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Myriam Gorospe, Ph.D.
  1. Gorospe, M. and C. Baglioni. Tumor necrosis factor increases stability of interleukin-1 mRNA by activating protein kinase C. Journal of Biological Chemistry 268:6214-6220 (1993) .[Abs]

  2. Gorospe, M. and C. Baglioni. Degradation of unstable interleukin-1 alpha mRNA in a rabbit reticulocyte cell-free system. Localization of an instability determinant to a cluster of AUUUA motifs. Journal of Biological Chemistry 269:11845-11851 (1994) .[Abs]

  3. Liu, Y., M. Gorospe, C. Yang and N.J. Holbrook. Role of mitogen-activated protein kinase phosphatase during the cellular response to genotoxic stress. Inhibition of c-Jun N-terminal kinase activity and AP-1-dependent gene activation. Journal of Biological Chemistry 270:8377-8380 (1995) .[Abs]

  4. Xu, Q., Y. Liu, M. Gorospe, R. Udelsman and N.J. Holbrook. Acute hypertension activates mitogen-activated protein kinases in aortic wall. Journal of Clinical Investigation. 97:508-514 (1996) .[Abs]

  5. Liu, Y., J.L. Martindale, M. Gorospe and N.J. Holbrook. Regulation of p21WAF1/CIP1 expression through mitogen-activated protein kinase signaling pathway. Cancer Research 56:1-5 (1996) .[Abs]

  6. Gorospe, M., Y. Liu, Q. Xu, F.J. Chrest and N.J. Holbrook. Inhibition of G1 cyclin-dependent kinase activity during growth arrest of human breast carcinoma cells by prostaglandin A2. Molecular and Cellular Biology 16: 762-770 (1996) .[Abs]

  7. Liu, Y., K.Z. Guyton, M. Gorospe, Q. Xu, G.C. Kokkonen, Y.D. Mock, G.S. Roth and N.J. Holbrook. Age-related decline in MAP kinase activity in EGF-stimulated Rat hepatocytes. Journal of Biological Chemistry. 271:3604-3607 (1996) .[Abs]

  8. Gorospe, M. and N.J. Holbrook. Role of p21 in prostaglandin A2-mediated growth arrest versus death. Cancer Research 56:475-479 (1996) .
  9. Guyton, K.Z., Y. Liu, M. Gorospe, Q. Xu and N. J. Holbrook. Activation of mitogen-activated protein kinase by H2O2: Role in cell survival following oxidant injury. Journal of Biological Chemistry 271:4138-4142 (1996) .[Abs]

  10. Yang, C., M. Gorospe, J. Chang and A. Passaniti. Protein tyrosine phosphatase regulation of endothelial cell apoptosis and differentiation. Cell Growth and Differentiation 7: 161-171 (1996) .[Abs]

  11. Gorospe, M., J.L. Martindale, M.S. Sheikh, A.J. Fornace Jr, and N.J. Holbrook. Regulation of p21CIP1/WAF1 expression by cellular stress: p53-dependent and p53-independent mechanisms. Molecular and Cellular Differentiation 4:47-65 (1996).

  12. Liu, Y., K.Z. Guyton, M. Gorospe, Q. Xu and N.J. Holbrook. Differential activation of ERK, JNK/SAPK and p38/CSBP/RK MAP kinase family members during the cellular response to arsenite. Free Radicals in Biology and Medicine 21:771-781 (1996) .[Abs]

  13. Guyton, K.Z., M. Gorospe, T.W. Kensler and N.J. Holbrook. MAP Kinase activation by butylated hydroxytoluene hydroperoxide: implications for cellular survival and tumor promotion. Cancer Research 56:3480-3485 (1996) .[Abs]

  14. Gorospe, M., X. Wang, K.Z. Guyton and N.J. Holbrook. Protective role of p21Waf1/Cip1 against PGA2-mediated apoptosis of human colorectal carcinoma cells. Molecular and Cellular Biology 16:6654-6660 (1996) .
  15. Gorospe, M., S. Shack, K.Z. Guyton, D. Samid, and N.J. Holbrook. Upregulation and functional role of p21Waf1/Cip1 during growth arrest of human breast carcinoma MCF-7 cells by phenylacetate. Cell Growth and Differentiation 7:1609-1615 (1996) .[Abs]

  16. Gorospe, M., C. Cirielli, X. Wang, M. Capogrossi, and N.J. Holbrook. p21Waf1/Cip1 expression prevents p53-mediated apoptotic cell death of human melanoma cells. Oncogene14:929-935 (1997) .
  17. Wang, X., M. Gorospe, Y. Huang and N.J. Holbrook. p27Kip1 overexpression causes apoptotic death in mammalian cells. Oncogene 15:2991-2999 (1997). [Abs]

  18. Xu, Q., M. Gorospe, K.Z. Guyton, Y. Liu and N.J. Holbrook. Induction of mitogen-activated protein kinase phosphatase (MKP-1) during acute hypertension. Hypertension 30:106-111 (1997). [Abs]

  19. Guyton, K. Z., M. Gorospe, Y. Mock, G. C. Kokkonen, G. S. Roth and Nikki J. Holbrook. Age-related changes in activation of signal transduction cascades by oxidative stress. J. Investigative Dermatology 3(1):23-27 (1998) .[Abs]

  20. Gorospe, M., X. Wang and N.J. Holbrook. p53-dependent elevation of p21Waf1 expression by UV light is mediated through mRNA stabilization and involves a vanadate-sensitive regulatory system. Molecular and Cellular Biology 18(3):1400-1407 (1998) .[Abs]

  21. Liu, Y., M. Gorospe, G.C. Kokkonen, M.O. Boluyt, A. Younes, Y.D. Mock, X. Wang, G.S. Roth, and N.J. Holbrook. Impairment in p70 S6 kinase signaling pathway contributes to the decline in the proliferative capacity of aged hepatocytes. Exp. Cell Res. 240(1):40-48 (1998) .
  22. Gorospe, M., Egan, J.M., Zbar, B., Lerman, M., Geil, L., Kuzmin, I., Holbrook, N.J.: Protective function of von hippel-lindau protein against impaired protein processing in renal carcinoma cells. Mol. Cell. Biol., 19: 1289-1300 (1999).[Abs]

  23. He, H., Wang, X., Gorospe, M., Holbrook, N.J., and Trush, M.A.: Phorbol ester-induced mononuclear cell differentiation is blocked by the mitogen-activated protein kinase (MEK) inhibitor PD98059. Cell Growth Differ., 10: 307-315 (1999). [Abs]

  24. Gorospe, M., Wang, X., and Holbrook, N.J.: Functional role of p21 during the cellular response to stress. Gene Expr., 7(4-6): 377-385 (1999). [Abs]

  25. Wang, X., Gorospe, M., and Holbrook, N.J.: Gadd45 is not required for activation of c-June N-terminal kinase or p38 during acute stress. J. Biol. Chem., 274: 29599-29602 (1999). [Abs]

  26. Shack, S., Gorospe, M., Fawcett, T.W., Hudgins, W.R., and Holbrook, N.J.: Activation of the cholesterol pathway and ras maturation in response to stress. Oncogene, 18(44): 6021-6028 (1999). [Abs]

  27. Wang, W., Furneaux, H., Cheng, H., Caldwell, M.C., Hutter, D., Liu, Y., Holbrook, N., Gorospe, M.: HuR regulates p21 mRNA stabilization by UV light. Mol. Cell. Biol., 20: 760-769, 2000. [Abs]

  28. Wang, W., Caldwell, M.C., Lin, S., Furneaux, H., Gorospe, M.: HuR regulates cyclin A and cyclin B1 mRNA stability during cell proliferation. EMBO J., 19: 2340-2350, 2000. [Abs]

  29. Potapova, O., Gorospe, M., Dougherty, R.H., Dean, N.M., Gaarde, W.A., Holbrook, N.J.: Inhibition of c-Jun N-terminal kinase 2 expression suppresses growth and induces apoptosis of human tumor cells in a p53-dependent manner. Mol. Cell. Biol., 20(5): 1713-1722, 2000. [Abs]

  30. Potapova, O., Gorospe, M., Bost, F., Dean, N.M., Gaarde, W.A., Mercola, D., Holbrook, N.J.: c-Jun N-terminal kinase is essential for growth of human T98G glioblastoma cells. J. Biol. Chem., 275(32): 24767-24775, 2000. [Abs]

  31. Lin, S., Wang, W., Wilson, G.M., Yang, X., Brewer, G., Holbrook, N.J., Gorospe, M.: Down-regulation of cyclin D1 expression by prostaglandin A(2) is mediated by enhanced cyclin D1 mRNA turnover. Mol. Cell. Biol., 20(21): 7903-7913, 2000. [Abs]

  32. Arrington, E.D., Caldwell, M.C., Kumaravel, T.S., Lohani, A., Joshi, A., Evans, M.K., Chen, H.T., Nussenzweig, A., Holbrook, N.J., Gorospe, M.: Enhanced sensitivity and long-term G2 arrest in hydrogen peroxide-treated Ku80-null cells are unrelated to DNA repair defects. Free Radic. Biol. Med., 29(11): 1166-1176, 2000. [Abs]

  33. Li, J.N., Gorospe, M., Chrest, F.J., Kumaravel, T.S., Evans, M.K., Han, W.F., Pizer, E.S.: Pharmacological inhibition of fatty acid synthase activity produces both cytostatic and cytotoxic effects modulated by p53. Cancer Res. 61(4): 1493-1499, 2001. [Abs]

  34. Chen, P., Hutter, D., Yang, X., Gorospe, M., Davis, R.J., Liu, Y.: Discordance between the binding affinity of mitogen-activated protein kinase subfamily members for MAP kinase phosphatase-2 and their ability to activate the phosphatase catalytically. J. Biol. Chem. 276(31): 29440-29449, 2001. [Abs]

  35. Wang, W., Yang, X., Cristofalo, V.J., Holbrook, N.J., Gorospe, M.: Loss of HuR is linked to reduced expression of proliferative genes during replicative senescence. Mol. Cell Biol. 21(17): 5889-5898, 2001. [Abs]

  36. Li, J., Gorospe, M., Hutter, D., Barnes, J., Keyse, S.M., Liu, Y.: Transcriptional induction of MKP-1 in response to stress is associated with histone H3 phosphorylation-acetylation. Mol. Cell Biol. 21(23): 8213-8224, 2001. [Abs]

  37. Caldwell, M.C., Hough, C., Furer, S., Linehan, W.M., Morin, P.J., Gorospe, M.: Serial analysis of gene expression in renal carcinoma cells reveals VHL-dependent sensitivity to TNFalpha cytotoxicity. Oncogene. 21(6): 929-936, 2002. [Abs]

  38. Wang, W., Fan, J., Yang, X., Furer-Galban, S., Lopez de Silanes, I., von Kobbe, C., Guo, J., Georas, S.N., Foufelle, F., Hardie, D.G., Carling, D., Gorospe, M.: AMP-activated kinase regulates cytoplasmic HuR. Mol. Cell Biol. 22(10): 3425-3436, 2002. [Abs]

  39. Potapova, O., Anisimov, S.V., Gorospe, M., Dougherty, R.H., Gaarde, W.A., Boheler, K.R., Holbrook, N.J.: Targets of c-Jun NH(2)-terminal kinase 2-mediated tumor growth regulation revealed by serial analysis of gene expression. Cancer Res. 62(11): 3257-3263, 2002. [Abs]

  40. Fan, J., Yang, X., Wang, W., Wood, W.H. 3rd, Becker, K.G., Gorospe, M.: Global analysis of stress-regulated mRNA turnover by using cDNA arrays. Proc. Natl. Acad. Sci. USA. 99(16): 10611-10616, 2002. [Abs]

  41. Li, J., Chen, P., Sinogeeva, N., Gorospe, M., Wersto, R.P., Chrest, F.J., Barnes, J., Liu, Y.: Arsenic trioxide promotes histone H3 phosphoacetylation at the chromatin of CASPASE-10 in acute promyelocytic leukemia cells. J. Biol. Chem. 277(51): 49504-49510, 2002. [Abs]

  42. Ambrosino, C., Mace, G., Galban, S., Fritsch, C., Vintersten, K., Black, E., Gorospe, M., Nebreda, A.R.: Negative feedback regulation of MKK6 mRNA stability by p38alpha mitogen-activated protein kinase. Mol. Cell Biol. 23(1): 370-381, 2003. [Abs]

  43. Li, J., Gorospe, M., Barnes, J., Liu, Y.: Tumor promoter arsenite stimulates histone H3 phosphoacetylation of proto-oncogenes c-fos and c-jun chromatin in human Diploid fibroblasts. J. Biol. Chem. 278(15): 13183-13191, 2003. [Abs]

  44. Van Huizen, R., Martindale, J.L., Gorospe, M., Holbrook, N.J.: P58IPK, a novel ER stress-inducible protein and potential negative regulator of eIF2a signaling. J. Biol. Chem. 278(18): 15558-15564, 2003. [Abs]

  45. Ikeyama, S., Wang, X.T., Li, J., Podlutsky, A., Martindale, J.L., Kokkonen, G., Van Huizen, R., Gorospe, M., Holbrook, N.J.: Expression of the pro-apoptotic gene gadd153/chop is elevated in liver with aging and sensitizes cells to oxidant injury. J. Biol. Chem. 278(19): 16726-16731, 2003. [Abs]

  46. Galban, S., Fan, J., Martindale, J.L., Cheadle, C., Hoffman, B., Woods, M.P., Temeles, G., Brieger, J., Decker, J., Gorospe, M..: von Hippel-Lindau protein-mediated repression of tumor necrosis factor alpha translation revealed through use of cDNA arrays. Mol. Cell Biol. 23(7): 2316-2328, 2003. [Abs]

  47. Shack, S., Wang, X.T., Kokkonen, G.C., Gorospe, M., Longo, D.L., Holbrook, N.J.: Caveolin-induced activation of the phosphatidylinositol 3-kinase/Akt pathway increases arsenite cytotoxicity. Mol. Cell Biol. 23(7): 2407-2414, 2003. [Abs]

  48. Ikeyama, S., Kokkonen, G., Martindale, J.L., Wang, X.T., Gorospe, M., Holbrook, N.J.: Effects of aging and calorie restriction of Fischer 344 rats on hepatocellular response to proliferative signals. Exp. Gerontol. 38(4): 431-439, 2003. [Abs]

  49. de Cabo, R., Furer-Galban, S., Anson, R.M., Gilman, C., Gorospe, M., Lane, M.A.: An in vitro model of caloric restriction. Exp. Gerontol. 38(6): 631-639, 2003. [Abs]

  50. Wang, W., Yang, X., Lopez De Silanes, I., Carling, D., Gorospe, M.: Increased AMP:ATP ratio and AMP-activated kinease activity during cellular senescence linked to reduced HuR function. J. Biol. Chem. 278(29): 27016-27023, 2003. [Abs]

  51. Mazan-Mamczarz, K., Galban, S., Lopez De Silanes, I., Martindale, J.L., Atasoy, U., Keene, J.D., Gorospe, M.: RNA-binding protein HuR enhances p53 translation in response to ultraviolet light irradiation. Proc. Natl. Acad. Sci. USA 100(14): 8354-8359, 2003. [Abs]

  52. Figueroa, A., Cuadrado, Fan, J., Atasoy, U., Muscat, G.E., Munoz-Canoves, P., Gorospe, M., Munoz, A.: Role of HuR in skeletal myogenesis through coordinate regulation of muscle differentiation genes. Mol. Cell. Biol. 23(14): 4991-5004, 2003. [Abs]

  53. Gorospe, M.: HuR in the mammalian genotoxic response: post-transcriptional multitasking. Cell Cycle. 2(5): 412-414, 2003. [Link]

  54. Galban, S., Martindale, J.L., Mazan-Mamczarz, K., Lopez de Silanes, I., Fan, J., Wang, W., Decker, J., Gorospe, M.: Influence of the RNA-binding protein HuR in pVHL-regulated p53 expression in renal carcinoma cells. Mol. Cell Biol. 23(20): 7083-7095, 2003. [Abs]

  55. Atasoy, U., Curry, S.L., Lopez de Silanes, I., Shyu, A.B., Casolaro, V., Gorospe, M., Stellato, C.: Regulation of eotaxin gene expression by TNF-a and IL-4 through mRNA stabilization: involvement of the RNA-binding protein HuR. J. Immunol. 171(8): 4369-4378, 2003. [Abs]

  56. Lopez de Silanes, I., Fan, J., Yang, X., Zonderman, A.B., Potapova, O., Pizer, E.S., Gorospe, M.: Role of the RNA-binding protein HuR in colon carcinogenesis. Oncogene. 22(46): 7146-7154, 2003. [Abs]

  57. Seminaro, M.C., Precht, P., Wersto, R.P., Gorospe, M., Wange, R.L.: PTEN expression in PTEN-null leukaemic T cell lines leads to reduced proliferation via slowed cell cycle progression.. Oncogene. 22(50): 8195-8204, 2003. [Abs]

  58. Kruman, I.I., Wersto, R.P., Cardozo-Pelaez, F., Smilenov, L., Chan, S.L., Chrest, F.J., Emokpae, R., Jr., Gorospe, M., Mattson, M.P.: Cell cycle activation linked to neuronal cell death initiated by DNA damage. Neuron. 41(4): 549-561, 2004. [Abs]

  59. Lopez de Silanes, I., Zhan, M., Lal, A., Yang, X., Gorospe, M.: Identification of a target RNA motif for RNA-binding protein HuR. Proc. Natl. Acad. Sci. USA 101(9): 2987-2992, 2004. [Abs]

  60. Cohen, H.Y., Miller, C., Bitterman, K.J., Wall, N.R., Hekking, B., Kessler, B., Howitz, K.T., Gorospe, M., de Cabo, R., Sinclair, D.A.: Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase. Science. 305: 390-392, 2004. [Abs]

  61. Kawai, T., Fan, J., Mazan-Mamczarz, K., Gorospe, M.: Global mRNA stabilization preferentially linked to translational repression during the endoplasmic reticulum stress response. Mol Cell Biol. 24(15): 6773-6787, 2004. [Abs]

  62. Lal, A., Mazan-Mamczarz, K., Kawai, T., Yang, X., Martindale, J.L., Gorospe, M.: Concurrent versus individual binding of HuR and AUF1 to common labile target mRNAs. EMBO J. 23(15): 3092-3102, 2004. [Abs]

  63. Lopez de Silanes, I., Fan, J., Galban, C.J., Spencer, R.G., Becker, K.G., Gorospe, M.: Global analysis of HuR-regulated gene expression in colon cancer systems of reducing complexity. Gene Expr. 12(1): 49-59, 2004. [Abs]

  64. Lopez de Silanes, I., Olmo, N., Turnay, J., de Buitrago, G.G., Perez-Ramos, P., Guzman-Aranguez, A., Garcia-Diez, M., Lecona, E., Gorospe, M., Lizarbe, M.A.: Acquisition of resistance to butyrate enhances survival after stress and induces malignancy of human colon carcinoma cells. Cancer Res. 64(13): 4593-4600, 2004. [Abs]

  65. Wang, W., Yang, X., Kawai, T., Lopez De Silanes, I., Mazan-Mamczarz, K., Chen, P., Chook, Y.M., Quensel, C., Kohler, M., Gorospe, M.: AMP-activated protein kinase-regulated phosphorylation and acetylation of importin a1: involvement in the nuclear import of RNA-binding protein HuR. J Biol Chem. 279(46): 48376-48388, 2004. [Abs]

  66. Yang, X., Wang, W., Fan, J., Lal, A., Yang, D., Cheng, H., Gorospe, M.: Prostaglandin A2-mediated stabilization of p21 mRNA through an ERK-dependent pathway requiring RNA-binding protein HuR. J Biol Chem. 279(47): 49298-49306, 2004. [Abs]

  67. Cheadle C, Fan J, Cho-Chung YS, Werner T, Ray J, Do L, Gorospe M, Becker KG. Control of gene expression during T cell activation: alternate regulation of mRNA transcription and mRNA stability. BMC Genomics. 6(1):75, 2005.[Abs]

  68. Cheadle C, Fan J, Cho-Chung YS, Werner T, Ray J, Do L, Gorospe M, Becker KG. Stability regulation of mRNA and the control of gene expression. Ann NY Acad Sci. 1058:196-204, 2005.[Abs]

  69. Fan J, Heller NM, Gorospe M, Atasoy U, Stellato C. The role of post-transcriptional regulation in chemokine gene expression in inflammation and allergy. Eur Respir J. 26(5):933-947, 2005.[Abs]

  70. Lal A, Haynes SR, Gorospe M. Clean western blot signals from immunoprecipitated samples. Mol Cell Probes. 19(6):385-388, 2005.[Abs]

  71. Lal A, Kawai T, Yang X, Mazan-Mamczarz K, Gorospe M. Antiapoptotic function of RNA-binding protein HuR effected through prothymosin alpha. EMBO J. 24(10):1852-1862, 2005.[Abs]

  72. Lopez de Silanes I, Galban S, Martindale JL, Yang X, Mazan-Mamczarz K, Indig FE, Falco G, Zhan M, Gorospe M. Identification and functional outcome of mRNAs associated with TIA-1 ribonucleoprotein complexes. Mol. Cell Biol. 25(21): 9520-9531, 2005.

  73. Mazan-Mamczarz K, Kawai T, Martindale JL, Gorospe M. En masse analysis of nascent translation using microarrays. Biotechniques. 39(1):61-2, 64, 66-67, 2005.[Abs]

  74. Pullmann R Jr, Juhaszova M, Lopez de Silanes I, Kawai T, Mazan-Mamczarz K, Halushka MK, Gorospe M. Enhanced proliferation of cultured human vascular smooth muscle cells linked to increased function of RNA-binding protein HuR. J Biol Chem. 280(24):22819-22826, 2005.[Abs]

  75. Smith WW, Norton DD, Gorospe M, Jiang H, Nemoto S, Holbrook NJ, Finkel T, Kusiak JW. Phosphorylation of p66Shc and forkhead proteins mediates Ab toxicity. J Cell Biol. 169(2):331-339, 2005.

  76. Wang W, Martindale JL, Yang X, Chrest FJ, Gorospe M. Increased stability of the p16 mRNA with replicative senescence. EMBO Rep. 6(2):158-164, 2005.[Abs]

  77. Cunningham SC, Gallmeier E, Hucl T, Dezentje DA, Abdelmohsen K, Gorospe M, Kern SE. Theoretical proposal: allele dosage of MAP2K4/MKK4 could rationalize frequent 17p loss in diverse human cancers. Cell Cycle. 5(10):1090-1093. 2006.[Abs]

  78. Cunningham SC, Gallmeier E, Hucl T, Dezentje DA, Calhoun ES, Falco G, Abdelmohsen K, Gorospe M, Kern SE. Targeted deletion of MKK4 in cancer cells: a detrimental phenotype manifests as decreased experimental metastasis and suggests a counterweight to the evolution of tumor-suppressor loss. Cancer Res. 66(11):5560-5564, 2006.[Abs]

  79. Dang Y, Kedersha N, Low WK, Romo D, Gorospe M, Randal K, Anderson P, Liu JO. Eukaryotic initiation factor 2a independent pathway of stress granule induction by the natural product pateamine A. J Biol Chem. 281(43):32870-32878, 2006.

  80. Fan J, Zhan M, Shen J, Martindale JL, Yang X, Kawai T, Gorospe M. En masse nascent transcription analysis to elucidate regulatory transcription factors. Nucleic Acids Res. 34(5):1492-1500, 2006.[Abs]

  81. Gallmeier E, Calhoun ES, Rago C, Brody JR, Cunningham SC, Hucl T, Gorospe M, Kohli M, Lengauer C, Kern SE. Targeted disruption of FANCC and FANCG in human cancer provides a preclinical model for specific therapeutic options. Gastroenterology. 130(7):2145-2154, 2006.[Abs]

  82. Kawai T, Lal A, Yang X, Galban S, Mazan-Mamczarz K, Gorospe M. Translational control of cytochrome c by RNA-binding proteins TIA-1 and HuR. Mol Cell Biol. 26(8):3295-3307, 2006.[Abs]

  83. Lal A, Abdelmohsen K, Pullmann R, Kawai T, Galban S, Yang X, Brewer G, Gorospe M. Posttranscriptional derepression of GADD45a by genotoxic stress. Mol Cell. 22(1):117-128, 2006.[Abs]

  84. Lal A, Gorospe M. Egad, more forms of gene regulation: the gadd45a story. Cell Cycle. 5(13):1422-1425, 2006.[Abs]

  85. Mazan-Mamczarz K, Lal A, Martindale JL, Kawai T, Gorospe M. Translational repression by RNA-binding protein TIAR. Mol Cell Biol. 26(7):2716-2727, 2006.[Abs]

  86. Pullmann R Jr, Abdelmohsen K, Lal A, Martindale JL, Ladner RD, Gorospe M. Differential stability of thymidylate synthase 3'-untranslated Rregion polymorphic variants regulated by AUF1. J Biol Chem. 281(33):23456-23463, 2006.[Abs]

  87. Smith WW, Gorospe M, Kusiak JW. Signaling mechanisms underlying Abeta toxicity: potential therapeutic targets for Alzheimer's disease. CNS Neurol Disord Drug Targets. 5(3):355-361, 2006.[Abs]

  88. Tanaka TS, Lopez de Silanes I, Sharova LV, Akutsu H, Yoshikawa T, Amano H, Yamanaka S, Gorospe M, Ko MS. Esg1, expressed exclusively in preimplantation embryos, germline, and embryonic stem cells, is a putative RNA-binding protein with broad RNA targets. Dev Growth Differ. 48(6):381-390, 2006.[Abs]

  89. Zou T, Mazan-Mamczarz K, Rao JN, Liu L, Marasa BS, Zhang AH, Xiao L, Pullmann R, Gorospe M, Wang JY. Polyamine depletion increases cytoplasmic levels of RNA-binding protein HuR leading to stabilization of nucleophosmin and p53 mRNAs. J Biol Chem. 281(28):19387-19394, 2006.[Abs]

  90. Abdelmohsen K, Lal A, Kim HH, Gorospe M. Posttranscriptional orchestration of an anti-apoptotic program by HuR. Cell Cycle. 6(11):1288-1292, 2007.[Abs]

  91. Abdelmohsen K, Pullmann R Jr, Lal A, Kim HH, Galban S, Yang X, Blethrow JD, Walker M, Shubert J, Gillespie DA, Furneaux H, Gorospe M. Phosphorylation of HuR by Chk2 regulates SIRT1 expression. Mol Cell. 25(4):543-557, 2007.[Abs]
  92. Kim HS, Kuwano Y, Zhan M, Pullmann R Jr, Mazan-Mamczarz K, Li H, Kedersha N, Anderson P, Wilce MC, Gorospe M, Wilce JA. Elucidation of a C-rich signature motif in target mRNAs of RNA-binding protein TIAR. Mol Cell Biol.27(19):6806-17. 2007.[Abs]

  93. Pullmann R Jr, Kim HH, Abdelmohsen K, Lal A, Martindale JL, Yang X, Gorospe M. Analysis of turnover and translation regulatory RBP expression through binding to cognate mRNAs. Mol Cell Biol. 27(18):6265-6278, 2007.[Abs]
  94. Schwartz EI, Smilenov LB, Price MA, Osredkar T, Baker RA, Ghosh S, Shi FD, Vollmer TL, Lencinas A, Stearns DM, Gorospe M, Kruman II. Cell cycle activation in postmitotic neurons is essential for DNA repair. Cell Cycle. 6(3):318-329, 2007.[Abs]

  95. Xiao L, Rao JN, Zou T, Liu L, Marasa BS, Chen J, Turner DJ, Zhou H, Gorospe M, Wang JY. Polyamines regulate the stability of activating transcription factor-2 mRNA through RNA-binding protein HuR in intestinal epithelial cells. Mol Biol Cell.18(11):4579-90. 2007.[Abs]

  96. Zahn, J.M., Poosala, S., Owen, A.B., Ingram, D., Lustig, A., Carter, A., Weeraratna, A.T., Taub, D.D., Gorospe, M., Mazan-Mamczarz, K., Lakatta, E., Boheler, K.R., Xu, X., Mattson, M.P., Falco, G., Ko, M.S.H., Schlessinger, D., Firman, J., Kummerfeld, S.K., Wood, W., Zonderman, A.B., Kim, S. K., Becker, K.G.  AGEMAP: a gene expression database for aging in mice.  PloS Genetics, 3(11):e201, 2007.[Abs]

  97. Lecona, E., Olmo, N., Turnay, J., Santiago-Gomez, A., Lopez de Silanes, I., Gorospe, M., and Lizarbe, M.A. Kinetic analysis of butyrate transport in human colon adenocarcinoma cells reveals two different carrier-mediated mechanisms.  Biochem. J. 409: 311-20, 2008.[Abs]

  98. Zou, T., Liu, L., Rao, J.N., Marasa, B.S., Chen, J., Xiao, L., Zhou, H., Gorospe, M., Wang, J.-Y. Polyamines Modulate the Subcellular Localization of RNA-binding Protein HuR through AMP-activated Protein Kinase-regulated Phosphorylation and Acetylation of Importin α1.  Biochemical J.  409: 389-98, 2008.[Abs]

  99. Galbán, S., Kuwano, Y., Pullmann, R. Jr., Martindale, J.L., Kim, H.H., Lal, A., Abdelmohsen, K., Yang, X., Dang, Y., Liu, J.O.,  Lewis, S.M., Holcik, M., and Gorospe, M. RNA-binding proteins HuR and PTB promote the translation of hypoxia-inducible factor 1α. Mol. Cell. Biol. 28: 93-107, 2008.[Abs]

  100. Abdelmohsen, K., Kuwano, Y., Kim, H.H., Gorospe, M.  Posttranscriptional Gene Regulation by RNA-Binding Proteins During Oxidative Stress:  Implications for Cellular Senescence.  Biol. Chem. 389: 243-55, 2008.[Abs]

  101. M. Gorospe and R. de Cabo; AsSIRTing the DNA damage response.  Trends in Cell Biology 18: 77-83, 2008.[Abs]

  102. Casolaro, V., Srikantan, R.S., Gorospe, M., and Stellato, C. Posttranscriptional Regulation of IL-13 in T Cells: Role of the RNA-binding protein HuR.  Journal of Allergy and Clinical Immunology 121: 853-9, 2008.[Abs]

  103. Robinson, V.L., Shalhav, O., Otto, K., Kawai, T., Gorospe, M., and Rinker-Schaeffer, C.W. MAP kinase kinase 4 (MKK4) protein expression is subject to translational regulation in prostate cancer cell lines. Mol. Cancer Res. 6: 501-8, 2008.[Abs]

  104. Lal. A., Kim H. H., Abdelmohsen, K., Kuwano, Y., Pullmann, R., Jr., Srikantan, S., Subrahmanyam, R, Martindale J.L., Yang, X., Ahmed, F., Navarro, F., Dykxhoorn, D, Lieberman, J, and Gorospe, M. p16INK4a Translation Suppressed by miR-24. PLoS ONE 3:e1864, 2008.

  105. Ishmael, F. T., Fang, X., Prabhu, V. V., Blackshear, P. J., Gorospe, M., Cheadle, C., and Stellato, C. Role of the RNA-binding Protein Tristetraprolin in Glucocorticoid-mediated Gene Regulation. J. Immunol. 180: 8342-53, 2008.[Abs]

  106. Hucl, T., Rago, C., Gallmeier, E., Brody, J., Gorospe, M., and Kern, S.  A syngeneic variance library for functional annotation of human variation: application to BRCA2.  Cancer Research 68: 5023-30, 2008.[Abs]

  107. Kim, H.H., Abdelmohsen, K., Lal, A., Pullmann, R. Jr., Yang, X., Galban, S., Srikantan, S., Martindale, J.L., Blethrow, J., Shokat, K.M.. and Gorospe, M.  Nuclear Retention of HuR Through Phosphorylation by Cdk1. Genes & Development 22:1804-15, 2008.

  108. Kuwano, Y., Kim, H.H., Abdelmohsen, K., Pullmann, R. Jr., Martindale, J.L., Yang, X., and Gorospe, M. MKP-1 mRNA Stabilization and Translational Control by RNA-Binding Proteins HuR and NF90.  Mol. Cell Biol 28:4562-75, 2008.[Abs]

  109. van der Brug, M.P., Blackinton, J., Chandran, J., Hao, L.Y., Lal,  A., Mazan-Mamczarz, K., Martindale, J.L., Xie, C., Ahmad, R., Thomas, K.J., Beilina, A., Gibbs, J.R., Ding, J., Myers, A.J., Zhan, M., Cai, H., Bonini, N.M., Gorospe, M., and M.R. Cookson. RNA binding activity of the recessive parkinsonism protein DJ-1 supports involvement in multiple cellular pathways. Proc. Natl. Acad. Sci. USA 105:10244-9, 2008.[Abs]

  110. Kim, H.H and Gorospe, M.GU-Rich RNA: Expanding CUGBP1 Function, Broadening mRNA Turnover.  Mol. Cell 29:151-2, 2008.[Abs]

  111. Chen, J., Xiao, L., Rao, J. N., Zou, T., Liu, L., Bellavance, E., Gorospe, M., and J.-Y. Wang;  JunD Represses Transcription and Translation of the Tight Junction Protein ZO-1 Modulating Intestinal Epithelial Barrier Function.  Mol. Biol. Cell 19:3701-12, 2008.[Abs]

  112. Mazan-Mamczarz, K., Hagner, P.R.,  Corl, S., Wood W.H., Becker, K.G., Gorospe, M., Keene, J.D., A, Levenson, A.S., and Gartenhaus, R.B.:  Post-transcriptional gene regulation by HuR promotes a more tumorigenic phenotype.  Oncogene 27:6151-63, 2008.[Abs]

  113. Kuwano, Y., and Gorospe, M.  Protecting the stress response, guarding the MKP-1 mRNA.  Cell Cycle 7:2640-2, 2008.[Abs]

  114. Kim, H.H., Gorospe, M.  Phosphorylated HuR Shuttles in Cycles.  Cell Cycle 7:3124-6, 2008.[Abs]

  115. Kim, H.H., Yang, X., Kuwano, Y., and Gorospe, M.  Modification at HuR(S242) Alters HuR Localization and Proliferative Influence.  Cell Cycle 7:3371-7, 2008.[Abs]

  116. Abdelmohsen, K., Srikantan, S., Kuwano, Y., and Gorospe, M.  miR-519 Reduces Cell Proliferation by Lowering RNA-Binding Protein HuR Levels. Proc. Natl. Acad. Sci. USA 105:20297-302, 2008.[Abs]

  117. Mazan-Mamczarz, M., Kuwano, Y., Zhan, M., White, E.J., Martindale, J.L., Lal, A., and Gorospe, M. Identification of a Signature Motif in Target mRNAs of RNA-Binding Protein AUF1.  Nuc. Acids Res. 37:204-14, 2009.[Abs]

  118. Brennan, S.E., Kuwano, Y., Alkharouf, N., Blackshear, P.J., Gorospe, M., and Wilson, G.M. The mRNA-destabilizing protein tristetraprolin is suppressed in many cancers, altering tumorigenic phenotypes and patient prognosis.  Cancer Res. 69:5168-76, 2009.[Abs]

  119. López de Silanes, I., Gorospe, M., Taniguchi, H., Abdelmohsen, K., Srikantan S., Alaminos, M., Berdasco, M., Urdinguio, R.J., Fraga, M.F., Jacinto, F.V., and Esteller, M. The RNA-binding protein HuR regulates DNA Methylation through stabilization of DNMT3b mRNA.  Nuc. Acids Res. 37:2658-71, 2009.[Abs]

  120. Andersen, J.B., Mazan-Mamczarz, K.,  Zhan, M.,  Gorospe, M., Hassel, B.A. Ribosomal protein mRNAs are primary targets of regulation in RNase-L-induced senescence.  RNA Biology (2009, In press).[Abs]

  121. Abdelmohsen, K., Srikantan, S., Yang, X., Lal, A., Kim, H.H., Kuwano, Y., Galban, S., Becker, K. G., Kamara, D., de Cabo, R., and Gorospe, M.  Ubiquitin-mediated proteolysis of HuR by heat shock.  EMBO J. 28:1271-82, 2009.[Abs]

  122. Kuwano, Y., Rabinovic, A., Srikantan, S., Gorospe, M.* (*Co-senior author), and Demple, B.  Analysis of nitric oxide-stabilized mRNAs in human fibroblasts reveals HuR-dependent heme oxygenase-1 upregulation.  Mol. Cell. Biol. 29:2622-35, 2009.[Abs]

  123. Costantino C.L., Witkiewicz, A.K., Kuwano, Y., Cozzitorto, J.,Kennedy, E.P., Dasgupta, A., Keen, J.C., Yeo, C.J., Gorospe, M., and Brody, J.R. HuR’s role in gemcitabine efficacy in pancreatic cancer: HuR upregulates the expression of the gemcitabine metabolizing enzyme, deoxycytidine kinase. Cancer Res. 69:4567-72, 2009.

  124. Masuda, K., Abdelmohsen, K., and Gorospe, M. RNA-binding proteins implicated in the hypoxic response. Journal of Cellular and Molecular Medicine (2009).[Abs]

  125. Figueroa, A., Kotani, H., Toda, Y., Mazan-Mamczarz, K., Mueller, E.C., Otto, A., Disch, L., Norman, M., Ramdasi, R., Keshtgar, M. Gorospe, M., and Fujita, Y.  Novel roles of Hakai in cell proliferation and oncogenesis. Molecular Biology of the Cell. 20(15):3533-42, 2009.[Abs]

  126. Kim, H.H., Kuwano, Y., Srikantan, S., Lee, E.K., Martindale, J.L., and Gorospe, M. HuR recruits let-7/RISC to repress c-Myc expression. Genes & Development. 23(15):1743-8, 2009.[Abs]

  127. Gorospe, M. Ribonucleoprotein dynamics connects mRNA networks with drug mechanisms. Molecular Systems Biology.5:289., 2009).[Abs]

  128. Ale-Agha, N., Galban, S., Sobieroy, C., Abdelmohsen, K., Gorospe, M., Sies, H., Klotz, L.-O. HuR regulates gap junctional intercellular communication by controlling β-catenin levels and adherens junction integrity.  Hepatology2009 Jul 2. [Epub ahead of print].[Abs]

  129. Masuda, K., Marasa, B., Martindale, J.L., Halushka, M.K., and Gorospe, M.  Tissue- and age-dependent expression of RNA-binding proteins that influence mRNA turnover and translation. Aging (In Press, 2009).
Invited Reviews and Book Chapters:
  1. Guyton, K.Z., M. Gorospe and N.J. Holbrook. (1996) Oxidative stress, gene expression and the aging process. In: Oxidative Stress and the Molecular Biology of Antioxidant Defenses, Scandolios, J. (Ed.). Cold Spring Harbor Laboratory Press. pp. 247-272.

  2. Liu, Y, M. Gorospe, N.J. Holbrook and C.W. Anderson. (1996) Post-translational mechanisms leading to mammalian gene activation in response to genotoxic stress. (In press)

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Updated: Monday August 24, 2009