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Joanne Stacey Allard, Ph.D., Postdoctoral IRTA Fellow Behavioral Neuroscience Section Laboratory of Experimental Gerontology E-mail: allardj@mail.nih.gov |
| Research Summary: The effects of calorie restriction (CR) on health and longevity has been studied extensively revealing its powerful ability to slow down the aging process and delay the progression of many age-related diseases including Alzheimer's and cancer. Several studies have reported that many of the health benefits seen with CR; including lowered body fat, increased insulin sensitivity, delayed disease progression and increased neuroprotection can also be obtained through regular exercise training. However, while CR extends mean as well as maximum lifespan, exercise training has been shown to extend mean life span without the concomitant extension of maximal lifespan. My research interest focuses on making comparisons between the mechanisms by which exercise and CR effect longevity, in an attempt to identify areas of divergence which might explain the differential effect on maximum lifespan. |
| Education |
| 2004 - Ph.D., Howard University, College of Medicine, Department of Physiology and Biophysics 1993 - B.S., Howard University, Electrical Engineering |
| Professional Experience |
| 2004-Present | Postdoctoral IRTA Fellow, National Institute on Aging, Laboratory of Experimental Gerontology, Behavioral Neuroscience Section |
| 1997-2003 | Graduate Teaching Assistant, Howard University, College of Medicine, Department of Physiology and Biophysics |
| 2000-2003 | Research Volunteer, National Institute of Alcohol and Alcohol Abuse, Laboratory of Cellular and Molecular Neurobiology and Physiology |
| 1997 | Research Volunteer, National Institute of Neurological Disorders and Stroke |
| 1991 | Research Trainee, Johns Hopkins University, Department of Biomedical Engineering |
| Research Techniques |
| Stereological Analysis, Immunohistochemistry, Intracardial Perfusions, EEG and EMG Animal Electrode Implantation, Sleep Stage Analysis, Stereotaxical Chemical Lesioning and Labeling, PCR, Patch Clamp, In-situ Hybridization |
| Awards |
| Sept. 2003 - Aug. 2004 -- GAANN Fellowship Award |
| Jan. 2002 - Dec. 2002 -- National Institutes of Health, Minority Graduate Research Supplemental Award |
| March 1996 - Feb. 2001 -- Department of Defense, Computational Neuroscience Graduate Student Fellowship |
| May 1999 - July-1999 -- Summer Research Fellow, Department of Biology, University of Siena, Italy |
| Sept. 1988 - May 1992 -- National Competitive Undergraduate Scholarship |
| Affiliations |
| Society for Neuroscience |
| American Physiological Society |
| Publications |
| Joanne Allard, Yousef Tizabi, James Shaffery, C. Ovid Trouth, Kebreten Manaye: Stereological Analysis of the Hypothalamic Hypocretin/Orexin Neurons in an Animal Model of Depression. Neuropeptides 2004 Oct; 38(5):311-5. |
| Young JK, Wu M, Manaye KF, KC P, Allard JS, Mack SO, Haxhiu MA. Orexin Stimulates Breathing via medullary and spinal Pathways. J Appl. Physiol. 2005, Apr: 98(4): 1387-95. |
| J. P. Shaffery, J.S. Allard, K.F. Manaye, H.P. Roffwarg: Deprivation of Rapid Eye-Movement Sleep for Seven Days Reduces Tyrosine Hydroxylase Immunoreactivity in Kitten Locus Coeruleus and Delta Power in Slow Wave Sleep. (Neuroscience, 2005 submitted). |
| Abstracts/Presentations |
| Allard, J.S., J. P. Shaffery, D. Hogan, K. Manaye, J. Johnson, H.P. Roffwarg: Effect of Rapid Eye Movement Sleep Deprivation on the Locus Coeruleus. (SNRP Conference, San Antonio, TX, May 15-17, 2002). |
| Allard, J.S., Dale Hogan, Joyce Johnson, Howard P. Roffwarg, Kebreten Manaye, C. Ovid Trouth, James P. Shaffery: Rapid Eye-Movement Sleep (REMS) Deprivation in Kittens Affects Tyrosine Hydroxylase (TH) Immunoreactive Cell Density in Locus Coeruleus (LC). Society for neuroscience Abstracts 2001. |
| P. Kc, W.A. Anderson, J.S. Allard, K.F. Manaye, C.O. Trouth: Morphological Structures at Ventral Brainstem Chemosensitive Sites, 2000 Experimental Biology. |
| J.W. Peters, J.S. Allard, C.O.: Trouth, Potassium Currents in Neurons from the Ventral Lateral Medulla of Rats Society for Neuroscience Abstracts 22, 348, 1996. |
| S.D. James, C.O. Trouth, R.M. Douglas, R.W. Durand, J.S. Allard: Localization of C-Fos in Response to Acidic Stimulation of the Rostral Ventrolateral Medulla, Society for Neuroscience Abstracts 21, 1882, 1995. |
| Invited Talks |
| National Institute on Deafness and other Communication Disorder (NIH/NIDCD) and Howard University Science Symposium (2002), Howard University College of Medicine, Washington, D.C., Title: The Effect of Rapid EYE movement Sleep Deprivation on TH Immunoreactivity in Locus Coeruleus. |
| Catholic University of America, Discovery Center, Washington, D.C. Summer Science Enrichment Program 2002 - Title: The Physiological Benefits of Exercise. |
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