National Institute on Aging
National Institutes of Health 		NIA Home
Research Programs
Intramural
Rafael de Cabo, Ph.D. Rafael de Cabo, Ph.D., Investigator
Aging, Metabolism, and Nutrition Unit
Laboratory of Experimental Gerontology
E-mail: deCaboRa@grc.nia.nih.gov
Education
1993 - Licentiate degree, Córdoba University, Córdoba, Spain
2000 - Ph.D., Nutrition, Purdue University, West Lafayette, Indiana
Scientific Training
1988-1993 - Proctor and Research Assistant, Department of Cell Biology and Histology, Córdoba University, Spain
1993-1994 - Visiting Research Scholar, Department of Medicinal Chemistry and Pharmacognosy, Purdue University, West Lafayette, Indiana
1994-2000 - Graduate Student, Department of Foods and Nutrition, Purdue University, West Lafayette, Indiana
2000-2004 - Postdoctoral IRTA Fellow, Laboratory of Neurosciences, National Institute on Aging, NIH, Baltimore, Maryland
2004-Present - Tenure-track Investigator, Laboratory of Experimental Gerontology, National Institute on Aging, NIH, Baltimore, Maryland
Languages Fluent in Spanish and English
Teaching Experience
Purdue University, West Lafayette, IN
August 1994-April 2000 - Teaching Assistant, Department of Foods and Nutrition
College of Notre Dame of Maryland, Baltimore, MD
August 2000-May 2004 - Invited Lecturer of Physiology of Aging Graduate Course
Universidad Pablo de Olavide, Sevilla, Spain
January 2001 - Invited Lecturer to Graduate course "Anàlisis experimental en Biología"
October 2001 - Invited Lecturer, Department of Environmental Sciences, Area of Cell Biology
March 2002 - Invited Lecturer, Department of Environmental Sciences, Area of Cell Biology
October 2002 - Invited Lecturer, Department of Environmental Sciences, Area of Cell Biology
March 2004 - Invited Lecturer, Department of Environmental Sciences, Area of Cell Biology. Graduate course "Subcellular fractionation and characterization methods"
March 2006 - Invited Lecturer, Department of Environmental Sciences, Area of Cell Biology. Graduate course "Subcellular fractionation and characterization methods"
March 2007 - Invited Lecturer, Department of Environmental Sciences, Area of Cell biology, Graduate course "Subcellular fractionation and characterization methods"
Publications
  1. de Cabo, R. Gonzalez-Reyes, J.A. and Navas, P. The onset of cell proliferation is stimulated by ascorbate free radical in onion root primordia. Biol. Cell. 1993; 77: 232-233.
  2. Morré, D.J., Navas, P., Rodriguez-Aguilera, J.C., Morré, D.M., Villalba, J.M., de Cabo, R. and Lawrence, J. Cyclic AMP plus ATP-dependent modulation of the NADH oxidase activity of porcine liver plasma membranes. Biochim. Biophys. Acta. 1994; 1224: 566-574.
  3. Morré, D.J., de Cabo, R., Jacobs, E. and Morré, D.M. Auxin stimulate protein disulfide isomerase from soybean plasma membranes. Plant Physiol. 1995; 109: 573-578.
  4. Morré, D.J., de Cabo, R., Farley, C., Oberlies, N.H. and McLaughlin, J.L. Mode of action of bullatacin, a potent antitumor acetogenin: Inhibition of NADH oxidase of HeLa and HL-60, but not liver, plasma membranes. Life Sci. 1995; 56-5: 343-348.
  5. Jacobs, E., Morré, D.J., de Cabo, R., Sweeting, M. and Morré, D.M. Response of a protein disulfide isomerase-like activity of transitional endoplasmic reticulum to all-trans retinol. Life Sci. 1996; 59-4: 273-284.
  6. de Cabo, R. Gonzalez-Reyes, J.A. and Navas, P. Root sprouting is synchronized in onions by ascorbate free radical. J. Plant Growth Regulation. 1996; v. 15 (2):53-56.
  7. Morré, D.J., Sun, E., Geilen, C., Wu, L-Y., de Cabo, R., Krasagakis, K., Orfanos, C. and Morré, D.M. Capsaicin inhibits plasma membrane NADH oxidase and growth of human and mouse melanoma lines. Eur. J. Cancer. 1996; 32A: 1995-2003.
  8. Morré, D.J., Jacobs, E., Sweeting., M., de Cabo, R., and Morré, D.M. A protein disulfide-thiol interchange activity of HeLa plasma membranes inhibited by the antitumor sulfonylurea N-(4-methylphenylsulfonyl)-N’-(chlorophenyl)urea (LY181984). Biochem. Biophys. acta. 1997; 1325: 117-125.
  9. Navarro, F., Navas, P., Burgess, J.R., Bello, R.I. de Cabo, R., Arroyo, A. and Villalba, J. M. Vitamin E and selenium deficiency induces expression of the ubiquinone-dependent antioxidant system at the plasma membrane. FASEB J. 1998; 12: 1665-1673.
  10. Navarro, F. Arroyo, A., Martin, S.F., Bello, R.I. de Cabo, R., Burgess, J.R., Navas, P and Villalba, J. M. Protective role of ubiquinone against oxidative stress caused by vitamin E and Selenium deficiency. Biofactors. 1999; 9(2-4): 171-177.
  11. Mattes, R.D., Westby, E., de Cabo, R. and Falkner, B. Dietary compliance among salt-sensitive and salt-insensitive normotensive adults. Am. J. Med. Sci., 1999; 315(5): 287-294.
  12. Arroyo, A., Kagan V.E., Tyurin, V.A., Burgess, J.R., de Cabo, R., Navas, P. and Villalba, J.M. NADH and NADPH-dependent reduction of coenzyme Q at the plasma membrane. Antioxid Redox Signal. 2000; 2(2): 251-262.
  13. Navas, P., Fernández-Ayala, D.M., Martin, S.F., López-Lluch, G., de Cabo, R., Rodríguez-Aguilera, J.C. and Villalba, J.M. Ceramide-dependent caspase 3-activation is prevented by coenzyme Q from plasma membrane in serum-deprived cells. Free Radic Res. 2002; 36 (4): 369-374.
  14. Anson, R.M., Guo, Z., de Cabo, R., Lyun, T., Rios, M., Hagepanos, A., Ingram, D.K., Lane, M. A. and Mattson, M.P. Periodic fasting dissociates beneficial effects of dietary restriction from calorie intake. Proc. Nat. Acad. Sci. USA. 2003; 100: 6216-6220.
  15. de Cabo, R., Fürer-Galban, S., Anson, R.M., Gilman, C., Gorospe, M., Lane, M.A. An In Vitro model of caloric restriction. Exp. Gerontology. 2003; 38: 631-639. Article featured in Science magazine on-line SAGE-KE and Science, July 9th 2003 (B.S. Kristal, U. Paolucci, Caloric Restriction in trans. Sci. SAGE KE 2003).
  16. de Cabo, R., López, G., Cabello, R., Lane, M., Navas P. Effects of age and Calorie Restriction on the Rat Liver Antioxidant Plasma Membrane Redox System. Exp. Gerontol. 2004; 39(3): 297-304.
  17. Cohen, H.Y., Miller, C., Bitterman, K.J., Wall, N.R., Hekking, B., Kessler, B., Gorospe, M., de Cabo, R. and Sinclair, D.A. Calorie restriction promotes cell survival by inducing SIRT1. Science. 2004; 305(5682): 390-392.
  18. Zhu, M., Miura, J., Lu, L., Bernier, M., de Cabo, R., Lane, M.A., Roth, G.S., Ingram, D.K. Circulating adiponectin levels increase in rats on caloric restriction: the potential for insulin sensitization. Exp. Gerontology. 2004; 39(7): 1049-1059.
  19. Lane, M.A., de Cabo, R., Mattison, J., Anson, R.M., Roth, G.S. and Ingram, D.K. The Roy Walford legacy: diet restriction from molecules to mice to monkeys to man and onto mimetics. Exp. Gerontol. 2004; 39(6): 897-902.
  20. Ingram, D.K., Anson, R.M., de Cabo, R., Mattison, J., Mamczarz, J., Zhu, M., Lane, M.A. and Roth, G.S. Development of calorie restriction mimetics as a prolongevity strategy. Ann. NY Acad. Sci. 2004; 1019: 412-423.
  21. Zhu, M., de Cabo, R., Lane, M.A. and Ingram, D.K. Caloric restriction modulates early events in insulin signaling in liver and skeletal muscle of rat. Ann. NY Acad. Sci. 2004; 1019: 448-452.
  22. Vega, V., de Cabo, R. and DeMaio, A. Age and caloric restriction diets are confounding factors that modify the response to lps by peritoneal macrophages from c57bl/6 mice. Shock. 2004; 22(3):2 48-253.
  23. Zhu, M., de Cabo, R., Anson, R.M., Ingram, D.K. and Lane, M. A. Caloric restriction modulates early events in insulin signaling in liver and skeletal muscle of Rat. Nutrition. 2005; 21(3): 378-388.
  24. Anson, R.M., Jones, B. and de Cabo, R. The diet restriction paradigm: a brief review of the effects of every- other- day feeding. AGE. 2005; 27(1): 17-25.
  25. Navas, P., and de Cabo R. Plasma membrane and aging. Guest editorial. AGE. 2005; 27 (2): 127.
  26. Lopez-Lluch, G., Rios, M., Lane, M.A., Navas, P. and de Cabo, R. Mouse liver plasma membrane redox system activity is altered by aging and modulated by calorie restriction. AGE. 2005; 27(2): 153-160.
  27. Lopez-Lluch, G., Hunt, N., Jones, B., Zhu, M., Jamieson, H., Hilmer, S., Cascajo, M.V., Allard, J., Ingram, D.K. and de Cabo, R. Calorie restriction induces mitochondrial biogenesis and bioenergetic efficiency. Proc. Natl. Acad. Sci. USA. 2006; 103(6):1768-1773.
  28. Bernier, M., Kwon, Y.K., Pandey, S.K., Zhu, T.N., Zhao, R.J., Maciuk, A., He, H.J., de Cabo, R., and Kole, S. Binding of manumycin A inhibits IKB kinase beta activity. J. Biol. Chem. 2006; 281(5):2551-2561.
  29. Liu, D., Chan, S.L., de Souza-Pinto, N.C., Slevin, J., Wersto, R.P., Zhan, M., Mustafa, K., de Cabo, R and Mattson, M.P. Mitochondrial UCP4 mediates an adaptive shift in energy metabolism and increases the resistance of neurons to metabolic and oxidative stress. Neuromolecular Med. 2006;8(3):389-414.
  30. Ingram, D.K., Zhu, M., Mamczarz, J., Zou, S., Lane, M.A., Roth, G.S. and de Cabo, R. Calorie restriction mimetics: an emerging research field. Aging Cell. 2006, 5(2):97-108.
  31. Hyun, D.H., Hernandez, J.O., Mattson, M.P. and de Cabo, R. The plasma membrane redox system in aging. Aging Res. Rev. 2006;5(2):209-220.
  32. Hunt, N., Hyun, D.H., Allard, J., Minor, R., Ingram, D.K. and de Cabo, R. Bioenergetics of aging and caloric restriction. Aging Res. Rev. 2006;5(2):125-143.
  33. Ingram, D. K., Roth, G.S., Lane, M. A., Ottinger, M.A., Zuo, S., de Cabo, R., and Mattison, J. The potential for diet restriction to increase longevity in humans: extrapolation from monkey studies. Biogerontology. 2006; 7(3):143-148.
  34. de Cabo, R., Burgess, J.R. and Navas, P. Early events of the redox adaptations induced by vitamin E deficiency in rat liver. J. Bioenerg. Biomembr. 2006;38(5-6):309-317.
  35. Qin, W., Chachich, M., Lane, M.A., Roth, G., de Cabo, R., Ottinger, M.A., Mattison, J., Ingram, D.K., Gandy, M and Pasinetti, G.M. Neuropathology in squirrel monkeys (Saimiri sciureus). J. Alzheimers Dis. 2006;10(4):417-422.
  36. Lee, G.D., Wilson, M.A., Zhu, M., Wolkow, C.A., de Cabo, R., Ingram, D.K. and Zou, S. Dietary deprivation extends lifespan in Caenorhabditis elegans. Aging Cell. 2006;5(6):515-524.
  37. Baur, J.A., Pearson, K. J., Price, N., Jamieson, H. A., Lerin, C., Kalra, A., Prabhu, V.V., Allard, J.S., Lopez-Lluch, G., Lewis, K., Pistell, P., Poosala, S., Becker, K.G., Boss, O., Gwinn, D., Wang, M., Ramaswamy, S., Fishbein, K.W., Spencer., R.G., Lakatta, E.G., Le Couteur, D., Shaw, R.G., Navas, P., Puigserver, P., Ingram, D.K., de Cabo, R., and Sinclair, D.A. Resveratrol improves health and increases survival of mice on a high-calorie diet. Nature. 2006; 444(7117):337-342.
  38. Hyun, D.H., Emerson, S.S., Jo, D. J., Mattson, M.P. and de Cabo, R. Calorie restriction up-regulates the plasma membrane redox system in brain cells and suppresses oxidative stress during aging. Proc. Natl. Acad. Sci. USA. 2006;103(52):19908-19912.
  39. Hyun, D.H., Emerson, S.S., Hunt, N., Mattson, M.P. and de Cabo, R. Up-regulation of plasma membrane-associated redox activities in neuronal cells lacking functional mitochondria. J. Neurochem. 2007;100(5):1364-1374.
  40. Jamieson, H., Hilmer, S., Cogger, V.C., Warren, A., Cheluvappa, R., Abernethy, D. R., Fraser, R., de Cabo R. and Le Couteur , D. G. Caloric restriction dramatically reduces age-related pseudocapillarization of the hepatic sinusoid. Exp. Geron. 2007;42(4):374-378.
  41. Minor, R.K., Smith, C.I., de Cabo, R., Ingram, D.K. Food for life: Maximising lifespan through the diet Agro Food Industry Hi-Tech. 2007;18(1), pp. 36-39.
  42. Zou, S., Sinclair, J., Wilson, M.A., Carey, J., Liedo, P., Oropeza, A., Kalra, A., de Cabo, R., Ingram, D.K., Longo, D.L. and Wolkow, C.A. Comparative approaches to facilitate pharmacological studies of longevity: Effects of tocopherols on lifespan in short-lived invertebrates. Mech. Ageing Dev. 2007;128(2):222-226.
  43. Navas, P., Villalba, J.M., and de Cabo, R. The importance of plasma membrane coenzyme Q in aging and stress responses. Mitochondrion. 2007;Suppl 1:S34-S40.
  44. Jamieson, H. A., Cogger, V. C., Twigg, S. M., McLennan, S. V., Warren, A., Cheluvappa, R., Hilmer, S.N., Fraser, R., de Cabo, R. and Le Couteur, D.G. Alterations in liver sinusoidal endothelium in a baboon model of type 1 diabetes. Diabetologia. 2007;50(9):1969-1976.
  45. Zhu, M., Lee, G.D., Ding, L., Hu, J., Qiu, G., de Cabo, R., Bernier, M., Ingram, D.K., Zou, S. Adipogenic signaling in rat white adipose tissue: Modulation by aging and calorie restriction. Exp. Gerontol. 2007;42(8):733-744.
  46. Yang, H., Yang, T., North, B., Baur, J.A., Perez, E., Matsui, T., Carmona, J., Lamming, D.W., Medvedik, O., Maynard, T., Miller, R., Rosenzweig, A., de Cabo, R., Sauve, A. A., and Sinclair, D. A. Nutrient-regulated mitochondrial NAD+ biosynthesis promotes cell survival via SIRT3 and SIRT4. Cell. 2007;130(6):1095-1107.
  47. Kisby, G.E., Kohama, S.E., Olivas, A., Spangler, E., de Cabo. R., Ingram D.K., Imhof, B., O'Neil, B., Koshy, M. and Kow Y.W. Effect of caloric restriction on base excision repair (BER) in the aging rat brain. Neurobiology of Aging. In press.
  48. Le Couteur, D.G., Warren, A., Cogger, V.C., Smedsrod, B., Sorensen, K.K., de Cabo, R., Fraser, R. and McCuskey, R.S. Old age and the hepatic sinusoid. Anat. Records. In press, 2007.
  49. Le Couteur, D.G., Warren, A., Cogger, V.C., Smedsrod, B., Sorensen, K.K., de Cabo, R., Fraser, R. and McCuskey, R.S. Age-related changes in the liver sinusoidal endothelium are a mechanism for dyslipidemia. Ann. NY Acad. Sci. In press, 2007.
  50. Duffy, K.B., Spangler, E.L., Devan, B.D., Guo, Z., Bowker, J.L., Janas, A.M., Hagepanos, A., Minor, R.K., de Cabo, R., Mouton, P.R., Shukitt-Hale, B., Joseph, J.A., Ingram, D.K. A blueberry-enriched diet provides cellular protection against oxidative stress and reduces a kainate-induced learning impairment in rats. Neurobiol. Aging. In press, 2007.
Invited Presentations
de Cabo, R. Gonzalez-Reyes, J.A. and Navas, P. Ascorbate Free Radical Facilitates G0 ® G1 Transition in Onion Roots Quiescent Cells. Biochemical Mechanism Involved in Growth Regulation (BMGR), International Symposium. 1991, Milan, Italy.
Navas. P., de Cabo, R., Navarro, F., Rodriguez-Aguilera, J.C.,Gonzalez-Reyes, J.A. and Buron, I. Ascorbate Facilitates the Transit from Quiescent to Division in Eukaryotic Cells. Texas Society for Electron Microscopy. 1991, Clear Lake, Texas.
de Cabo, R. An in vitro model of enhanced stress responsiveness by caloric restriction: A novel method for evaluation of possible mechanisms and candidate caloric restriction mimetics. American Aging Association. 2001, Madison, Wisconsin.
de Cabo, R. An in vitro model to study caloric restriction. Universidad Pablo de Olavide, Sevilla. October, 2001, Sevilla, Spain.
de Cabo, R. Age and calorie restriction effects on C57BL6 liver plasma membrane antioxidant redox system. Universidad Pablo de Olavide, Sevilla. February, 2002, Sevilla, Spain.
de Cabo, R. Plasma membrane redox system: possible role on the underlying mechanisms of calorie restriction. Current Perspectives on the Mechanism of Caloric Restriction. 2002, Bandera, Texas.
de Cabo, R. Aging and Calorie Restriction: Effects on Intraperitoneal Macrophages. 2002, Department of Pediatrics, John's Hopkins Medical Institution, Baltimore, Maryland.
de Cabo, R. The Plasma Membrane Redox System During Aging and Calorie Restriction. Workshop, Molecular Biology and Function of Plasma Membrane Redox, UCLA, USA. March 2004, Los Angeles, California.
de Cabo, R. Development and Characterization of A Novel In Vitro Model to Study Caloric Restriction. Universidad Nacional de Colombia. September, 2003. Bogotà, Colombia.
de Cabo, R. Is the Messenger for the Cytoprotective Effects of Calorie Restriction in the Blood? Gerontology Society of America. November 2004, San Diego, California.
de Cabo, R. Eat less, live longer. Department of Pediatrics, John's Hopkins Medical Institution. March 2004, Baltimore, Maryland.
de Cabo, R. New Insights on Mechanisms of Calorie Restriction: An In Vitro Model and the Plasma Membrane Redox System. Department of Animal and Avian Sciences. University of Maryland. October 2004, College Park, Maryland.
de Cabo, R. Eat Less, Live Longer: Caloric Restriction and Aging. Depts. of Biol. Sciences and Chemistry. Goucher College. November 2004, Baltimore, Maryland.
de Cabo, R. Calorie restriction and aging alter rat liver plasma membrane antioxidant system. Marion Bessin Liver Research Center. Albert Einstein College of Medicine. November 2004, New York, New York.
de Cabo, R. Biology of Aging Lecture. Dept. of Biol. Sciences. Johns Hopkins University. April 2005, Baltimore, Maryland.
de Cabo, R. Calorie restriction and aging alter rat liver plasma membrane antioxidant system. Kentucky University. May 2005, Lexington, Kentucky.
de Cabo, R. New Insights on Mechanisms of Calorie Restriction: An In Vitro Model and the Plasma Membrane Redox System. Washington University. May 2005, Seattle, Washington.
de Cabo, R. Biology of Aging Lecture. ANZAC center. Sidney, Australia. November 2005, Sidney, Australia.
de Cabo, R. Calorie restriction and aging alter rat liver plasma membrane antioxidant system. CERA. Sidney, Australia. November 2005, Sidney, Australia.
de Cabo, R. New insights on mechanisms of calorie restriction: an in vitro model and the plasma membrane redox system. Concord Hospital. Concord, Sidney, Australia. November 2005, Concord, Sydney, Australia.
de Cabo, R. Biology of aging and calorie restriction lecture. Oxford Hospital. Sidney, Australia. November 2005, Oxford, Sidney, Australia.
de Cabo, R. More and better mitochondria: A key anti-aging mechanism of caloric restriction. Department of Biotechnology. University of Natural Resources and Applied Life Sciences. November 2005, Vienna, Austria.
de Cabo, R. Mechanisms of calorie restriction: an in vitro model and the plasma membrane redox system. Institute for Biomedical Aging Research of the Austrian Academy of Sciences. November 2005, Innsbruck, Austria.
de Cabo, R. Biology of aging and calorie restriction lecture. The Johns Hopkins University Department of Psychological and Brain Sciences. May 2006, Baltimore, Maryland.
de Cabo, R. More and better mitochondria: A key anti-aging mechanism of caloric restriction. Novartis, Boston, Massachusetts
de Cabo, R. Effects of Resveratrol in mice on a high calorie diet. The Johns Hopkins University Department of Biology. June 2006, Baltimore, Maryland.
de Cabo, R. Effects of Resveratrol in mice on a high calorie diet. Switzerland. January 2007, Baltimore, Maryland.
de Cabo, R. In Vino Veritas; Manipulando el Envejecimiento y la Longevidad. Universidad de Cordoba. March 2007, Cordoba, Spain.
de Cabo, R. Lifespan extension by Resveratrol. AGE meeting. June 2007, San Antonio, Texas.
Grants
Regulación de la biosíntesis del coenzima Q en eucariontes. Universidad Pablo de Olavide ((BMC2002-01602)168,000 €). P.I; Plácido Navas Lloret, 2003-2005.
Role of quinone reductase activity in the control of proliferation and senescence in animal cells. Universidad de Córdoba. P.I; José Manuel Villalba, 2006-2010.
Dietary restriction, aging and the proteasome. RO1. University of Kentucky. P.I; Jeffrey Keller, 2005-2009.
The effect of maternal diet supplementation with blueberries on outcomes from hypoxic-ischemic injury in rat pups. NIA and Johns Hopkins University. P.I; Rafael de Cabo, Anne Burke and Cynthia Holcroft. 2005-2006.
Scientific Awards
CERA Visiting professor (The Centre for Education and Research on Ageing) University of Sydney and Concord Hospital. Sydney. Australia.
The American Aging Association Postdoctoral 2001, Paul E. Glenn Award for Meritorious Research.
Young Scientist Award presented at the 26th conference of the Shock Society.
The American Aging Association Postdoctoral 2003, Paul E. Glenn runner up Award for Meritorious Research.
Invited Reviewer for Journals
Free Radicals in Biology and Medicine, Journal of Cell Science, Journal of Anti-Aging Medicine, Journal of Neurochemistry, Journal of Neuroscience Methods, Neurobiology of Aging, Journal of the American Aging Association, Gerontology, Experimental Aging Research, Ageing Research Reviews, Experimental Biology and Medicine, Mechanisms of Ageing and Development
Activities in Professional Societies
Member of the Board, American Aging Association, 2006
Other Academic Activities
President, Department of Foods and Nutrition Graduate Students Committee (Aug. 1996 - 1998)
Senator, Purdue University Student Government (Aug. 1997-1998)
Student Chapter Committee, American Aging Association
Societies
American Society for Cell Biology
American Aging Association
Gerontological Society of America
American Association for the Advancement of Science
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