Laboratory of Epidemiology and Population Science

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Michele K. Evans, M.D., Investigator
NIA Deputy Scientific Director,
Chief, Health Disparities Research Section, Laboratory of Epidemiology and Population Sciences

Michele K. Evans, M.D.

Dr. Michele K. Evans, an internist and medical oncologist who currently serves as the Deputy Scientific Director of the Institute and the Training Director for the intramural Research Program. She received her medical degree from Rutgers, The State University of New Jersey, The Robert Wood Johnson Medical School in Piscataway. She received her postgraduate training in internal medicine at the Emory University School of Medicine and fellowship training in medical oncology within the Medicine Branch of the Clinical Oncology Program at the National Cancer Institute (NCI). Interest in human cancer prone disorders and DNA repair led her to study the role of DNA repair in cancer susceptibility as a Senior Clinical Investigator in the Laboratory of Molecular Pharmacology, NCI. At the National Institute on Aging (NIA), her major research interest centers on the clinical implications of eukaryotic DNA repair in aging and health disparities.

Research Interests: The overall goal of my research program has been to conduct translational research defined as a multidisciplinary effort that creates a bi-directional bridge between population- based clinical research and basic science laboratory studies. The central hypotheses focus on understanding which behavioral, psychosocial, and/or molecular and biological mechanisms may be driving factors in the development of health disparities and examining the role of oxidative DNA damage, oxidative stress and oxidative DNA repair in the development of age-related disease. In keeping with this perspective, she has simultaneously developed the Health Disparities Research Section (HDRS) and the DNA Repair Unit (DRU) within the National Institute on Aging’s intramural research program. These two components serve as the research infrastructure for the clinical and basic science projects whose nexus facilitates translation which she believes occurs when both clinical and basic science components are interdependent and pursuing related hypotheses. This two pronged effort is necessary because of the complexity of the clinical problem of health disparities and the scarcity of studies that investigate potential etiological molecular pathways.
The hypotheses pursued in my work to this point include: Project 1- Race and socioeconomic status (SES) influence health status and age-related health disparities separately or synergistically as co-factors of biological, behavioral, psychosocial, and environmental conditions; Project 2- Health disparities promote the development of an Accelerated Aging Phenotype in vulnerable population cohorts characterized by accumulation of oxidative stress and damage to DNA and other cellular components, possible defects in repair of oxidative DNA damage, the augmentation of inflammatory processes, and environmentally induced epigenetic modifications that ultimately result in the disparities noted in national statistics of overall longevity and other health outcomes.

Contact Information:
Laboratory of Epideimiology and Population Science
Biomedical Research Center, room 04C222
251 Bayview Boulevard, Suite 100
Baltimore, MD 21224-6825

Phone 410-558-8573
Fax 410-558-8268
E mail me42v@nih.gov

For more information about the Laboratories:

Health Disparities Research Section:
http://www.irp.nia.nih.gov/branches/leps/hdrs.htm

DNA Repair Unit:
http://www.irp.nia.nih.gov/branches/leps/dnarepair.htm

Laboratory of Epidemiology and Population Science:
http://www.irp.nia.nih.gov/branches/leps/index.htm

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Updated: Friday December 27, 2013