National Institute on Aging
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Laboratory of Cellular and Molecular Biology
Publications

  1. Abdelmohsen K, Kuwano Y, Kim HH, Gorospe M. Posttranscriptional gene regulation by RNA-binding proteins during oxidative stress: implications for cellular senescence. Biol Chem. 2008 Jan.; [Epub ahead of print].

  2. Casolaro V, Fang X, Tancowny B, Fan J, Wu F, Srikantan S, Asaki SY, De Fanis U, Huang SK, Gorospe M, Atasoy UX, Stellato C. Posttranscriptional regulation of IL-13 in T cells: Role of the RNA-binding protein HuR. J Allergy Clin Immunol. 2008 Feb.; [Epub ahead of print].

  3. Galban S, Kuwano Y, Pullmann R Jr, Martindale JL, Kim HH, Lal A, Abdelmohsen K, Yang X, Dang Y, Liu JO, Lewis SM, Holcik M, Gorospe M. RNA-binding proteins HuR and PTB promote the translation of hypoxia-inducible factor-1{alpha} Mol Cell Biol. 2008;28(1):93-107.

  4. Gorospe M, de Cabo R. AsSIRTing the DNA damage response. Trends Cell Biol. 2008;18(2):77-83.

  5. Hill JW, Hu JJ, Evans MK. OGG1 is degraded by calpain following oxidative stress and cisplatin exposure. DNA Repair (Amst). 2008;7(4):648-654.

  6. Kim HH, Gorospe M. GU-rich RNA: Expanding CUGBP1 function, broadening mRNA turnover. Mol Cell. 2008;29(2):151-152.

  7. Konecny GE, Agarwal R, Keeney GA, Winterhoff B, Jones MB, Mariani A, Riehle D, Neuper C, Dowdy SC, Wang HJ, Morin PJ, Podratz KC. Claudin-3 and claudin-4 expression in serous papillary, clear-cell, and endometrioid endometrial cancer. Gynecol Oncol. 2008 Feb.; [Epub ahead of print].

  8. Kothapalli N, Norton DD, Fugmann SD. Cutting Edge: A cis-Acting DNA element targets AID-mediated sequence diversification to the chicken Ig light chain gene locus. J Immunol. 2008;180(4):2019-2023.

  9. Lecona E, Olmo N, Turnay J, Santiago-Gomez A, Lopez de Silanes I, Gorospe M, Lizarbe MA. Kinetic analysis of butyrate transport in human colon adenocarcinoma cells reveals two different carrier-mediated mechanisms. Biochem J. 2008;409(1):311-320.

  10. Morin PJ. Learning about ovarian tumorigenesis by watching cables. Cancer Biol Ther. 2008;7(2).

  11. Robinson VL, Shalhav O, Otto K, Kawai T, Gorospe M, Rinker-Schaeffer CW. Mitogen-activated protein kinase kinase 4/c-Jun NH2-terminal kinase kinase 1 protein expression is subject to translational regulation in prostate cancer cell lines. Mol Cancer Res. 2008;6(3):501-508.

  12. Zou T, Liu L, Rao JN, Marasa BS, Chen J, Xiao L, Zhou H, Gorospe M, Wang JY. Polyamines modulate the subcellular localization of RNA-binding protein HuR through AMP-activated protein kinase-regulated phosphorylation and acetylation of importin alpha1. Biochem J. 2008;409(2):389-398.

  13. Abdelmohsen K, Lal A, Kim HH, Gorospe M. Posttranscriptional orchestration of an anti-apoptotic program by HuR. Cell Cycle. 2007;6(11):1288-1292.

  14. Abdelmohsen K, Pullmann R Jr, Lal A, Kim HH, Galban S, Yang X, Blethrow JD, Walker M, Shubert J, Gillespie DA, Furneaux H, Gorospe M. Phosphorylation of HuR by Chk2 regulates SIRT1 expression. Mol Cell. 2007;25(4):543-557.

  15. Chakraborty T, Chowdhury D, Keyes A, Jani A, Subrahmanyam R, Ivanova I, Sen R. Repeat organization and epigenetic regulation of the DH-Cmu domain of the immunoglobulin heavy-chain gene locus. Mol Cell. 2007;27(5):842-850.

  16. D'Souza T, Indig FE, Morin PJ. Phosphorylation of claudin-4 by PKCepsilon regulates tight junction barrier function in ovarian cancer cells. Exp Cell Res. 2007;313(15):3364-3375.

  17. Evans MK, Yu CR, Lohani A, Mahdi RM, Liu X, Trzeciak AR, Egwuagu CE. Expression of SOCS1 and SOCS3 genes is differentially regulated in breast cancer cells in response to proinflammatory cytokine and growth factor signals. Oncogene. 2007;26(13):1941-1948.

  18. Gopal AR, Fugmann SD. AID-mediated diversification within the IgL locus of chicken DT40 cells is restricted to the transcribed IgL gene. Mol Immunol. 2007 Nov.; [Epub ahead of print].

  19. Hill JW, Evans MK. A novel R229Q OGG1 polymorphism results in a thermolabile enzyme that sensitizes KG-1 leukemia cells to DNA damaging agents. Cancer Detect Prev. 2007;31(3):237-243.

  20. Honda H, Pazin MJ, D'Souza T, Ji H, Morin PJ. Regulation of the CLDN3 gene in ovarian cancer cells. Cancer Biol Ther. 2007 August; 6(11) [Epub ahead of print].

  21. Kim HS, Kuwano Y, Zhan M, Pullmann R Jr, Mazan-Mamczarz K, Li H, Kedersha N, Anderson P, Wilce MC, Gorospe M, Wilce JA. Elucidation of a C-rich signature motif in target mRNAs of RNA-binding protein TIAR. Mol Cell Biol. 2007;27(19):6806-6817.

  22. Leotlela PD, Wade MS, Duray PH, Rhode MJ, Brown HF, Rosenthal DT, Dissanayake SK, Earley R, Indig FE, Nickoloff BJ, Taub DD, Kallioniemi OP, Meltzer P, Morin PJ, Weeraratna AT. Claudin-1 overexpression in melanoma is regulated by PKC and contributes to melanoma cell motility. Oncogene. 2007;26(26):3846-3856.

  23. Li J, Wood WH 3rd, Becker KG, Weeraratna AT, Morin PJ. Gene expression response to cisplatin treatment in drug-sensitive and drug-resistant ovarian cancer cells. Oncogene. 2007;26(20):2860-2872.

  24. Liu Y, Subrahmanyam R, Chakraborty T, Sen R, Desiderio S. A plant homeodomain in RAG-2 that binds hypermethylated lysine 4 of histone H3 is necessary for efficient antigen-receptor-gene rearrangement. Immunity. 2007;27(4):561-571.

  25. Nguyen HT, Evans MK, Zonderman AB. Influence of medical conditions on executive and memory functions in low socioeconomic status African Americans. Arch Clin Neuropsychol. 2007;22(6):689-698.

  26. Nyaga SG, Jaruga P, Lohani A, Dizdaroglu M, Evans MK. Accumulation of oxidatively induced DNA damage in human breast cancer cell lines following treatment with hydrogen peroxide. Cell Cycle. 2007;6(12):1472-1478.

  27. Pullmann R Jr, Kim HH, Abdelmohsen K, Lal A, Martindale JL, Yang X, Gorospe M. Analysis of turnover and translation regulatory RBP expression through binding to cognate mRNAs. Mol Cell Biol. 2007;27(18):6265-6278.

  28. Rodriguez H, Jaruga P, Leber D, Nyaga SG, Evans MK, Dizdaroglu M. Lymphoblasts of women with BRCA1 mutations are deficient in cellular repair of 8,5'-Cyclopurine-2'-deoxynucleosides and 8-hydroxy-2'-deoxyguanosine. Biochemistry. 2007;46(9):2488-2496.

  29. Ruggiero C, Metter EJ, Cherubini A, Maggio M, Sen R, Najjar SS, Windham GB, Ble A, Senin U, Ferrucci L. White blood cell count and mortality in the Baltimore Longitudinal Study of Aging. J Am Coll Cardiol. 2007;49(18):1841-1850.

  30. Schwartz EI, Smilenov LB, Price MA, Osredkar T, Baker RA, Ghosh S, Shi FD, Vollmer TL, Lencinas A, Stearns DM, Gorospe M, Kruman II. Cell cycle activation in postmitotic neurons is essential for DNA repair. Cell Cycle. 2007;6(3):318-329.

  31. Trzeciak AR, Barnes J, Evans MK. A modified alkaline comet assay for measuring DNA repair capacity in human populations. Radiat Res. 2008;169(1):110-121.

  32. Xiao L, Rao JN, Zou T, Liu L, Marasa BS, Chen J, Turner DJ, Zhou H, Gorospe M, Wang JY. Polyamines regulate the stability of activating transcription factor-2 mRNA through RNA-binding protein HuR in intestinal epithelial cells. Mol Biol Cell. 2007;18(11):4579-4590.

  33. Zahn JM, Poosala S, Owen AB, Ingram DK, Lustig A, Carter A, Weeraratna AT, Taub DD, Gorospe M, Mazan-Mamczarz K, Lakatta EG, Boheler KR, Xu X, Mattson MP, Falco G, Ko MS, Schlessinger D, Firman J, Kummerfeld SK, Wood WH, Zonderman AB, Kim SK, Becker KG. AGEMAP: A Gene Expression Database for Aging in Mice. PLoS Genet. 2007;3(11):e201.

  34. Zhu TN, He HJ, Kole S, D'Souza T, Agarwal R, Morin PJ, Bernier M. Filamin A-mediated down-regulation of the exchange factor Ras-GRF1 correlates with decreased matrix metalloproteinase-9 expression in human melanoma cells. J Biol Chem. 2007;282(20):14816-14826.

  35. Cunningham SC, Gallmeier E, Hucl T, Dezentje DA, Abdelmohsen K, Gorospe M, Kern SE. Theoretical proposal: allele dosage of MAP2K4/MKK4 could rationalize frequent 17p loss in diverse human cancers. Cell Cycle. 2006;5(10):1090-1093.

  36. Cunningham SC, Gallmeier E, Hucl T, Dezentje DA, Calhoun ES, Falco G, Abdelmohsen K, Gorospe M, Kern SE. Targeted deletion of MKK4 in cancer cells: a detrimental phenotype manifests as decreased experimental metastasis and suggests a counterweight to the evolution of tumor-suppressor loss. Cancer Res. 2006;66(11):5560-5564.

  37. Dang Y, Kedersha N, Low WK, Romo D, Gorospe M, Randal K, Anderson P, Liu JO. Eukaryotic initiation factor 2a independent pathway of stress granule induction by the natural product pateamine A. J Biol Chem. 2006;281(43):32870-32878.

  38. Fan J, Zhan M, Shen J, Martindale JL, Yang X, Kawai T, Gorospe M. En masse nascent transcription analysis to elucidate regulatory transcription factors. Nucleic Acids Res. 2006;34(5):1492-1500.

  39. Fugmann SD, Messier C, Novack LA, Cameron RA, Rast JP. An ancient evolutionary origin of the Rag1/2 gene locus. Proc Natl Acad Sci USA. 2006;103:3728-3733.

  40. Gallmeier E, Calhoun ES, Rago C, Brody JR, Cunningham SC, Hucl T, Gorospe M, Kohli M, Lengauer C, Kern SE. Targeted disruption of FANCC and FANCG in human cancer provides a preclinical model for specific therapeutic options. Gastroenterology. 2006;130(7):2145-2154.

  41. Hewitt KJ, Agarwal R, Morin PJ. The claudin gene family: expression in normal and neoplastic tissues. BMC Cancer. 2006;6:186.

  42. Hibino T, Loza-Coll M, Messier C, Majeske AJ, Cohen AH, Terwilliger DP, Buckley KM, Brockton V, Nair SV, Berney K, Fugmann SD, Anderson MK, Pancer Z, Cameron RA, Smith LC, Rast JP. The immune gene repertoire encoded in the purple sea urchin genome. Dev Biol. 2006;300(1):349-365.

  43. Hill JW, Evans MK. Dimerization and opposite base-dependent catalytic impairment of polymorphic S326C OGG1 glycosylase. Nucleic Acids Res. 2006;34(5):1620-1632.

  44. Honda H, Pazin MJ, Ji H, Wernyj RP, Morin PJ. Crucial roles of Sp1 and epigenetic modifications in the regulation of the CLDN4 promoter in ovarian cancer cells. J Biol Chem. 2006;281(30):21433-21444.

  45. Kawai T, Lal A, Yang X, Galban S, Mazan-Mamczarz K, Gorospe M. Translational control of cytochrome c by RNA-binding proteins TIA-1 and HuR. Mol Cell Biol. 2006;26(8):3295-3307.

  46. Lal A, Abdelmohsen K, Pullmann R, Kawai T, Galban S, Yang X, Brewer G, Gorospe M. Posttranscriptional derepression of GADD45a by genotoxic stress. Mol Cell. 2006;22(1):117-128.

  47. Lal A, Gorospe M. Egad, more forms of gene regulation: the gadd45a story. Cell Cycle. 2006 Jul;5(13):1422-1425.

  48. Mazan-Mamczarz K, Lal A, Martindale JL, Kawai T, Gorospe M. Translational repression by RNA-binding protein TIAR. Mol Cell Biol. 2006;26(7):2716-2727.

  49. Mittal A, Papa S, Franzoso G, Sen R. NF-kB-dependent regulation of the timing of activation-induced cell death of T lymphocytes. J Immunol. 2006;176(4):2183-2189.

  50. Nakayama K, Nakayama N, Davidson B, Sheu JJ, Jinawath N, Santillan A, Salani R, Bristow RE, Morin PJ, Kurman RJ, Wang TL, Shih IeM. A BTB/POZ protein, NAC-1, is related to tumor recurrence and is essential for tumor growth and survival. Proc Natl Acad Sci USA. 2006;103(49):18739-18744.

  51. Nyaga SG, Lohani A, Jaruga P, Trzeciak AR, Dizdaroglu M, Evans MK. Reduced repair of 8-hydroxyguanine in the human breast cancer cell line, HCC1937. BMC Cancer. 2006;6:297.

  52. Pullmann R Jr, Abdelmohsen K, Lal A, Martindale JL, Ladner RD, Gorospe M. Differential stability of thymidylate synthase 3'-untranslated Rregion polymorphic variants regulated by AUF1. J Biol Chem. 2006;281(33):23456-23463.

  53. Sea Urchin Genome Sequencing Consortium; (including Fugmann SD): The genome of the sea urchin Strongylocentrotus purpuratus. Science. 2006;314(5801):941-952.

  54. Sen R. Control of B lymphocyte apoptosis by the transcription factor NF-kappaB. Immunity. 2006;25(6):871-883.

  55. Sen R, Oltz E. Genetic and epigenetic regulation of IgH gene assembly. Curr Opin Immunol. 2006;18(3):237-242.

  56. Shogren-Knaak M, Ishii H, Sun JM, Pazin MJ, Davie JR, Peterson CL. Histone H4-K16 acetylation controls chromatin structure and protein interactions. Science. 2006;311(5762):844-847.

  57. Smith WW, Gorospe M, Kusiak JW. Signaling mechanisms underlying Abeta toxicity: potential therapeutic targets for Alzheimer's disease. CNS Neurol Disord Drug Targets. 2006;5(3):355-361.

  58. Tanaka TS, Lopez de Silanes I, Sharova LV, Akutsu H, Yoshikawa T, Amano H, Yamanaka S, Gorospe M, Ko MS. Esg1, expressed exclusively in preimplantation embryos, germline, and embryonic stem cells, is a putative RNA-binding protein with broad RNA targets. Dev Growth Differ. 2006;48(6):381-390.

  59. Zou T, Mazan-Mamczarz K, Rao JN, Liu L, Marasa BS, Zhang AH, Xiao L, Pullmann R, Gorospe M, Wang JY. Polyamine depletion increases cytoplasmic levels of RNA-binding protein HuR leading to stabilization of nucleophosmin and p53 mRNAs. J Biol Chem. 2006 ;281(28):19387-19394.

  60. Agarwal R, D'Souza T, Morin PJ. Claudin-3 and claudin-4 expression in ovarian epithelial cells enhances invasion and is associated with increased matrix metalloproteinase-2 activity. Cancer Res. 2005;65(16):7378-7385.

  61. Banerjee D, Liou HC, Sen R. c-Rel-Dependent priming of aaive T cells by inflammatory cytokines. Immunity. 2005;23(4):445-458.

  62. Cheadle C, Fan J, Cho-Chung YS, Werner T, Ray J, Do L, Gorospe M, Becker KG. Control of gene expression during T cell activation: alternate regulation of mRNA transcription and mRNA stability. BMC Genomics. 2005;6(1):75.

  63. Cheadle C, Fan J, Cho-Chung YS, Werner T, Ray J, Do L, Gorospe M, Becker KG. Stability regulation of mRNA and the control of gene expression. Ann NY Acad Sci. 2005;1058:196-204.

  64. Chen YC, Pohl G, Wang TL, Morin PJ, Risberg B, Kristensen GB, Yu A, Davidson B, Shih IM. Apolipoprotein E is required for cell proliferation and survival in ovarian cancer. Cancer Res. 2005;65(1):331-337.

  65. Dombroski D, Houghtling RA, Labno CM, Precht P, Takesono A, Caplen NJ, Billadeau DD, Wange RL, Burkhardt JK, Schwartzberg PL. Kinase-independent functions for Itk in TCR-induced regulation of Vav and the Actin cytoskeleton. J Immunol. 2005;174(3):1385-1392.

  66. D'Souza T, Agarwal R, Morin PJ. Phosphorylation of claudin-3 at threonine 192 by PKA regulates tight junction barrier function in ovarian cancer cells. J Biol Chem. 2005;280(28):26233-26240.

  67. Fan J, Heller NM, Gorospe M, Atasoy U, Stellato C. The role of post-transcriptional regulation in chemokine gene expression in inflammation and allergy. Eur Respir J. 2005;26(5):933-947.

  68. Gao P, Wange RL, Zhang N, Oppenheim JJ, Howard OM. Negative regulation of CXCR4-mediated chemotaxis by the lipid phosphatase activity of tumor suppressor PTEN. Blood. 2005;106(8):2619-2626.

  69. Huang Y, Norton DD, Precht P, Martindale JL, Burkhardt JK, Wange RL. Deficiency of ADAP/FYB/SLAP130 destabilizes SKAP55 in jurkat T cells. J Biol Chem. 2005;280(25):23576-23583.

  70. Huang Y, Wernyj RP, Norton DD, Precht P, Seminario MC, Wange RL. Modulation of specific protein expression levels by PTEN: identification of AKAP121, DHFR, G3BP, Rap1, and RCC1 as potential targets of PTEN. Oncogene. 2005;24(23):3819-3829.

  71. Lal A, Haynes SR, Gorospe M. Clean western blot signals from immunoprecipitated samples. Mol Cell Probes. 2005;19(6):385-388.

  72. Lal A, Kawai T, Yang X, Mazan-Mamczarz K, Gorospe M. Antiapoptotic function of RNA-binding protein HuR effected through prothymosin alpha. EMBO J. 2005;24(10):1852-1862.

  73. Lopez de Silanes I, Galban S, Martindale JL, Yang X, Mazan-Mamczarz K, Indig FE, Falco G, Zhan M, Gorospe M. Identification and functional outcome of mRNAs associated with TIA-1 ribonucleoprotein complexes. Mol. Cell Biol. 2005;25(21): 9520-9531.

  74. Mazan-Mamczarz K, Kawai T, Martindale JL, Gorospe M. En masse analysis of nascent translation using microarrays. Biotechniques. 2005;39(1):61-2, 64, 66-67.

  75. Morin PJ. Claudin proteins in human cancer: promising new targets for diagnosis and therapy. Cancer Res. 2005;65(21):9603-9606.

  76. Pullmann R Jr, Juhaszova M, Lopez de Silanes I, Kawai T, Mazan-Mamczarz K, Halushka MK, Gorospe M. Enhanced proliferation of cultured human vascular smooth muscle cells linked to increased function of RNA-binding protein HuR. J Biol Chem. 2005;280(24):22819-22826.

  77. Sen R. A move to exclude. Nat Immunol. 2005;6(2):128-130.

  78. Smith WW, Norton DD, Gorospe M, Jiang H, Nemoto S, Holbrook NJ, Finkel T, Kusiak JW. Phosphorylation of p66Shc and forkhead proteins mediates Ab toxicity. J Cell Biol. 2005;169(2):331-339.

  79. Sollers JJ 3rd, Merritt MM, Silver RA, Evans MK, Zonderman AB, Thayer JF. Understanding blood pressure variability: spectral indices as a function of gender and age. Biomed Sci Instrum. 2005;41:43-47.

  80. Wali A, Morin PJ, Hough CD, Lonardo F, Seya T, Carbone M, Pass HI. Identification of intelectin overexpression in malignant pleural mesothelioma by serial analysis of gene expression (SAGE). Lung Cancer. 2005;48(1):19-29.

  81. Wang W, Martindale JL, Yang X, Chrest FJ, Gorospe M. Increased stability of the p16 mRNA with replicative senescence. EMBO Rep. 2005;6(2):158-164.

  82. Chowdhury D, Sen R. Mechanisms for feedback inhibition of the immunoglobulin heavy chain locus. Curr Opin Immunol. 2004;16(2):235-240.

  83. Chowdhury D, Sen R. Regulation of immunoglobulin heavy-chain gene rearrangements. Immunol Rev. 2004;200:182-196.

  84. Cohen HY, Miller C, Bitterman KJ, Wall NR, Hekking B, Kessler B, Howitz KT, Gorospe M, De Cabo R, Sinclair DA. Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase. Science. 2004;305:390-392.

  85. Huang Y, Wange RL. T cell receptor signaling: Beyond complex complexes. J Biol Chem. 2004;279(28):28827-28830.

  86. Kawai T, Fan J, Mazan-Mamczarz K, Gorospe M. Global mRNA stabilization preferentially linked to translational repression during the endoplasmic reticulum stress response. Mol Cell Biol. 2004;24(15):6773-6787.

  87. Kruman II, Wersto RP, Cardozo-Pelaez F, Smilenov L, Chan SL, Chrest FJ, Emokpae R Jr, Gorospe M, Mattson MP. Cell cycle activation linked to neuronal cell death initiated by DNA damage. Neuron. 2004;41(4):549-561.

  88. Lal A, Mazan-Mamczarz K, Kawai T, Yang X, Martindale JL, Gorospe M. Concurrent versus individual binding of HuR and AUF1 to common labile target mRNAs. EMBO J. 2004;23(15):3092-3102.

  89. Lopez de Silanes I, Fan J, Galban CJ, Spencer RG, Becker KG, Gorospe M. Global analysis of HuR-regulated gene expression in colon cancer systems of reducing complexity. Gene Expr. 2004;12(1):49-59.

  90. Lopez de Silanes I, Olmo N, Turnay J, de Buitrago GG, Perez-Ramos P, Guzman-Aranguez A, Garcia-Diez M, Lecona E, Gorospe M, Lizarbe MA. Acquisition of resistance to butyrate enhances survival after stress and induces malignancy of human colon carcinoma cells. Cancer Res. 2004;64(13):4593-4600.

  91. Lopez de Silanes I, Zhan M, Lal A, Yang X, Gorospe M. Identification of a target RNA motif for RNA-binding protein HuR. Proc Natl Acad Sci USA. 2004;101(9):2987-2992.

  92. Rangel LB, Agarwal R, Sherman-Baust CA, de Mello-Coelho V, Pizer ES, Ji H, Taub DD, Morin PJ. Anomalous expression of the HLA-DR a and b chains in ovarian and other cancer. Cancer Biol Ther. 2004;3(10).

  93. Seminario MC, Precht P, Bunnell SC, Warren SE, Morris CM, Taub D, Wange RL. PTEN permits acute increases in D3-phosphoinositide levels following TCR stimulation but inhibits distal signaling events by reducing the basal activity of Akt. Eur J Immunol. 2004;34(11):3165-3175.

  94. Sen R. NF-kB and the Immunoglobulin k Gene Enhancer. J Exp Med. 2004;200(9):1099-1102.

  95. Trzeciak AR, Nyaga SG, Jaruga P, Lohani A, Dizdaroglu M, Evans MK. Cellular repair of oxidatively induced DNA base lesions is defective in prostate cancer cell lines, PC-3 and DU-145. Carcinogenesis. 2004;25(8):1359-1370.

  96. Wang W, Yang X, Kawai T, Lopez De Silanes I, Mazan-Mamczarz K, Chen P, Chook YM, Quensel C, Kohler M, Gorospe M. AMP-activated protein kinase-regulated phosphorylation and acetylation of importin a1: involvement in the nuclear import of RNA-binding protein HuR. J Biol Chem. 2004;279(46):48376-48388.

  97. Wange RL. TCR Signaling: Another Abl-Bodied Kinase Joins the Cascade. Curr Biol. 2004;14(14):R562-R564.

  98. Weeraratna AT, Becker D, Carr KM, Duray PH, Rosenblatt KP, Yang S, Chen Y, Bittner M, Strausberg RL, Riggins GJ, Wagner U, Kallioniemi OP, Trent JM, Morin PJ, Meltzer PS. Generation and analysis of melanoma SAGE libraries: SAGE advice on the melanoma transcriptome. Oncogene. 2004;23(12):2264-2274.

  99. Wernyj RP, Morin PJ. Molecular mechanisms of platinum resistance: still searching for the Achilles' heel. Drug Resist Updat. 2004;7(4-5):227-232.

  100. Yang X, Wang W, Fan J, Lal A, Yang D, Cheng H, Gorospe M. Prostaglandin A2-mediated stabilization of p21 mRNA through an ERK-dependent pathway requiring RNA-binding protein HuR. J Biol Chem. 2004;279(47):49298-49306.

  101. Ambrosino C, Mace G, Galban S, Fritsch C, Vintersten K, Black E, Gorospe M, Nebreda AR. Negative feedback regulation of MKK6 mRNA stability by p38alpha mitogen-activated protein kinase. Mol Cell Biol. 2003;23(1): 370-381.

  102. Atasoy U, Curry SL, Lopez de Silanes I, Shyu AB, Casolaro V, Gorospe M, Stellato C. Regulation of eotaxin gene expression by TNF-a and IL-4 through mRNA stabilization: involvement of the RNA-binding protein HuR. J Immunol. 2003;171(8):4369-4378.

  103. Buckhaults P, Zhang Z, Chen YC, Wang TL, St Croix B, Saha S, Bardelli A, Morin PJ, Polyak K, Hruban RH, Velculescu VE, Shih IeM. Identifying tumor origin using a gene expression-based classification map. Cancer Res. 2003;63(14):4144-4149.

  104. de Cabo R, Furer-Galban S, Anson RM, Gilman C, Gorospe M, Lane MA. An in vitro model of caloric restriction. Exp Gerontol. 2003;38(6):631-639.

  105. Evans MK, Zonderman AB, Johnson WR. C-reactive protein in the prediction of cardiovascular events. N Engl J Med. 2003;348(11): 1059-1061.

  106. Figueroa A, Cuadrado A, Fan J, Atasoy U, Muscat GE, Munoz-Canoves P, Gorospe M, Munoz A. Role of HuR in skeletal myogenesis through coordinate regulation of muscle differentiation genes. Mol Cell Biol. 2003;23(14):4991-5004.

  107. Galban S, Fan J, Martindale JL, Cheadle C, Hoffman B, Woods MP, Temeles G, Brieger J, Decker J, Gorospe M. von Hippel-Lindau protein-mediated repression of tumor necrosis factor alpha translation revealed through use of cDNA arrays. Mol Cell Biol. 2003;23(7): 2316-2328.

  108. Galban S, Martindale JL, Mazan-Mamczarz K, Lopez de Silanes I, Fan J, Wang W, Decker J, Gorospe M. Influence of the RNA-binding protein HuR in pVHL-regulated p53 expression in renal carcinoma cells. Mol Cell Biol. 2003;23(20):7083-7095.

  109. Gorospe M. HuR in the mammalian genotoxic response: Post-transcriptional multitasking. Cell Cycle. 2003;2(5):412-414.

  110. Ikeyama S, Kokkonen G, Martindale JL, Wang XT, Gorospe M, Holbrook NJ. Effects of aging and calorie restriction of Fischer 344 rats on hepatocellular response to proliferative signals. Exp Gerontol. 2003;38(4): 431-439.

  111. Ikeyama S, Wang XT, Li J, Podlutsky A, Martindale JL, Kokkonen G, Van Huizen R, Gorospe M, Holbrook NJ. Expression of the pro-apoptotic gene Gadd153/chop is elevated in liver with aging and sensitizes cells to oxidant injury. J Biol Chem. 2003;278(19): 16726-16731.

  112. Li J, Gorospe M, Barnes J, Liu Y. Tumor promoter arsenite stimulates histone H3 phosphoacetylation of proto-oncogenes c-fos and c-jun chromatin in human diploid fibroblasts. J Biol Chem. 2003;278(15): 13183-13191.

  113. Lopez de Silanes I, Fan J, Yang X, Zonderman AB, Potapova O, Pizer ES, Gorospe M. Role of the RNA-binding protein HuR in colon carcinogenesis. Oncogene. 2003;22(46):7146-7154.

  114. Mazan-Mamczarz K, Galban S, Lopez De Silanes I, Martindale JL, Atasoy U, Keene JD, Gorospe M. RNA-binding protein HuR enhances p53 translation in response to ultraviolet light irradiation. Proc Natl Acad Sci USA. 2003;100(14):8354-8359.

  115. Merritt MM, Sollers JJ 3rd, Evans MK, Zonderman AB, Thayer JF. Relationships among spectral measures of baroreflex sensitivity and indices of cardiac vagal control. Biomed Sci Instrum. 2003;39: 193-198.

  116. Morin PJ. Drug resistance and the microenvironment: nature and nurture. Drug Resist Updat. 2003;6(4):169-172.

  117. Morin PJ, Weeraratna AT. The APC tumor suppressor pathway. Methods Mol Biol. 2003;222: 21-40.

  118. Morin PJ, Weeraratna AT. Wnt signaling in human cancer. Cancer Treat Res. 2003;115: 169-187.

  119. Rangel LB, Agarwal R, D'Souza T, Pizer ES, Alo PL, Lancaster WD, Gregoire L, Schwartz DR, Cho KR, Morin PJ. Tight junction proteins claudin-3 and claudin-4 are frequently overexpressed in ovarian cancer but not in ovarian cystadenomas. Clin Cancer Res. 2003;9(7):2567-2575.

  120. Rangel LB, Sherman-Baust CA, Wernyj RP, Schwartz DR, Cho KR, Morin PJ. Characterization of novel human ovarian cancer-specific transcripts (HOSTs) identified by serial analysis of gene expression. Oncogene. 2003;22(46):7225-7232.

  121. Seminario MC, Precht P, Wersto RP, Gorospe M, Wange RL. PTEN expression in PTEN-null leukaemic T cell lines leads to reduced proliferation via slowed cell cycle progression. Oncogene. 2003;22(50):8195-8204.

  122. Seminario MC, Wange RL. Lipid phosphatases in the regulation of T cell activation: living up to their PTEN-tial. Immunol Rev. 2003;192: 80-97.

  123. Shack S, Wang XT, Kokkonen GC, Gorospe M, Longo DL, Holbrook NJ. Caveolin-induced activation of the phosphatidylinositol 3-kinase/Akt pathway increases arsenite cytotoxicity. Mol Cell Biol. 2003;23(7): 2407-2414.

  124. Sherman-Baust CA, Weeraratna AT, Rangel LB, Pizer ES, Cho KR, Schwartz DR, Shock T, Morin PJ. Remodeling of the extracellular matrix through overexpression of collagen VI contributes to cisplatin resistance in ovarian cancer cells. Cancer Cell. 2003;3(4): 377-386.

  125. Terracciano A, Merritt M, Zonderman AB, Evans MK. Personality traits and sex differences in emotion recognition among African Americans and Caucasians. Ann NY Acad Sci. 2003;1000:309-312.

  126. Thayer JF, Merritt MM, Sollers JJ 3rd, Zonderman AB, Evans MK, Yie S, Abernethy DR. Effect of angiotensin-converting enzyme insertion/deletion polymorphism DD genotype on high-frequency heart rate variability in African Americans. Am J Cardiol. 2003;92(12):1487-1490.

  127. Van Huizen R, Martindale JL, Gorospe M, Holbrook NJ. P58IPK, a novel ER stress-inducible protein and potential negative regulator of eIF2a signaling. J Biol Chem. 2003;278(18): 15558-15564.

  128. Wang W, Yang X, Lopez De Silanes I, Carling D, Gorospe M. Increased AMP: ATP ratio and AMP-activated kinase activity during cellular senescence linked to reduced HuR function. J Biol Chem. 2003;278(29):27016-27023.

  129. Wu S, Morin PJ, Maouyo D, Sears CL. Bacteroides fragilis enterotoxin induces c-Myc expression and cellular proliferation. Gastroenterology. 2003;124(2): 392-400.

  130. Yang YA, Morin PJ, Han WF, Chen T, Bornman DM, Gabrielson EW, Pizer ES. Regulation of fatty acid synthase expression in breast cancer by sterol regulatory element binding protein-1c. Exp Cell Res. 2003;282(2): 132-137.

  131. Boon K, Osorio EC, Greenhut SF, Schaefer CF, Shoemaker J, Polyak K, Morin PJ, Buetow KH, Strausberg RL, De Souza SJ, Riggins GJ. An anatomy of normal and malignant gene expression. Proc Natl Acad Sci USA. 2002;99(17): 11287-11292.

  132. Caldwell MC, Hough C, Furer S, Linehan WM, Morin PJ, Gorospe M. Serial analysis of gene expression in renal carcinoma cells reveals VHL-dependent sensitivity to TNF alpha cytotoxicity. Oncogene 2002;21: 929-936.

  133. Fan J, Yang X, Wang W, Wood WH 3rd, Becker KG, Gorospe M. Global analysis of stress-regulated mRNA turnover by using cDNA arrays. Proc Natl Acad Sci USA. 2002;99(16): 10611-10616.

  134. Ikeyama S, Kokkonen G, Shack S, Wang X, Holbrook NJ. Loss in oxidative stress tolerance with aging linked to reduced extracellular signal-regulated kinase and Akt kinase activities. FASEB J. 2002;16: 114-116.

  135. Li J, Chen P, Sinogeeva N, Gorospe M, Wersto RP, Chrest FJ, Barnes J, Liu Y. Arsenic trioxide promotes histone H3 phosphoacetylation at the chromatin of CASPASE-10 in acute promyelocytic Leukemia cells. J Biol Chem. 2002;277(51): 49504-49510.

  136. Mambo E, Nyaga SG, Bohr VA, Evans MK. Defective repair of 8-hydroxyguanine in mitochondria of MCF-7 and MDA-MB-468 human breast cancer cell lines. Cancer Res. 2002;62(5): 1349-1355.

  137. Martindale JL, Holbrook NJ. Cellular response to oxidative stress: signaling for suicide and survival. J Cell Physiol. 2002;192(1): 1-15.

  138. Milhavet O, Martindale JL, Camandola S, Chan SL, Gary DS, Cheng A, Holbrook NJ, Mattson MP. Involvement of Gadd153 in the pathogenic action of presenilin-1 mutations. J Neurochem. 2002;83(3): 673-681.

  139. Morin PJ. APC/b-catenin pathway. In: Encyclopedic Reference of Cancer. Manfred Schwab (Ed.) Springer-Verlag, Heidelberg, 2002, pp.70-73.

  140. Morin PJ. Renal cell carcinoma: taking care of business. Cancer Biol Ther. 2002;1(5): 537-538.

  141. Potapova O, Anisimov SV, Gorospe M, Dougherty RH, Gaarde WA, Boheler KR, Holbrook NJ. Targets of c-Jun NH(2)-terminal Kinase 2-mediated tumor growth regulation revealed by serial analysis of gene expression. Cancer Res. 2002;62(11): 3257-3263.

  142. Sawiris GP, Sherman-Baust CA, Becker KG, Cheadle C, Teichberg D, Morin PJ. Development of a highly specialized cDNA array for the study and diagnosis of epithelial ovarian cancer. Cancer Res. 2002;62(10): 2923-2928.

  143. Seminario MC, Wange RL. Signaling pathways of D3-phosphoinositude-binding kinases in T cells and their regulation by PTEN. Semin Immunol. 2002;14: 27-36.

  144. Wang W, Fan J, Yang X, Furer-Galban S, Lopez de Silanes I, von Kobbe C, Guo J, Georas SN, Foufelle F, Hardie DG, Carling D, Gorospe M. AMP-activated kinase regulates cytoplasmic HuR. Mol Cell Biol. 2002;22(10): 3425-3436.

  145. Wei W, Norton DD, Wang X, Kusiak JW. Abeta 17-42 in Alzheimer's disease activates JNK and caspase-8 leading to neuronal apoptosis. Brain. 2002;125(Pt 9): 2036-2043.

  146. Wei W, Wang X, Kusiak JW. Signaling events in amyloid beta-peptide-induced neuronal death and insulin-like growth factor I protection. J Biol Chem. 2002;277(20): 17649-17656.

  147. Yang YA, Han WF, Morin PJ, Chrest FJ, Pizer ES. Activation of fatty acid synthesis during neoplastic transformation: role of mitogen-activated protein kinase and phosphatidylinositol 3-kinase. Exp Cell Res. 2002;279(1): 80-90.

  148. Buschmann T, Potapova O, Bar-Shira A, Ivanov VN, Fuchs SY, Henderson S, Fried VA, Minamoto T, Alarcon-Vargas D, Pincus MR, Gaarde WA, Holbrook NJ, Shiloh Y, Ronai Z. Jun NH(2)-terminal kinase phosphorylation of p53 on Thr-81 is important stabilization and transcriptional activities in response to stress. Mol Cell Biol. 2001;21(8): 2743-2754.

  149. Chen P, Hutter D, Yang X, Gorospe M, Davis RJ, Liu Y. Discordance between the binding affinity of mitogen-activated protein kinase subfamily members for MKP-2 and their ability to catalytically activate the phosphatase. J Biol Chem. 2001;276: 29440-29449.

  150. Herndon TM, Shan X, Tsokos GC, Wange RL. Expression of ZAP-70 and SLP-76 is required for NF-kB activation in Jurkat T cells in response to engagement of CD3 and CD28. J Immunol. 2001;166: 5654-5664.

  151. Hough CD, Cho KR, Schwartz DS, Zonderman AB, Morin PJ. Coordinately up-regulated genes in ovarian cancer. Cancer Res. 2001;61: 3869-3876.

  152. Klotz LO, Holbrook N, Sies H. UVA and singlet oxygen as inducers of cutaneous signaling events. Curr Probl Dermatol. 2001;29: 95-113.

  153. Li JN, Gorospe M, Chrest FJ, Kumaravel TS, Evans MK, Han WF, Pizer ES. Pharmacological inhibition of fatty acid synthase activity produces both cytostatic and cytotoxic effects modulated by p53. Cancer Res. 2001;61(4): 1493-1499.

  154. Li J, Gorospe M, Hutter D, Barnes J, Keyse SM, Liu Y. Transcriptional induction of MKP-1 in response to stress is associated with histone H3 phosphorylation-acetylation. Mol Cell Biol. 2001;21: 8213-8224.

  155. Lin H, Morin PJ. A novel homozygous deletion at chromosomal band 6q27 in an ovarian cancer cell line delineates the position of a putative tumor suppressor gene. Cancer Lett. 2001; 173: 63-70.

  156. Ling P, Meyer CF, Redmond LP, Shui J-W, Davis B Rich RR, Wange RL, Tan T-H. Involvement of hematopoietic progenitor kinase 1 (HPK1) in T-cell receptor (TCR) signaling. J Biol Chem. 2001;276: 18908-18914.

  157. Liu A, Prenger MS, Norton DD, Mei L, Kusiak JW, Bai G. Nerve growth factor uses Ras/ERK and phosphatidylinositol 3-kinase cascades to up-regulate the N-methyl-D-aspartate receptor 1 promoter. J Biol Chem. 2001;276(48): 45372-45379.

  158. Klotz LO, Holbrook NJ, Sies H. UVA and singlet oxygen as inducers of cutaneous signalling events. Curr Probl Dermatol. 2001;29: 95-113.

  159. Kusiak JW, Lee LL, Zhao B. Expression of mutant amyloid precursor proteins decreases adhesion and delays differentiation of Hep-1 cells. Brain Res. 2001;896(1-2): 146-152.

  160. Luo JJ, Wallace MS, Hawver DB, Kusiak JW, Wallace WC. Characterization of the neurotrophic interaction between nerve growth factor and secreted alpha-amyloid precursor protein. J Neurosci Res. 2001;63(5): 410-420.

  161. McCullough KD, Martindale JL, Klotz LO, Aw TY, Holbrook N. Gadd153 sensitizes cells to endoplasmic reticulum stress by down-regulating Bcl2 and perturbing the cellular redox state. Mol Cell Biol. 2001;21(4): 1249-1259.

  162. Potapova O, Basu S, Mercola D, Holbrook NJ. Protective role for c-Jun in the cellular response to DNA damage. J Biol Chem. 2001;276: 28546-28553.

  163. Shan X, Balakir R, Criado G, Wood JS, Seminario MC, Madrenas J, Wange RL. ZAP-70-independent Ca2+ mobilization and ERK activation in Jurkat T cells in response to CD3 cross-linking. Mol Cell Biol. 2001;21: 7134-7149.

  164. Tong T, Fan W, Zhao H, Jin S, Fan F, Blanck P, Alomo I, Rajasekaran B, Liu Y, Holbrook NJ, Zhan Q. Involvement of the MAP kinase pathways in induction of GADD45 following UV radiation. Exp Cell Res. 2001;269(1): 64-72.

  165. Veri MC, DeBell KE, Seminario MC, DiBaldassarre A, Reischl I, Rawat R, Graham L, Noviello C, Rellahan BL, Miscia S, Wange RL, Bonvini E. Membrane microdomain-dependent regulation of tyrosine phosphorylation of phospholipase Cg-1 in T lymphocytes. Mol Cell Biol. 2001;21: 6939-6950.

  166. Wang W, Yang X, Cristofalo VJ, Holbrook NJ, Gorospe M. Loss of HuR is linked to reduced expression of proliferative genes during replicative sequence. Mol Cell Biol. 2001;21: 5889-5898.

  167. Wang X, McCullough KD, Wang XJ, Carpenter G, Holbrook NJ. Oxidative stress-induced PLC-g1 activation enhances cell survival. J Biol Chem. 2001;276: 28364-28371.

  168. Arrington ED, Caldwell MC, Kumaravel TS, Lohani A, Joshi A, Evans MK, Chen HT, Nussenzweig A, Holbrook NJ, Gorospe M. Enhanced sensitivity and long-term G2 arrest in hydrogen peroxide-treated Ku80-null cells are unrelated to DNA repair defects. Free Radic Biol Med. 2000;29(11): 1166-1176.

  169. Finkel T, Holbrook N. Oxidants, oxidative stress and the biology of ageing. Nature. 2000;408(6809): 239-247.

  170. Furlong MT, Morin PJ. Rare activation of the TCF/b-catenin pathway in ovarian cancer. Gynecol Oncol. 2000;77: 97-104.

  171. Hough CD, Sherman-Baust CA, Pizer ES, Montz FJ, Im DD, Rosenshein NB, Cho KR, Riggins GJ, Morin PJ. Large-scale serial analysis of gene expression reveals gene differentially expressed in ovarian cancer. Cancer Research. 2000;60(22): 6281-6287.

  172. Huang Y, Hutter D, Liu Y, Wang X, Sheikh MS, Chan AM, Holbrook N. Transforming growth factor-b 1 suppresses serum deprivation-induced death of A549 cells through differential effects on c-Jun and JNK activities. J Biol Chem. 2000;275(24): 18234-18242.

  173. Hutter D, Yo Y, Chen W, Liu P, Holbrook N, Roth GS, Liu Y. Age-related decline in Ras/ERK mitogen-activated protein kinase cascade is linked to a reduced association between Shc and EGF receptor. J Gerontol A Biol Sci Med Sci. 2000;55(3): B125-B134.

  174. Klotz LO, Schieke SM, Sies H, Holbrook N. Peroxynitrite activates the phosphoinositide 3-kinase/Akt pathway in human skin primary fibroblasts. Biochem J. 2000;352(Pt 1): 219-225.

  175. Lin H, Pizer ES, Morin PJ. A frequent deletion polymorphism on chromosome 22q13 identified by representational difference analysis of ovarian cancer. Genomics. 2000;69: 391-394.

  176. Lin S, Wang W, Wilson M, Yang X, Brewer,G, Holbrook NJ, Gorospe M. Down-regulation of cyclin D1 expression by prostaglandin A(2) is mediated by enhanced cyclin D1 mRNA turnover. Mol Cell Biol. 2000;20(21): 7903-7913.

  177. Potapova O, Gorospe M, Bost F, Dean NM, Gaarde WA, Mercola D, Holbrook NJ. c-Jun N-terminal kinase is essential for growth of human T98G glioblastoma cells. J Biol Chem. 2000;275(32): 24767-24775.

  178. Potapova O, Gorospe M, Dougherty RH, Dean NM, Gaarde WA, Holbrook NJ. Inhibition of c-Jun N-terminal kinase 2 expression suppresses growth and induces apoptosis of human tumor cells in a p53-dependent manner. Mol Cell Biol. 2000;20(5): 1713-1722.

  179. Sasaki CY, Lin HJ, Morin PJ, Longo DL. Truncation of the extracellular region abrogates cell contact but retains the growth-suppressive activity of E-cadherin. Cancer Research. 2000;60(24): 7057-7065.

  180. Shan X, Czar MJ, Bunnell SC, Liu P, Liu Y, Schwartzberg PL, Wange RL. Deficiency of PTEN in Jurkat T cells causes constitutive localization of Itk to the plasma membrane and hyperresponsiveness to CD3 stimulation. Mol Cell Biol. 2000;20: 6945-6957.

  181. Wange RL. LAT, the linker for activation of T cells: a bridge between T cell-specific and general signaling pathways. Sci STKE. 2000;2000(63): RE1.

  182. Wang W, Caldwell MC, Lin S, Furneaux H, Gorospe M. HuR regulates cyclin A and cyclin B1 mRNA stability during cell proliferation. EMBO J. 2000;19(10): 2340-2350.

  183. Wang W, Furneaux H, Cheng H, Caldwell MC, Hutter D, Liu Y, Holbrook N, Gorospe M. HuR regulates p21 mRNA stabilization by UV light. Mol Cell Biol. 2000;20: 760-769.

  184. Wang W, Martindale JL, Holbrook N. Requirement for ERK activation in cisplatin-induced apoptosis. J Biol Chem. 2000;275(50): 39435-39443.

  185. Wang X, McCullough KD, Franke TF, Holbrook N. Epidermal growth factor receptor-dependent Akt activation by oxidative stress enhances cell survival. J Biol Chem. 2000;275(19): 14624-14631.

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