J.L., Janas, A.M., Hagepanos, A., Minor, R.K., de Cabo, R., Mouton, P.R., Shukitt-Hale, B., Joseph, J.A., Ingram, D.K. A blueberry-enriched diet provides cellular protection against oxidative stress and reduces a kainate-induced learning impairment in rats. Neurobiology of Aging 2007 [PubMed ID: 17524525].

  36. Jamieson, H. A., Cogger, V. C., Twigg, S. M., McLennan, S. V., Warren, A., Cheluvappa, R., Hilmer, S.N., Fraser, R.,  de Cabo, R.  and Le Couteur, D.G. Alterations in liver sinusoidal endothelium in a baboon model of type 1 diabetes. Diabetologia 2007, 50(9):1969-76. [PubMed ID: 17604976].

  37. Zhu, M., Lee, G.D., Ding, L., Hu, J., Qiu, G., de Cabo, R., Bernier, M., Ingram, D.K. and Zou, S. Adipogenic signaling in rat white adipose tissue: Modulation by aging and calorie restriction. Exp gerontol. 2007, 42 (8):733-44. [PubMed ID: 17624709].

  38. Yang, H., Yang, T., Norht, B., Baur, J.A., Perez, E., Matsui, T., Carmona, J., Lamming, D.W., Medvedik, O., Maynard, T., Miller, R., Rosenzweig, A., de Cabo, R., Sauve, A. A., and Sinclair, D. A. Nutrient-Sensitive mitochondrial NAD+ levels dictate cell survival. Cell 2007, 130(6):1095-107. [PubMed ID: 17889652].

  39. Pearson, K.J., Lewis, K.N., Price, N.L., Chang, J.W., Perez, E., Cascajo, M.V., Tamashiro,     K.L, Poosala, S., Bell, J.B., Csiszar, A., Ungvari, Z., Kensler, T.W., Yamamoto, Y., Egan, J.M., Longo, D.L., Ingram, D.K., Navas, P., and de Cabo, R.  Nrf2 mediates cancer protection but not prolongevity induced by caloric restriction. Proc. Natl. Acad. Sci. U S A. 2008, 105(7):2325-30. [PubMed ID: 18287083].

  40. Shalman, R., Kanfi, Y., Pilosof, S.N., Pearson, K.J., Gozlan, Y. M., Lerrer, B., Marine, J.C., Moazed, D., de Cabo, R. and Cohen, H.Y. Regulation of SIRT6 protein levels by nutrient availability. FEBS Lett. 2008,582(5):543-8. [PubMed ID: 182442175].

  41. Minor, R.K., Villarreal, J., McGraw, M., Percival, S.S., Ingram, D.K., de Cabo, R. Calorie restriction alters physical performance but not cognition in two models of altered neuroendocrine signaling. Behav Brain Res. 2008,189(1):202-211. [PubMed ID: 18291538].

  42. Komatsu, T., Chiba, T., Yamaza, H., Yamashita, K., Shimada, A., Hoshiyama, Y., Henmi, T., Ohtani, H., Higami, Y., de Cabo, R., Ingram, D.K. and Shimokawa, I. Manipulation of caloric content but not diet composition, attenuates the deficit in learning and memory of senescence-accelerated mouse strain P8. Exp Gerontol. 2008,43(4):339-46. [PubMed ID: 18316167].

  43. Firestein, R., Blander, G., Michan, S., Oberdoerffer, P., Ogino, S., Campbell, J., Bhimavarapu, A., Luikenhuis, S., de Cabo, R., Fuchs, C., Hahn, W.C., Guarente, L.P., and Sinclair, D.A. The SIRT1 deacetylase suppresses intestinal tumorigenesis and colon cancer growth. PLoS ONE.  2008. 3(4): e2020 doi:10.1371/journal.pone.0002020. [PubMed ID: 18414679].

  44. Csiszar, A., Labinskyy, N., Podlutsky, A., Kaminski, P.M., Wolin, M.S., Zhang, C., Mukhopadhyay, P., Pacher, P., Hu, F., de Cabo, R., Ballabh, P., Ungvari, Z.I. Vasoprotective effects of resveratrol and SIRT1: Attenuation of cigarette smoke-induced oxidative stress and pro-inflammatory phenotypic alterations. Am J Physiol Heart Circ Physiol. 2008, 294(6):H2721-35. [PubMed ID: 18424637].

  45. Pearson, K.J., Baur, J.A., Lewis, K.N., Peshkin, L., Price, N.L., Labinskyy. N., Kamara, D., Minor, R.K., Perez, E., Jamieson, H.A., Zhang, J., Dunn, S.R., Sharma, K., Pleshko, N., Woollett, L.A., Csiszar, A., Ikeno, J., Le Couteur, D., Becker, K.G., Navas, P., Ingram, D.K., Wolf, N.S., Ungvari, Z., Sinclair, D.A., and de Cabo, R. Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life span. Cell Metabolism. 2008. [PubMed ID: 18599363].

  46. Martin, B., Pearson, M., Brenneman, R., Golden, E., Keselman, A., Iyun, T., Carlson, O.D., Egan, J.M., Becker, K.G., Wood, W3rd., Prabhu, V., de Cabo, R., Maudsley, S. and Mattson, M.P. Conserved and differential effects of dietary energy intake on the hippocampal transcriptomes of females and males. PLoS ONE. 2008,3(6):e2398. [PubMed ID: 18545695].

  47. Allard, J.S., Heilbronn, L.K., Smith, C., Hunt, N.D., Ingram, D.K., Ravussin, E., Pennington CALERIE Team, de Cabo, R. In vitro cellular adaptations of biomarkers of longevity in response to treatment with serum collected from humans on calorie restricted diets.  PLoS ONE, 2008 3(9): e3211. [PubMed ID: 18791640].

  48. Csiszar A., Labinskyy N., Pinto J.T., Ballabh P., Zhang H., Losonczy G., Pearson K.J., de Cabo R., Pacher P., Zhang C., Ungvari Z.I. Resveratrol induces mitochondrial biogenesis in endothelial cells. (2009) Am J Physiol Heart Circ Physiol, 297(1):H13-20. [PubMed ID: 19429820].

  49. Jiménez-Hidalgo M., Santos-Ocaña C., Padilla S., Villalba J.M., Lopez-Lluch G., Martín-Montalvo A., Minor R.K., Sinclair D.A., de Cabo R. * and Navas P. NQR1 controls lifespan by regulating the promotion of respiratory metabolism in yeast. Aging Cell. 2009 Feb 3. [PubMed ID: 19239415].                
    (*co-senior and co-corresponding authors)

  50. Brea-Calvo, G., Siendones, E., Sánchez-Alcázar J.A., de Cabo, R and  Navas, P. Cell survival to chemotherapy depends on NF-kB transcriptional up-regulation of coenzyme Q biosynthesis. PLoS One. 2009; 4(4):e5301. [PubMed ID: 19390650].

  51. Abdelmohsen, K., Srikantan, S., Yang, X., Lal, A., Kim, H.H., Kuwano, Y., Galban, S., Becker, K.G., Kamara, D., de Cabo, R., and Gorospe, M. Ubiquitin-mediated proteolysis of HuR by heat shock. EMBOJ. 2009 May 6; 28 (9):1271-82. [PubMed ID: 19322201].

  52. Csiszar A., Labinskyy N., Jimenez R., Pinto J.T., Ballabh P., Losonczy G., Pearson K.J., de Cabo R., and Ungvari Z. Anti-oxidative and anti-inflammatory vasoprotective effects of caloric restriction in aging: Role of circulating factors and SIRT1. Mech Ageing Dev. 2009;130(8):518-27. [PubMed ID: 19549533].

  53. Montori-Grau, M., Minor, R.K., Lerin, C., Allard, J.S., Garcia-Martinez, C., de Cabo, R.,* and  Gómez-Foix, A.M.*  Effects of aging and calorie restriction on rat skeletal muscle glycogen synthase and glycogen phosphorylase. Exp. Gerontol. 2009; 44(6-7):426-33. [PubMed ID: 19341787]. (*co-senior and co-corresponding authors)

  54. Csiszar, A., Labinskyy, N., Olson, S., Pinto, J.T., Gupte, S., Wu, J.M., Hu, F., Ballabh, P., Podlutsky, A., Losonczy, G., de Cabo, R., Mathew, R., Wolin, M.S., Ungvari, Z. Resveratrol Prevents Monocrotaline-Induced Pulmonary Hypertension in Rats. Hypertension. 2009; 54(3):668-75.[PubMed ID: 19597040].

  55. de Cabo, R., Navas, P. "AcCoA"lade for energy and life span. Cell Metab. 2009; 9(4): 305-6. [PubMed ID: 19356710].

  56. Nasrin, N, Virendar, K.K., Fortier, E., Wall, D., Pearson, K.J., de Cabo, R., Bordone, L. Jnk1 phosphorylates sirt1 and promotes its enzymatic activity. PLoS ONE. 2009. 4(12):e8414 [PMID: 20027304]

  57. Minor, R.K., Smith, D.L., Sossong, A.M., Kaushik, S., Poosala, S., Spangler, E.L., Roth, G.S., Lane, M., Allison, D.B., de Cabo, R., Ingram, D.K., Mattison, J.A. Chronic ingestion of 2-deoxy-D-glucose induces cardiac vacuolization and increases mortality in rats. Toxicol Appl Pharmacol. 2010 Mar 15;243(3):332-9. Epub 2009 Dec 22. PubMed PMID: 20026095; PubMed Central PMCID: PMC2830378.

  58. Ungvari ZI, Bagi Z, Feher A, Recchia FA, Sonntag WE, Pearson KJ, de Cabo R, Csiszar A. Resveratrol confers endothelial protection via activation of the antioxidant transcription factor Nrf2. Am J Physiol Heart Circ Physiol. 2010 Apr [Epub ahead of print] PubMed PMID: 20418481.

  59. Minor RK, Allard JS, Younts CM, Ward TM, de Cabo R. Dietary Interventions to Extend Life Span and Health Span Based on Calorie Restriction. J Gerontol A Biol  Sci Med Sci. 2010 Apr 6. [Epub ahead of print] PubMed PMID: 20371545.

  60. Cheng WH, Bohr VA, de Cabo R. Nutrition and aging. Mech Ageing Dev. 2010 Apr 1. [Epub ahead of print] PubMed PMID: 20362608.

  61. Kisby GE, Kohama SG, Olivas A, Churchwell M, Doerge D, Spangler E, de Cabo R, Ingram DK, Imhof B, Bao G, Kow YW. Effect of caloric restriction on base-excision repair (BER) in the aging rat brain. Exp Gerontol. 2010 Mar;45(3):208-16. PubMed PMID: 20005284; PubMed Central PMCID: PMC2826610.

  62. Michan S, Li Y, Chou MM, Parrella E, Ge H, Long JM, Allard JS, Lewis K, Miller M, Xu W, Mervis RF, Chen J, Guerin KI, Smith LE, McBurney MW, Sinclair DA, Baudry M, de Cabo R, Longo VD. SIRT1 is essential for normal cognitive function and synaptic plasticity. J Neurosci. 2010;30(29):9695-707. PubMed PMID:20660252; PubMed Central PMCID: PMC2921958.

  63. Hyun DH, Mughal MR, Yang H, Lee JH, Ko EJ, Hunt ND, de Cabo R, Mattson MP. The plasma membrane redox system is impaired by amyloid b-peptide and in the hippocampus and cerebral cortex of 3xTgAD mice. Exp Neurol. 2010;225(2):423-9. Epub 2010 Jul 27. PubMed PMID: 20673763; PubMed Central PMCID:PMC2946538.

  64. Le Couteur DG, Benson VL, McMahon AC, Blyth F, Handelsman DJ, Seibel MJ, Kennerson M, Naganathan V, Cumming RG, de Cabo R. Determinants of serum-induced SIRT1 expression in older men: the CHAMP study. J Gerontol A Biol Sci Med Sci 2011;66(1):3-8. Epub 2010 Sep 5. PubMed PMID: 20819794.

  65. Baur JA, Chen D, Chini EN, Chua K, Cohen HY, de Cabo R, Deng C, Dimmeler S, Gius D, Guarente LP, Helfand SL, Imai S, Itoh H, Kadowaki T, Koya D, Leeuwenburgh C, McBurney M, Nabeshima Y, Neri C, Oberdoerffer P, Pestell RG, Rogina B, Sadoshima J, Sartorelli V, Serrano M, Sinclair DA, Steegborn C, Tatar M, Tissenbaum HA, Tong Q, Tsubota K, Vaquero A, Verdin E. Dietary restriction: standing up for sirtuins. Science. 2010;329(5995):1012-3; author reply1013-4. PubMed PMID: 20798296.

  66. Ungvari ZI, Bailey-Downs L, Gautam T, Jimenez R, Losonczy G, Zhang C, Ballabh P, Recchia FA, Wilkerson DC, Sonntag WE, Pearson KJ, de Cabo R, Csiszar A. Adaptive induction of NF-E2-Related Factor-2-driven antioxidant genes in endothelial cells in response to hyperglycemia. Am J Physiol Heart Circ Physiol. 2011 Jan 7. [Epub ahead of print] PubMed PMID: 21217061.

  67. Mouton PR, Kelley-Bell B, Tweedie D, Spangler EL, Perez E, Carlson OD, Short RG, de Cabo R, Chang J, Ingram DK, Li Y, Greig NH. The effects of age and lipopolysaccharide (LPS)-mediated peripheral inflammation on numbers of central catecholaminergic neurons. Neurobiol Aging. 2010. [Epub ahead of print] PubMed PMID: 21093964.

  68. Jodar L, Mercken EM, Ariza J, Younts C, Gonzalez-Reyes JA, Alcain FJ, Buron I, de Cabo R, Villalba JM. Genetic Deletion of Nrf2 Promotes Immortalization and Decreases Life Span of Murine Embryonic Fibroblasts. J Gerontol A Biol Sci Med Sci. 2010. [Epub ahead of print] PubMed PMID: 20974733.

  69. Miller RA, Harrison DE, Astle CM, Baur JA, Boyd AR, de Cabo R, Fernandez E, Flurkey K, Javors MA, Nelson JF, Orihuela CJ, Pletcher S, Sharp ZD, Sinclair D, Starnes JW, Wilkinson JE, Nadon NL, Strong R. Rapamycin, but not resveratrol or simvastatin, extends life span of genetically heterogeneous mice. J Gerontol A Biol Sci Med Sci. 2011 Feb;66(2):191-201. Epub 2010. PubMed PMID:20974732; PubMed Central PMCID: PMC3021372.

  70. Guevara-Aguirre J, Balasubramanian P, Guevara-Aguirre M, Wei M, Madia F, Cheng CW, Hwang D, Martin-Montalvo A, Saavedra J, Ingles S, de Cabo R, Cohen P, Longo VD. Growth hormone receptor deficiency is associated with a major reduction in pro-aging signaling, cancer, and diabetes in humans. Sci Transl Med. 2011 Feb 16;3(70):70ra13.

  71. Mitchell SJ, Huizer-Pajkos A, Cogger VC, McLachlan AJ, Le Couteur DG, Jones B, de Cabo R, Hilmer SN. Age-Related Pseudocapillarization of the Liver Sinusoidal Endothelium Impairs the Hepatic Clearance of Acetaminophen in Rats. J Gerontol A Biol Sci Med Sci. 2011 Feb 7. [Epub ahead of print] PMID:21300741

  72. Hyun DH, Kim J, Moon C, Lim CJ, de Cabo R, Mattson MP. The plasma membrane redox enzyme NQO1 sustains cellular energetics and protects human neuroblastoma cells against metabolic and proteotoxic stress. Age (Dordr). 2011 Apr 13. [Epubahead of print] PubMed PMID: 21487704.

  73. Bernier M, Paul RK, Martin-Montalvo A, Scheibye-Knudsen M, Song S, He HJ, Armour SM, Bohr VA, Wang L, Zong Y, Sinclair DA, de Cabo R. Negative regulation of STAT3-mediated cellular respiration by SirT1. J Biol Chem. 2011 Apr 5. [Epub ahead of print] PubMed PMID: 21467030.

  74. Minor RK, Lopez M, Younts CM, Jones B, Pearson KJ, Michael Anson R, Dieguez C, de Cabo R. The arcuate nucleus and neuropeptide Y contribute to the antitumorigenic effect of calorie restriction. Aging Cell. 2011 Mar 8. doi: 10.1111/j.1474-9726.2011.00693.x. [Epub ahead of print] PubMed PMID: 21385308.

  75. Manaye KF, Allard JS, Kalifa S, Drew AC, Xu G, Ingram DK, de Cabo R, Mouton PR. 17α-estradiol attenuates neuron loss in ovariectomized Dtg AβPP/PS1 mice. J Alzheimers Dis. 2011;23(4):629-39.
  76. Findeisen HM, Pearson KJ, Gizard F, Zhao Y, Qing H, Jones KL, Cohn D, Heywood EB, de Cabo R, Bruemmer D. Oxidative Stress Accumulates in Adipose Tissue during Aging and Inhibits Adipogenesis. PLoS One. 2011 Apr 14;6(4):e18532. PubMed PMID: 21533223.
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