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Joanne Stacey Allard, Ph.D., Postdoctoral IRTA Fellow
Behavioral Neuroscience Section
Laboratory of Experimental Gerontology

E-mail: allardj@mail.nih.gov
Research Summary: The effects of calorie restriction (CR) on health and longevity has been studied extensively revealing its powerful ability to slow down the aging process and delay the progression of many age-related diseases including Alzheimer's and cancer. Several studies have reported that many of the health benefits seen with CR; including lowered body fat, increased insulin sensitivity, delayed disease progression and increased neuroprotection can also be obtained through regular exercise training. However, while CR extends mean as well as maximum lifespan, exercise training has been shown to extend mean life span without the concomitant extension of maximal lifespan. My research interest focuses on making comparisons between the mechanisms by which exercise and CR effect longevity, in an attempt to identify areas of divergence which might explain the differential effect on maximum lifespan.
Education
2004 - Ph.D., Howard University, College of Medicine, Department of Physiology and Biophysics
1993 - B.S., Howard University, Electrical Engineering
Professional Experience
2004-Present Postdoctoral IRTA Fellow, National Institute on Aging, Laboratory of Experimental Gerontology, Behavioral Neuroscience Section
1997-2003 Graduate Teaching Assistant, Howard University, College of Medicine, Department of Physiology and Biophysics
2000-2003 Research Volunteer, National Institute of Alcohol and Alcohol Abuse, Laboratory of Cellular and Molecular Neurobiology and Physiology
1997 Research Volunteer, National Institute of Neurological Disorders and Stroke
1991 Research Trainee, Johns Hopkins University, Department of Biomedical Engineering
Research Techniques
Stereological Analysis, Immunohistochemistry, Intracardial Perfusions, EEG and EMG Animal Electrode Implantation, Sleep Stage Analysis, Stereotaxical Chemical Lesioning and Labeling, PCR, Patch Clamp, In-situ Hybridization
Awards
Sept. 2003 - Aug. 2004 -- GAANN Fellowship Award
Jan. 2002 - Dec. 2002 -- National Institutes of Health, Minority Graduate Research Supplemental Award
March 1996 - Feb. 2001 -- Department of Defense, Computational Neuroscience Graduate Student Fellowship
May 1999 - July-1999 -- Summer Research Fellow, Department of Biology, University of Siena, Italy
Sept. 1988 - May 1992 -- National Competitive Undergraduate Scholarship
Affiliations
Society for Neuroscience
American Physiological Society
Publications
Joanne Allard, Yousef Tizabi, James Shaffery, C. Ovid Trouth, Kebreten Manaye: Stereological Analysis of the Hypothalamic Hypocretin/Orexin Neurons in an Animal Model of Depression. Neuropeptides 2004 Oct; 38(5):311-5.
Young JK, Wu M, Manaye KF, KC P, Allard JS, Mack SO, Haxhiu MA. Orexin Stimulates Breathing via medullary and spinal Pathways. J Appl. Physiol. 2005, Apr: 98(4): 1387-95.
J. P. Shaffery, J.S. Allard, K.F. Manaye, H.P. Roffwarg: Deprivation of Rapid Eye-Movement Sleep for Seven Days Reduces Tyrosine Hydroxylase Immunoreactivity in Kitten Locus Coeruleus and Delta Power in Slow Wave Sleep. (Neuroscience, 2005 submitted).
Abstracts/Presentations
Allard, J.S., J. P. Shaffery, D. Hogan, K. Manaye, J. Johnson, H.P. Roffwarg: Effect of Rapid Eye Movement Sleep Deprivation on the Locus Coeruleus. (SNRP Conference, San Antonio, TX, May 15-17, 2002).
Allard, J.S., Dale Hogan, Joyce Johnson, Howard P. Roffwarg, Kebreten Manaye, C. Ovid Trouth, James P. Shaffery: Rapid Eye-Movement Sleep (REMS) Deprivation in Kittens Affects Tyrosine Hydroxylase (TH) Immunoreactive Cell Density in Locus Coeruleus (LC). Society for neuroscience Abstracts 2001.
P. Kc, W.A. Anderson, J.S. Allard, K.F. Manaye, C.O. Trouth: Morphological Structures at Ventral Brainstem Chemosensitive Sites, 2000 Experimental Biology.
J.W. Peters, J.S. Allard, C.O.: Trouth, Potassium Currents in Neurons from the Ventral Lateral Medulla of Rats Society for Neuroscience Abstracts 22, 348, 1996.
S.D. James, C.O. Trouth, R.M. Douglas, R.W. Durand, J.S. Allard: Localization of C-Fos in Response to Acidic Stimulation of the Rostral Ventrolateral Medulla, Society for Neuroscience Abstracts 21, 1882, 1995.
Invited Talks
National Institute on Deafness and other Communication Disorder (NIH/NIDCD) and Howard University Science Symposium (2002), Howard University College of Medicine, Washington, D.C., Title: The Effect of Rapid EYE movement Sleep Deprivation on TH Immunoreactivity in Locus Coeruleus.
Catholic University of America, Discovery Center, Washington, D.C. Summer Science Enrichment Program 2002 - Title: The Physiological Benefits of Exercise.
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